A5031354959- Tryptophan and brain disorders
- Inflammasome and immune disorders
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Enzyme Structure and Function
- Amyotrophic Lateral Sclerosis Research
- RNA and protein synthesis mechanisms
- Biochemical and Molecular Research
- HIV/AIDS drug development and treatment
- Microbial Metabolic Engineering and Bioproduction
- Cholinesterase and Neurodegenerative Diseases
- Stress Responses and Cortisol
- Protein Structure and Dynamics
- Macrophage Migration Inhibitory Factor
- Antifungal resistance and susceptibility
- Diabetes and associated disorders
- Metabolomics and Mass Spectrometry Studies
- Neural and Behavioral Psychology Studies
- Cholesterol and Lipid Metabolism
- Medication Adherence and Compliance
- Periodontal Regeneration and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Diet and metabolism studies
- Neurogenetic and Muscular Disorders Research
- Hearing, Cochlea, Tinnitus, Genetics
Icahn School of Medicine at Mount Sinai
2019-2023
Universidad de Zaragoza
2015-2019
Rajiv Gandhi Centre for Biotechnology
2014-2019
Universidad Complutense de Madrid
2017
Hospital Universitario 12 De Octubre
2014
Abstract Sleep deprivation is a form of stress that provokes both inflammatory responses and neuropsychiatric disorders. Because persistent inflammation implicated as physiological process in anxiety disorders, we investigated the contributions NLRP3 inflammasome signaling to anxiolytic properties flavanol diets model chronic sleep deprivation. The results show flavanol-rich dietary preparation (FDP) exhibits by attenuating markers neuroimmune activation, which included IL-1β upregulation,...
Inflammasomes are macromolecular complexes involved in the host response to external and endogenous danger signals. Inflammasome-mediated sterile inflammation plays a central role several human conditions such as autoimmune diseases, type-2 diabetes, neurodegenerative disorders, indicating inflammasomes could be appealing therapeutic targets. Previous work has demonstrated that inhibiting ATPase activity of nucleotide-binding oligomerization domain, leucine-rich repeat pyrin...
Riboflavin kinases (RFKs) catalyse the phosphorylation of riboflavin to produce FMN. In most bacteria this activity is catalysed by C-terminal module a bifunctional enzyme, FAD synthetase (FADS), which also catalyses transformation FMN into through its N-terminal adenylyltransferase (FMNAT) module. The RFK FADS homologue eukaryotic monofunctional RFKs, while FMNAT lacks homologyto enzymes involved in production. Previously, crystal structure Corynebacterium ammoniagenes ( Ca FADS) was...
The increase of bacterial strains resistant to most the available antibiotics shows a need explore novel antibacterial targets discover antimicrobial drugs. Bifunctional FAD synthetases (FADSs) synthesise flavin mononucleotide (FMN) and adenine dinucleotide (FAD). These cofactors act in vital processes as part flavoproteins, making FADS an essential enzyme. Bacterial FADSs are potential because differences mammalian enzymes, particularly at producing site. We have optimised activity-based...
Bifunctional FAD synthetases (FADSs) fold in two independent modules; The C-terminal riboflavin kinase (RFK) catalyzes the RFK activity, while N-terminal FMN-adenylyltransferase (FMNAT) exhibits FMNAT activity. search for macromolecular interfaces Corynebacterium ammoniagenes FADS (CaFADS) crystal structure predicts a dimer of trimers organization. Within each trimer, head-to-tail arrangement causes and catalytic sites neighboring protomers to approach, agreement with active site residues...
Prokaryotic bifunctional FAD synthetases (FADSs) catalyze the biosynthesis of FMN and FAD, whereas in eukaryotes two enzymes are required for same purpose. key cofactors to maintain flavoproteome homeostasis all type organisms. Here we shed light properties hitherto unstudied bacterial FADS from human pathogen Streptococcus pneumoniae (SpnFADS). As other members family, SpnFADS catalyzes three typical activities prokaryotic FADSs: riboflavin kinase (RFK), ATP:FMN:adenylyltransferase (FMNAT),...
