A5100356633- Parkinson's Disease Mechanisms and Treatments
- Pain Mechanisms and Treatments
- Ion Channels and Receptors
- Restless Legs Syndrome Research
- Dysphagia Assessment and Management
- Neurobiology and Insect Physiology Research
- Alzheimer's disease research and treatments
- Ferroptosis and cancer prognosis
- RNA modifications and cancer
- Dermatology and Skin Diseases
- Tracheal and airway disorders
- Receptor Mechanisms and Signaling
- Sleep and Wakefulness Research
- Neuropeptides and Animal Physiology
- Botulinum Toxin and Related Neurological Disorders
- Neuroendocrine regulation and behavior
- Biochemical effects in animals
- Transcranial Magnetic Stimulation Studies
- Airway Management and Intubation Techniques
- Memory and Neural Mechanisms
- Stroke Rehabilitation and Recovery
- Health Systems, Economic Evaluations, Quality of Life
- Ginkgo biloba and Cashew Applications
- Obstructive Sleep Apnea Research
- Neonatal and fetal brain pathology
Guangzhou University of Chinese Medicine
2013-2025
The Affiliated Shunde Hospital of Jinan University
2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Shanghai Sunshine Rehabilitation Center
2021
Hainan University
2020
Second Affiliated Hospital of Guangzhou Medical University
2020
Guangzhou Medical University
2017-2020
Johns Hopkins University
2012-2019
Johns Hopkins Medicine
2012-2019
First Affiliated Hospital of Guangzhou Medical University
2017-2019
β-alanine, a popular supplement for muscle building, induces itch and tingling after consumption, but the underlying molecular neural mechanisms are obscure. Here we show that, in mice, β-alanine elicited itch-associated behavior that requires MrgprD, G-protein-coupled receptor expressed by subpopulation of primary sensory neurons. These neurons exclusively innervate skin, respond to heat, mechanical noxious stimuli do not histamine. In humans, intradermally injected induced neither wheal...
This study investigated the neural mechanisms underlying Parkinson's disease (PD) subtypes-tremor dominant (TD) and postural instability gait difficulty (PIGD)-by analyzing regional homogeneity (ReHo) values from resting-state functional MRI. Fifty-nine PD patients (29 TD patients, 30 PIGD patients) healthy controls (HCs) were enrolled. ReHo analyzed via analysis of variance a two-sample t-test, with age sex as covariates. Correlations between clinical motor symptoms also examined. Distinct...
Chronic neuropathic pain is often refractory to current pharmacotherapies. The rodent Mas-related G-protein-coupled receptor subtype C (MrgC) shares substantial homogeneity with its human homologue, MrgX1, and located specifically in small-diameter dorsal root ganglion neurons. However, evidence regarding the role of MrgC chronic conditions has been disparate inconsistent. Accordingly, therapeutic value MrgX1 as a target for treatment humans remains uncertain. Here, we found that intrathecal...
Mas-related G-protein-coupled receptor subtype C (mouse MrgC11 and rat rMrgC), expressed specifically in small-diameter primary sensory neurons, may constitute a novel pain inhibitory mechanism. We have shown previously that intrathecal administration of MrgC-selective agonists can strongly attenuate persistent various animal models. However, the underlying mechanisms for MrgC agonist-induced analgesia remain elusive. Here, we conducted patch-clamp recordings to test effect on...
In this study, we sought to elucidate the molecular mechanism underlying human Mas-related G protein–coupled receptor X1 (MrgprX1)-mediated itch sensation. We found that activation of MrgprX1 by BAM8-22 triggered robust action potential discharges in dorsal root ganglion neurons. This neuronal excitability is not mediated transient (TRP) cation channels, M-type potassium or chloride channels. Instead, lowers threshold tetrodotoxin-resistant sodium channels and induces inward currents. These...
Abstract The aim of the study was to assess factors associated with periodic limb movements during sleep (PLMS) among obstructive apnea syndrome (OSAS) patients and identify role PLMS in OSAS. 303 adult OSAS were included study. All completed physical examination, Epworth sleepiness scale (ESS), polysomnography. Diagnosis made if leg index (PLMI) ≥ 15. Chi-square test, ANOVA, univariate multivariate logistic regression analyses conducted patients. Statistical performed SPSS 26.0 for mac....
Background Restless legs syndrome is an important sleep disturbance in Parkinson’s disease. causes urge to move the accompanying sensations which can be difficult describe but include aching, burning, tingling, or crawling. However, underlying pathophysiology of restless disease remains unknown and no imaging investigation has been conducted explore its mechanism date. Objective This study investigate brain functional changes with (PD-RLS + ) patients using magnetic resonance imaging....
The levels of MCF2L were detected by PCR and western blotting assay. effect on ferroptosis was confirmed MTT, colony formation assay, Brdu, in vivo animal experiment, the content Iron, GSH, ROS, MDA. underlying mechanisms explored PCR, blotting, affinity precipitation Our findings demonstrated that is remarkedly upregulated HCC tissues, sorafenib can induce MCF2L, suggesting might function resistance HCC. Further analysis showed downregulation enhances cell death induced sorafenib, inhibitor...
Background. The prognosis is poor for hepatocellular carcinoma (HCC), a tumor and cancer associated with inflammation that common. New data showed significant levels of KIAA1522 were expressed in HCC tissues cell lines, suggesting may be highly useful prognostic marker HCC. However, its biochemical processes impacts on the immune system go deeper. Objective. To verify significance investigate related carcinogenic mechanisms. Methods. Studies examining relationship between expression...
Vacuolar processing enzymes (VPEs) have been identified as the that regulate vacuole-mediated programmed cell death (PCD) in plants. The mechanism VPE regulates PCD rice aleurone layers remains unknown.The treated with distilled water exerted caspase-1 and activity, both of which were inhibited by specific inhibitor Ac-YVAD-CMK but not caspase-3 Ac-DEVD-CHO. However, inhibitors weakened activity caspase-3. Combined effects endogenous gibberellin (GA) on induction OsVPEs, we suggest OsVPE3...
Nociceptors in the dorsal root ganglia (DRG) and trigeminal ganglion (TG) play an essential role initiating pain by detecting painful stimuli through their peripheral axons sending signals to spinal cord via central [1]. Pathological conditions such as inflammation nerve injury can sensitize nociceptors, causing heightened sensitivity often leading chronic like TMJ disorders. Despite its importance understanding mechanism of nociceptor sensitization, monitoring neuronal activity nociceptors...
<title>Abstract</title> Objective To review and learn the knowledge of acute spinal cord injury(SCI), analyze feasibility advantages establishing a non-human primate model for injury with cynomolgus macaques. Method We selected female macaques to establish at specific segment spine hemisection. Before after modeling, muscle strength score, quantitative motor activity, as well blood biochemical routine indicators monkey was observed recorded evaluate effectiveness injury. Result In this...
Parkinson's disease is a commonly encountered central neurodegenerative in elder people. In recent years, considerable progresses have been made the etiopathogenesis and treatment of disease. But still, it cannot be prevented. No radical treatments found problems like adverse reactions to solved. According Jueyin six-meridian syndrome differentiation clinical manifestations disease, Professor Xiaodong Luo exploits differentiations tremor-spasm yin-yang, therefore creates effective basic...
Venovenous extracorporeal membrane oxygenation is effective for maintaining gas exchange in patients with respiratory failure or severe tracheal stenosis. Perioperative anesthetic management of airway obstruction can be associated ventilation intubation difficulties. Consequently, venovenous could an option treating such to avoid potential risks. However, only a limited number similar cases have been reported. Therefore, we summarized two provide theoretical and practical references stenosis...