A5100669987- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- Cancer therapeutics and mechanisms
- Heat shock proteins research
- Legionella and Acanthamoeba research
- Antibiotic Resistance in Bacteria
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Bacterial Genetics and Biotechnology
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Genomics and Rare Diseases
- Genomics and Phylogenetic Studies
- Gut microbiota and health
- Mycotoxins in Agriculture and Food
- Enzyme Structure and Function
- Phenothiazines and Benzothiazines Synthesis and Activities
- Pharmaceutical and Antibiotic Environmental Impacts
- Adenosine and Purinergic Signaling
- Lipoproteins and Cardiovascular Health
- Retinoids in leukemia and cellular processes
- Angiogenesis and VEGF in Cancer
- Pediatric health and respiratory diseases
- Insect and Pesticide Research
- Chromosomal and Genetic Variations
Chinese Academy of Medical Sciences & Peking Union Medical College
2011-2025
Peking Union Medical College Hospital
2025
Xiamen University
2025
Second Affiliated Hospital of Fujian Medical University
2015-2024
Fujian Medical University
2015-2024
China West Normal University
2024
Ludong University
2024
Tianjin Children's Hospital
2022-2024
Tianjin University
2022-2024
Harbin Institute of Technology
2024
Healthcare insurance fraud imposes a significant financial burden on healthcare systems worldwide, with annual losses reaching billions of dollars. This study aims to improve detection accuracy using machine learning techniques. Our approach consists three key stages: data preprocessing, model training and integration, result analysis feature interpretation. Initially, we examined the dataset's characteristics employed embedded permutation methods test performance runtime single models under...
To ensure survival of engineered implantable tissues thicker than approximately 2-3 mm, convection nutrients and waste products to enhance the rate transport will be required. Creating a network vessels in vitro, before implantation (prevascularization), is one potential strategy achieve this aim. In study, we developed three-dimensional vessel networks vitro by coculture endothelial cells (ECs) fibroblasts fibrin gel for 7 days. Vessels formed cord blood progenitor cell-derived ECs...
// Xiaolan Zhu 1, 2, * , Huiling Shen 3, Xinming Yin 1 Lulu Long 3 Xiaofang Chen Fan Feng Yueqin Liu Peiqing Zhao 2 Yue Xu Mei Li 4 Wenlin and Yuefeng Department of Gynecologic Oncology, The Fourth Affiliated Hospital Jiangsu University, Zhenjiang, 212001, China Medical School, 212003, People Radiology, These authors are considered as co-first Correspondence to: Xu, email: xwl630806@126.com Li, lxz1986122@sina.com Keywords: miR-204, IL-6R, STAT3, chemoresistance, EOC Received: January 23,...
Previous studies indicate that miR-149 could both inhibit and promote the development of human cancer depending on tumor type. GIT1 was found to play an important role in regulating cell migration. However, specific function miR-149-5p progression medullary thyroid carcinoma (MTC) remains unknown. The purpose this study confirm MTC explore its downstream regulation. Moreover, level detected via RT-quantitative PCR (RT-qPCR). expression levels were assessed by RT-qPCR western blot analysis....
ATR is one of the key DNA damage response (DDR) regulatory factors to maintain genome stability. inhibition induces accumulation and apoptosis in DDR kinase mutation or deficiency cancer cells through synthetic lethality, making it a promising target for treatment cancers with defects. Herein, we describe discovery preclinical evaluation YY2201, highly potent selective novel inhibitor, favorable ADME, safety pharmacology, pharmacokinetics profiles. YY2201 efficiently inhibits tumor...
The aim of the present study was to investigate association between cell-free DNA (cf-DNA) levels and clinicopathological characteristics patients with ovarian cancer using a branched (bDNA) technique, determine value quantitative cf-DNA detection in assisting diagnosis cancer. Serum specimens were collected from 36 on days 1, 3 7 following surgery, additional serum samples also 22 benign tumor cases, 19 healthy, non-cancerous ovaries. bDNA techniques used detect concentrations. All data...
It is well established that angiogenesis a complex and coordinated multistep process. However, there remains lack of information about the genes regulate individual stages vessel formation. Here, we aimed to define role human interferon-induced transmembrane protein 1 (IFITM1) during blood formation.We identified IFITM1 in microarray screen for differentially regulated by endothelial cells (ECs) an vitro assay found expression was strongly induced as ECs sprouted formed lumens. We showed...
Intracellular survival of pathogenic bacteria leads to high chances bacterial persistence and relapse in the bacteria-infected host. However, many antibiotics fail clear intracellular due their low internalization by cells. In order increase delivery cells eliminate bacteria, we developed antibiotic-derived lipid nanoparticles. First, synthesized conjugates using two widely used including penicillin G (PenG) levofloxacin (Levo). Then, formulated them into nanoparticles evaluated...
Inflammatory bowel disease (IBD), which includes ulcerative colitis (UC) and Crohn's (CD), is a chronic, progressive, recurrent intestinal condition that poses significant global health burden. The high prevalence of neuropsychiatric comorbidities in IBD necessitates the development targeted management strategies.Leveraging genetic data from genome-wide association studies Immunochip genotype analyses nearly 150,000 individuals, we conducted two-sample Mendelian randomization study to...
Studies have confirmed that microRNAs play important roles in the development and progression of cancer. Therefore, to identify differentially expressed between cancer normal tissues, will provide new clues for exploring molecular mechanisms potential targeted therapies. In present study, we found miR-338-3p was downregulated hypopharyngeal carcinoma inversely correlated with pathological grade. When further downregulated, migration invasion ability FaDu cells were enhanced, these functions...
Although previous studies have reported the gut microbiome is closely related to hypertension development, whether change in blood associated with risk of remains unclear.One hundred and fifty incident cases 150 age (± 2 years) gender (1:1) matched nonhypertension controls included this nested case-control study were recruited from a prospective cohort "135." The composition was characterized using bacterial 16S ribosomal RNA gene sequencing. relative abundance detected bacteria converted...
Phosphoserine aminotransferase deficiency (PSATD) is an autosomal recessive disorder associated with hypertonia, psychomotor retardation, and acquired microcephaly. Patients PSATD have low concentrations of serine in plasma cerebrospinal fluid.
The molecular mechanisms underlying premature ovarian failure, which seriously impacts the physical and psychological health of patients, are not fully understood. Here, we present role TRDMT1 in reactive oxygen species-induced granulosa cells death, is considered an important cause failure. We found that species were increased a H2O2 dose-dependent manner accompanied by nuclear shuttling TRDMT1, DNA damage apoptosis cells. In addition, could be prevented antioxidant N-acetylcysteine or...