Abstract Enzymes known as bifunctional and bimodular prokaryotic type-I FAD synthetase (FADS) exhibit ATP:riboflavin kinase (RFK) FMN:ATP adenylyltransferase (FMNAT) activities in their C-terminal N-terminal modules, respectively, produce flavin mononucleotide (FMN) adenine dinucleotide (FAD). These act cofactors of a plethora flavoproteins all organisms. Therefore, regulation production maintains the cellular flavoproteome homeostasis. Here, we focus on FMN synthesis Corynebacterium...
Overexposure to mental stress throughout life is a significant risk factor for the development of neuropsychiatric disorders, including depression and anxiety. The immune system can initiate physiological response, releasing hormones pro-inflammatory cytokines, in response stressors. These effects overcome allostatic mechanisms generate environment with deleterious if occurring chronically. Previous studies our lab have identified key anti-inflammatory properties bioavailable polyphenolic...
The exact factors that determine the biological behavior of odontogenic lesions have not been thoroughly established yet. influence matrix metalloproteinases (MMPs) on clinical these was recently brought to light.We did a pioneer study investigate association MMP9 (rs3918242 [-1562 C/T] and rs17576) MMP2 (rs243865 [-1306 rs865094) gene polymorphisms aggressiveness ameloblastomas, keratocystic tumors (KCOT) dentigerous cysts (DC).A case-control conducted in Department Oral Pathology...
Emergence of multidrug-resistant bacteria forces us to explore new therapeutic strategies, and proteins involved in key metabolic pathways are promising anti-bacterial targets. Bifunctional flavin-adenine dinucleotide (FAD) synthetases (FADS) prokaryotic enzymes that synthesise the flavin mononucleotide (FMN) FAD cofactors. The FADS from human pathogen Streptococcus pneumoniae (SpnFADS)–causative agent pneumonia humans − shows relevant catalytic dissimilarities compared other FADSs. Here, by...
This cross-sectional study examined whether changes occur in people’s capacity to coordinate two simultaneous tasks (dual-task) when transitioning from adulthood later life. The central executive, Baddeley’s working memory model component, is responsible for this coordination. Contradictory results have been reported regarding the relationship between ageing and dual-task performance; but these seem be related methodological issues that addressed study.Nine hundred seventy-two...
Background Autosomal recessive nonsyndromic sensorineyral hearingloss also known as “DFNB” causes 20% of all childhood deafness and may have carrier rate high 2.8%. Fifty to eighty percent DFNB cases causing severe profound hearing impairment, results from mutations in a single gene, GJB2(DFNB1), that encodes the protein connexin 26(Cx26) located on chromosome 13q11-12. Aim this study was explore status reported pathogenic mutation well novel variants South Indian population.
Abstract Intronic G 4 C 2 hexanucleotide repeat expansions (HRE) of C9orf72 are the most common cause familial variants frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS). HREs in undergo non-canonical repeat-associated translation, producing dipeptide (DPR) proteins, with various deleterious impacts on cellular homeostasis. While five different DPRs produced, poly(glycine-arginine) (GR) is amongst toxic and only DPR to accumulate associated clinically relevant anatomical...
RESUMENEntre las complicaciones de la cirugía discal lumbar, una, poco frecuente pero especialmente incapacitante es ceguera.Presentamos un caso ceguera cortical transitoria tras una microcirugía convencional L5-S1 en paciente sana.Se discuten posibles causas propuestas por literatura, y se propone el embolismo gaseoso como origen probable experimentada paciente.Al tratarse complicación diagnóstico difícil, con cierto grado posibilidad prevención, tratamiento eficaz, analizan también los...
Psychological stress acts as a risk factor for cognitive deterioration and Alzheimer's disease (AD). In addition, formation of associated speck-like protein containing CARD (ASC) specks the subsequent activation innate immune inflammasome complexes, including NLRP3, by sterile inflammatory signals, such high mobility group box-1 (HMGB-1), are critical social stress-induced depressive behavior, promote AD phenotypes. We administered chronic unpredictable (CUS) paradigm to wild-type mice,...