The secretory properties of cancer-associated fibroblasts (CAFs) play predominant roles in shaping a pro-metastatic tumor microenvironment. present study demonstrated that SLIT2, an axon guidance protein, produced by CAFs and promoted gastric cancer (GC) metastasis two cell lines (AGS MKN45) binding to roundabout receptor 1 (ROBO1). Mass-spectrometry analysis revealed ROBO1 could interact with NEK9, serine/threonine kinase. And their mutual activities were further enhanced SLIT2. Domain the...

China is the first country to use heterosis successfully for commercial rice production. This study compared main quality characteristics (head rate, chalky chalkiness degree, gel consistency, amylose content, and length-to-width ratio) of 635 varieties (not including upland glutinous rice) released from 2000 2014 establish status offer suggestions future breeding grain in China. In past 15 years, japonica indica hybrid has improved. rice, inbred have increased head rates decreased degree...

Abstract Maize is one of China's most important grain crops. We analysed data from breeding trials and experimental reports to assess genetic gains in the single‐cross varieties terms yield agronomic traits Northern China, Southwestern China Yellow–Huai River Valley. Since 1960s, has increased linearly all three regions. Plant height, ear rows 100‐seed weight have (P < 0.05) with time, while length decreased 0.05). Planting density Valley but no change China. Ear height leaf number over...

// Xiaolan Zhu 1, 2, * , Huiling Shen 3, Xinming Yin 1 Lulu Long 3 Xiaofang Chen Fan Feng Yueqin Liu Peiqing Zhao 2 Yue Xu Mei Li 4 Wenlin and Yuefeng Department of Gynecologic Oncology, The Fourth Affiliated Hospital Jiangsu University, Zhenjiang, 212001, China Medical School, 212003, People Radiology, These authors are considered as co-first Correspondence to: Xu, email: xwl630806@126.com Li, lxz1986122@sina.com Keywords: miR-204, IL-6R, STAT3, chemoresistance, EOC Received: January 23,...

Genetic improvements have significantly contributed to wheat production. Five cultivars—widely grown in north China the 1950s, 1990s or 2010s—were field experiments conducted 2014–2015 and 2015–2016 growing seasons. This study evaluated genetic progress grain yield its related traits explored how breeding selection influenced numbers weights within spikelets past 60 years. The results showed that significant increases years were mainly due number per spike weight, while m2 has not changed...

The Na+/H+ exchanger (NHE1) plays a crucial role in cancer cell proliferation and metastasis. However, the mechanism underlying chemotherapeutic resistance cells has not been completely elucidated. NHE1 inhibitor cariporide demonstrated to inhibit human lines. goal of this study was provide new sights into improved chemosensitivity mediated by with activation apoptosis pathway.The expression levels were first evaluated using online database Oncomine determined RT-PCR western blot vitro vivo....

Previous studies have shown that TIPE1 inhibits tumor proliferation and metastasis in certain cancers; however, increased expression of is observed cervical cancer cell lines tissues, indicating it might exert a distinctive role cancer. Cell xenograft tumorigenicity assays showed facilitates progression this study. Further investigation demonstrated binds to p53 impairs its activity via inhibition acetylation. In addition, promoted suppressed cisplatin susceptibility p53-dependent manner,...

Abstract Aims Experimental evidence demonstrated a crucial role of TROAP (Trophinin‐associated protein) in regulating the cell proliferation multiple tumors, while expression and function were largely unknown glioma. We aimed to investigate oncogenic its potential mechanisms gliomagenesis. Methods Four gene databases (GEO, TCGA, GTEx CCLE) enrolled our study used for survival analysis. was quantified by qRT‐PCR, western blot immunohistochemistry assays glioma tissues lines. knockdown...

Breeding and cultivar improvement are important for increasing crop yields. In this study, 1472 soybean cultivars released in the last 60 years 683 landrace from three regions of China (North spring region, Yellow-Huai-Hai summer South region) were collated to examine changes agronomic characters plant density that might be associated with yield improvement. The 100-seed weight increased significantly over time all regions. Planting decreased but did not change North region. yields mainly...

Liver X receptor (LXR) agonists inhibit various types of tumor growth and have been applied to preclinical research. In colon cancer cells, LXR induce pyroptotic cell death through the predominant cytoplasmic localisation LXRβ. present study, we determined whether induced by in cells could elicit immunogenic (ICD). agonist‐treated‐colon exhibited translocation calreticulin (CRT) release HMGB1 ATP into medium. Expression levels CRT were also increased T0901317‐treated Balb/c mice....

Gliomas are a group of primary intracranial tumors with high morbidity and mortality. The previous researches indicated crucial role CKS2 (cyclin-dependent kinases regulatory subunit 2) in hepatocellular carcinoma breast cancer; however, little is known about the molecular mechanism tumorigenesis epithelial-mesenchymal transition-like (EMT) process glioma.Datasets for bioinformatics analysis were obtained from GEO, TCGA CGGA databases. qRT-PCR, western blotting (WB), immunohistochemistry...

Abstract Liver X receptors ( LXR s) are involved in various diseases associated with lipid disorders, and regulating cancer cell proliferation. However, the underlying molecular mechanisms, especially those gastric GC ) remain to be clarified. In this study, immunohistochemistry analysis revealed that β was mainly expressed tissue, less expression adjacent normal tissues. The agonist T0901317 efficiently suppressed proliferation colony formation of lines. We further showed translocated from...

Abstract PNO1 (partner of Nob1) was known as a RNA‐binding protein in humans, and its ortholog reported to participate ribosome proteasome biogenesis yeasts. Yet there have been few studies about functions mammalian cells, so far role human cells has never reported, especially urinary bladder cancer (UBC).We interrogated the cellular clinical significance in, molecular mechanism through microarrays bioinformatics analysis. Our findings support that participates promoting proliferation...

Prostate cancer (PC) is a common neoplasm, and metastatic PC remains incurable. The study aims to screen key microRNAs (miRNAs) transcription factors (TFs) involved in PC. miRNA expression profile dataset (GSE45604) was downloaded from Gene Expression Omnibus database, including 50 10 normal specimens. Differentially expressed miRNAs (DEmiRNAs) were identified through limma package R, DEmiRNA–DEmiRNA co-regulation network constructed based on the number of co-regulated target genes....

Abstract Background Temperature control plays a pivotal role in patients with heat stroke (HS), but little work has been done sufficiently on the use of temperature to reflect disease progression. Here, we defined and analyzed concrete controlling time for core physiological level (CTTP), order explore potential index guide treatment HS. Method This is retrospective cohort study. From three hospitals located Sichuan province, China, collected total 179 HS cases clinical diagnosis records. We...

Long-term heat stress (HS) severely restricts the growth performance of beef cattle and causes various health problems. The gut microbiota plays a crucial role in HS-associated inflammation immune involving lymphocyte function. This study investigated effects dietary tea polysaccharide (TPS), natural acidic glycoprotein, on HS-induced anorexia, inflammation, dysbiosis Simmental cattle.

Prostate stem cell antigen (PSCA) is upregulated in prostate cancer tissues. Here we aimed to study the therapeutic efficacy of a monoclonal antibody PSCA-labeled I131 (I131-PSCA-mAb) orthotopic mouse models cancer.The proliferation, apoptosis and invasion abilities PC-3 LNCaP cells treated with I131-PSCA-mAb were measured by methyl thiazolyl tetrazolium assay, flow cytometry transwell culture, respectively. The human established implantation nude mice. distribution tumor tumor-bearing mice...