A5032523201- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Hypoxia, and Metabolism
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- RNA modifications and cancer
- Virus-based gene therapy research
- Galectins and Cancer Biology
- Cancer-related molecular mechanisms research
- Protein Degradation and Inhibitors
- NF-κB Signaling Pathways
- Macrophage Migration Inhibitory Factor
- Bone Metabolism and Diseases
- Hepatitis B Virus Studies
- Advanced biosensing and bioanalysis techniques
- Neurological Disease Mechanisms and Treatments
- Immune Cell Function and Interaction
- RNA Research and Splicing
- Parkinson's Disease Mechanisms and Treatments
- Barrier Structure and Function Studies
- Phagocytosis and Immune Regulation
- Connective tissue disorders research
- Gas Sensing Nanomaterials and Sensors
Central Hospital of Zibo
2016-2025
Binzhou Medical University
2022-2025
Shandong University
2015-2024
Xinjiang Medical University
2024
Queen's University
2024
Shandong First Medical University
2024
Second Affiliated Hospital of Xinjiang Medical University
2024
Xinxiang Medical University
2024
Brown University
2024
Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
2021
Abstract Circular RNA FOXO3 ( CircFOXO3 , also termed as Hsa_circ_0006404 ) is derived from exon 2 of forkhead box O3 gene, and abnormal expression shown in different diseases. However, whether circFOXO3 plays important roles tumorigenesis progression prostate cancer (PCa) remains unclear. In this study, we found that was up‐regulated both PCa tissues serum samples. Moreover, positively correlated with the Gleason score observed to be > 6 samples compared = Knock‐down could remarkably...
// Xiaolan Zhu 1, 2, * , Huiling Shen 3, Xinming Yin 1 Lulu Long 3 Xiaofang Chen Fan Feng Yueqin Liu Peiqing Zhao 2 Yue Xu Mei Li 4 Wenlin and Yuefeng Department of Gynecologic Oncology, The Fourth Affiliated Hospital Jiangsu University, Zhenjiang, 212001, China Medical School, 212003, People Radiology, These authors are considered as co-first Correspondence to: Xu, email: xwl630806@126.com Li, lxz1986122@sina.com Keywords: miR-204, IL-6R, STAT3, chemoresistance, EOC Received: January 23,...
Abstract The ketogenic diet (KD) is a low‐carbohydrate, high‐fat regime that protective against neurodegenerative diseases. However, the impact of KD on Parkinson's disease (PD) and its mechanisms remains unclear. 1‐Methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP)‐induced mouse model PD was fed with for 8 weeks. Motor function dopaminergic neurons were evaluated. Inflammation in brain, plasma, colon tissue also measured. Fecal samples assessed by 16S rDNA gene sequencing untargeted...
Long non-coding RNAs (lncRNAs) are non-protein-coding transcripts that play important roles in tumorigenesis and tumor progression. Our study aimed to explore the role of lncRNA MAGI2-AS3 breast cancer metastatic In present study, our results showed can inhibit migration invasion cells. addition, an increase microRNA-374a (miR-374a) expression Bioinformatic analysis predicted correlation between miR-374a. Phosphatase tensin homolog (PTEN) was found be novel mRNA target upregulation inhibited...
// Xuechao Wan 1, * , Honglei Pu Wenhua Huang 1 Shu Yang Yalong Zhang Zhe Kong Zhuoran Peiqing Zhao 3 Ao Li Tao Yao 2 State Key Laboratory of Genetic Engineering, Shanghai Engineering Research Center Industrial Microorganisms, School Life Science, Fudan University, Shanghai, 200433, PR China Reproduction Regulation NPFPC, Translational Medicine, Central Hospital Zibo, Shangdong, 255036, These authors contributed equally to this work Correspondence to: Li, email: yaoli@fudan.edu.cn...
Osteosarcoma (OS), the most common primary malignancy of bone, has a poor prognosis due to its high mortality rate and potential for metastasis. Thus, it is urgently necessary explore functional molecular targets therapeutic strategies osteosarcoma. Here, we reported that TIPE1 expression was decreased in osteosarcoma tissues compared normal adjacent nontumor tissues, negatively related tumor stage size. Functional assays showed inhibited carcinogenesis metastatic both vivo vitro....
Currently, the construction of heterojunctions as a method to enhance photoelectrochemical (PEC) activity has shown prospective applications in analytical field. Restricted by carrier separation at interface, developing heterojunction sensing platform with high sensitivity remains challenging. Here, double-photoelectrode PEC was fabricated based on an antenna-like strategy integrating MIL-68(In)–NH2, p-type metal–organic framework (MOF) photocatalyst, photocathode type-II CdSe/MgIn2S4...
Osteosarcoma (OS) chemoresistance presents a significant clinical challenge. This study aims to investigate the potential of using tumor vascular-targeting peptide NGR-modified cancer-associated fibroblasts (CAFs)-derived exosomes (exos) deliver circ_0004872-encoded small peptides promoting autophagy-dependent ferroptosis reverse in OS. Through combined single-cell transcriptome analysis and high-throughput sequencing, it identified circ_0004872 associated with chemoresistance. Subsequent...
Diabetes-associated cognitive dysfunction (DACD) is increasingly recognized as a critical complication of diabetes. The complex pathology DACD remains unknown. Here, we performed single-nucleus RNA sequencing (snRNA-seq) to demonstrate unique cellular and molecular patterns the hippocampus from mouse model More in-depth analysis oligodendrocytes (OLs) distinguished five subclusters, indicating different functional states OLs transcriptional changes in each subcluster. Based on results...
Previous studies have shown that TIPE1 inhibits tumor proliferation and metastasis in certain cancers; however, increased expression of is observed cervical cancer cell lines tissues, indicating it might exert a distinctive role cancer. Cell xenograft tumorigenicity assays showed facilitates progression this study. Further investigation demonstrated binds to p53 impairs its activity via inhibition acetylation. In addition, promoted suppressed cisplatin susceptibility p53-dependent manner,...
Objectives Although there is evidence that visfatin associated with atherogenesis, the effect of on plaque stability has not yet been explored. Methods In vivo, vulnerable plaques were established by carotid collar placement in apolipoprotein E–deficient (ApoE−/−) mice, and lentivirus expressing (lenti-visfatin) was locally infused artery. The lipid, macrophage, smooth muscle cell (SMC) collagen levels evaluated, vulnerability index calculated. vitro, RAW264.7 cells stimulated visfatin, MMPs...
Recent studies have shown that tumour necrosis factor-α-induced protein 8 like-1(TIPE1) plays distinct roles in different cancers. TIPE1 inhibits proliferation and metastasis a variety of tumours but acts as an oncogene cervical cancer. The role nasopharyngeal carcinoma (NPC) remains unknown. Interestingly, expression was remarkably increased NPC tissue samples compared to adjacent normal epithelial our study. positively correlated with the marker Ki67 negatively patient lifespan. In vitro,...