A5044318849- Dermatology and Skin Diseases
- Receptor Mechanisms and Signaling
- Ion channel regulation and function
- Asthma and respiratory diseases
- Neuropeptides and Animal Physiology
- Cardiac electrophysiology and arrhythmias
- Mesenchymal stem cell research
- Mast cells and histamine
- Ion Channels and Receptors
- Chemotherapy-related skin toxicity
- Spinal Cord Injury Research
- IL-33, ST2, and ILC Pathways
- Neuroscience and Neuropharmacology Research
- Exercise and Physiological Responses
- Neurogenesis and neuroplasticity mechanisms
- RNA Interference and Gene Delivery
- Cancer, Stress, Anesthesia, and Immune Response
- Advancements in Transdermal Drug Delivery
- Nerve injury and regeneration
- Sympathectomy and Hyperhidrosis Treatments
- Allergic Rhinitis and Sensitization
- Neurobiology and Insect Physiology Research
- Psoriasis: Treatment and Pathogenesis
- Pharmacological Effects of Natural Compounds
- Pain Mechanisms and Treatments
National Institute of Dental and Craniofacial Research
2018-2022
National Institutes of Health
2021
Johns Hopkins Medicine
2014-2019
Johns Hopkins University
2014-2019
University of California, Davis
2010-2016
National Chung Hsing University
2007
Itch is an unpleasant skin sensation that can be triggered by exposure to many chemicals, including those released mast cells. The natriuretic polypeptide b (Nppb)-expressing class of sensory neurons, when activated, elicits scratching responses in mice, but it unclear which itch-inducing agents stimulate these cells and the receptors involved. Here, we identify expressed Nppb neurons demonstrate functional importance as sensors endogenous pruritogens Our search for reveals they express...
Itch sensory neurons can be sensitized by OSM released from dermal immune cells.
It is well recognized that bone marrow stromal cells (MSCs) can differentiate into neuron-like when supplemented with growth factors and/or chemical treatments. We demonstrated primary MSCs obtained from adult rats could spontaneously neural precursor after long-term culture. During the outset of in vitro culture, less than 0.1% rat expressed nestin, common protein precursors. These didn't show neuronal morphology nor express antigens. In contrast, continuous maintenance for 6 weeks, a...
In this study, we sought to elucidate the molecular mechanism underlying human Mas-related G protein–coupled receptor X1 (MrgprX1)-mediated itch sensation. We found that activation of MrgprX1 by BAM8-22 triggered robust action potential discharges in dorsal root ganglion neurons. This neuronal excitability is not mediated transient (TRP) cation channels, M-type potassium or chloride channels. Instead, lowers threshold tetrodotoxin-resistant sodium channels and induces inward currents. These...
Itch is an unpleasant sensation that often accompanies chronic dermatological conditions. Although many of the itch receptors and neural pathways underlying this are known, identity endogenous ligands still not fully appreciated. Using unbiased bioinformatic approach, we identified GPR15L as a candidate pruritogen whose expression robustly up-regulated in psoriasis atopic dermatitis. was previously shown to be cognate ligand receptor GPR15, expressed dermal T cells, here show it also...
Abstract Previous studies have shown that the activation of mouse MrgC11, a G‐protein‐coupled receptor, by its peptide ligand BAM8‐22 can inhibit chronic pain. A large‐scale screen has been carried out to isolate small‐molecule allosteric agonists MrgX1, human homologue MrgC11. The goal this study is improve efficacy and potency positive modulators (PAMs) with therapeutic implications in combating Herein we report an iterative parallel synthesis effort structure–activity relationship series...
Several reports demonstrated that transplantation of bone marrow stromal cells could ameliorate the functional deficit after spinal cord injury. However, evidence axon regeneration from supraspinal neurons has not been reported yet. Using neuroanatomical tracing technique and immunohistochemical staining methods, we studied whether adult promote Retrograde revealed regenerated axons originated brain stem nuclei, including red nucleus, locus coeruleus, raphe vestibular reticular formation....