A5078890396- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Prostate Cancer Treatment and Research
- Circular RNAs in diseases
- MicroRNA in disease regulation
- Cancer, Lipids, and Metabolism
- Cancer Genomics and Diagnostics
- Genomics and Chromatin Dynamics
- Aquaculture Nutrition and Growth
- Pluripotent Stem Cells Research
- Infectious Diseases and Tuberculosis
- Reproductive biology and impacts on aquatic species
- Estrogen and related hormone effects
- Renal and related cancers
- Fish Ecology and Management Studies
- Nuts composition and effects
- Tuberculosis Research and Epidemiology
- Prostate Cancer Diagnosis and Treatment
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Mycobacterium research and diagnosis
Eastern Hepatobiliary Surgery Hospital
2024
Second Military Medical University
2024
State Key Laboratory of Genetic Engineering
2015-2022
Fudan University
2015-2022
Sun Yat-sen University
2020
Background Prostate cancer (PCa) is a leading cause of death in males all over the world; besides, diagnosis and therapy it are still challenging. Researchers have revealed that long non‐coding RNAs (lncRNAs) play important roles genesis progression human cancers, including PCa. Methods Bioinformatics analysis Kaplan‐Meier survival were utilized to confirm TMPO‐AS1 as diagnostic prognostic marker. The levels both patient tissues PCa cell lines determined by qRT‐PCR analysis. Moreover,...
// Xuechao Wan 1, * , Honglei Pu Wenhua Huang 1 Shu Yang Yalong Zhang Zhe Kong Zhuoran Peiqing Zhao 3 Ao Li Tao Yao 2 State Key Laboratory of Genetic Engineering, Shanghai Engineering Research Center Industrial Microorganisms, School Life Science, Fudan University, Shanghai, 200433, PR China Reproduction Regulation NPFPC, Translational Medicine, Central Hospital Zibo, Shangdong, 255036, These authors contributed equally to this work Correspondence to: Li, email: yaoli@fudan.edu.cn...
Androgen receptor (AR) is a ligand dependent transcription factor that regulates the of target genes. AR activity closely involved in maintenance and progression prostate cancer. After binding with androgen, moves into nucleus binds to DNA sequence containing androgen response elements (ARE). Flavin-dependent monoamine oxidase KDM1A necessary for driven while mechanism remains unclear.The association between androgen-dependent oxidation was tested through pharmaceutical inhibitions siRNA...
Biochemical recurrence (BCR) is widely used to define the treatment success and make decisions on if or how initiate a secondary therapy, but uniform criteria BCR after radical prostatectomy (RP) not yet completely assessed. UHRF1 has unique function in regulating epigenome by linking DNA methylation with histone marks. The clinical value of PCa been well done. Therefore, we evaluated prognostic significance UHRF1. expression cells was monitored qRT-PCR Western blot analyses. knocked down...
Long noncoding RNAs (lncRNAs) have been found as novel participants in the pathophysiology of prostate cancer (PCa), which is predominantly regulated by androgen and its receptor. The biological function androgen-responsive lncRNAs remains poorly understood. Here, we identified that lncRNA RP11-1023L17.1, highly expressed PCa. RP11-1023L17.1 expression, can be directly repressed receptor PCa cells. depletion inhibited proliferation, migration, cell cycle progression, promoted apoptosis...
Abstract Background Androgen receptor (AR) is crucial for prostate cancer (PCa) initiation and malignant progression. Only half of androgen‐responsive genes have been identified as having elements, suggesting that AR regulates downstream through other transcriptional factors. However, whether how the progression via regulating these remains unclear. Methods Androgen‐responsive activity‐changed (AC) factors (TFs) were based on time‐course gene‐expression array gene promoter regions analysis....
Prostate cancer (PCa) was one of the most common cancers in males China. Long non-coding RNAs (lncRNA), a class with more than 200 nucleotides, played key roles progression prostate cancer. GLIDR, novel long intergenic ncRNA, found to be upregulated tumors c ompared normal tissues by using publically databases. In clinical validation cohort, our results showed GLIDR significantly up-regulated samples and cell lines. To explore potential functions we constructed gene co-expression networks...