A5101850489- Chemotherapy-induced cardiotoxicity and mitigation
- Pain Mechanisms and Treatments
- Cell death mechanisms and regulation
- Autophagy in Disease and Therapy
- Ion channel regulation and function
- Neuroscience and Neuropharmacology Research
- Cancer Treatment and Pharmacology
- Genetic and rare skin diseases.
- Inflammasome and immune disorders
- Rheumatoid Arthritis Research and Therapies
- Ectopic Pregnancy Diagnosis and Management
- Cytokine Signaling Pathways and Interactions
- Cancer, Stress, Anesthesia, and Immune Response
- Calpain Protease Function and Regulation
- Vascular Malformations and Hemangiomas
- Autoimmune and Inflammatory Disorders Research
- Nanoparticle-Based Drug Delivery
- Pancreatic function and diabetes
- Immune Response and Inflammation
- Mitochondrial Function and Pathology
- Cancer-related molecular mechanisms research
- Diabetes and associated disorders
- Liver Disease Diagnosis and Treatment
- Urinary Tract Infections Management
- Urinary Bladder and Prostate Research
Southern Methodist University
2025
Hospital Universitario Puerta de Hierro Majadahonda
2024
Third Hospital of Hebei Medical University
2021-2023
Hebei Medical University
2021-2023
Central South University
2021-2023
Capital Institute of Pediatrics
2023
Beijing University of Chinese Medicine
2022
Nanjing University of Chinese Medicine
2022
Soochow University
2022
First Affiliated Hospital of Soochow University
2022
Abstract Background Stimulator of IFN genes (STING) is highly expressed in the livers non-alcoholic fatty liver disease (NAFLD) patients and high fat diet (HFD) induced NAFLD mice model. The STING signaling-mediated inflammation has been shown to play a critical role metabolic disorders. Lingguizhugan decoction (LGZG), Traditional Chinese herbal decoction, applied treat disorders for many years. However, whether LGZG can alleviate progression through inhibiting remains unclear. This study...
Periodontitis is a chronic infectious disease, characterized by the progressive loss of teeth's supporting tissues, affecting almost 40% entire adult population. An imbalance between localized gram-negative infection and an exaggerated host inflammatory response plays pivotal role in determining gingival tissue damage. Recent evidence suggests that effect periodontitis might not be limited just to oral cavity but it have systemic consequences. Indeed has also been associated with moderate...
Doxorubicin (DOX) is one of the most effective chemotherapeutic agents. However, its clinical use limited due to severe risk cardiotoxicity. One hallmarks doxorubicin-induced cardiotoxicity (DICT) cascade mitophagy deficiency-mitochondrial oxidative injury-apoptosis, while so far, there no preventive strategy for alleviating DICT by targeting this molecular mechanism. Excitedly, based on our previous drug screen in zebrafish model, harpagoside (HAR) showed dramatic anti-DICT efficacy...
Paclitaxel is widely used as a first-line chemotherapy agent to treat malignant tumors. However, paclitaxel causes peripheral nerve fiber damage and neuropathic pain in some patients. In addition, patients received are often accompanied by negative emotions such anxiety. The amygdala critically involved regulating signals, well purpose of this study clarify the role Ca2+/calmodulin-dependent protein kinase II (CaMKII)-positive glutamatergic neurons paclitaxel-induced affective symptoms....
Paclitaxel (PTX) is a commonly used antitumor drug. Approximately 80% of all patients receiving PTX chemotherapy develop chemotherapy-induced peripheral neuropathy (CIPN), limiting the use PTX. Moreover, CIPN responds poorly to conventional analgesics. Experimental evidence suggests that neuroinflammatory response plays an essential role in paclitaxel-induced (PIPN). Previous studies have confirmed dorsal root ganglion (DRG) neuron necroptosis and accompanying inflammation are linked with...
Paclitaxel (PTX) chemotherapy treatment often leads to neuropathic pain, which is resistant available analgesic treatments. Death of cells and neuroinflammatory response are associated with PTX-induced peripheral neuropathy (PIPN). Necroptosis a form regulated necrotic cell death that accompanies strong inflammatory response. It mediated by receptor-interacting protein kinase 3 (RIP3) mixed-lineage domain-like (MLKL), contribute the pathogenesis several neurodegenerative diseases....
Abstract Autophagy, a well-observed intracellular lysosomal degradation process, is particularly important to the cell viability in diabetic cardiomyopathy (DCM). Peroxidasin (PXDN) heme-containing peroxidase that augments oxidative stress and plays an essential role cardiovascular diseases, while whether PXDN contributes pathogenesis of DCM remains unknown. Here we reported suppression autophagic flux, as shown by autophagosomes accumulation increased expression level LC3-II p62 cultured...
No AccessJournal of UrologyInvestigative urology1 Mar 2007Intravesical Suplatast Tosilate (IPD-1151T) Inhibits Experimental Bladder Inflammation W. Boucher, D. Kempuraj, J. Cao, Papaliodis, and T.C. Theoharides BoucherW. Boucher , KempurajD. Kempuraj CaoJ. Cao PapaliodisD. Papaliodis TheoharidesT.C. View All Author Informationhttps://doi.org/10.1016/j.juro.2006.10.036AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail...
Glial growth is a neuregulin‐1 isoform that mediates ERBB receptor signaling. It has been shown to improve left ventricular function in several models of heart failure, though the mechanisms are poorly understood. GGF2 regulates PI3 kinase (PI3K) and MAP (MAPK) as measured by pAKT pERK1/2 formation numerous cardiomyocyte models, including HL‐1, neonatal rat myocytes human iPSC‐derived cardiomyocytes. To better understand action stressed heart, we have developed vitro systems study protection...
Background: Female infertility is common and affects millions of couples worldwide. There growing recognition that infertility-associated factors are also risk for cardiovascular disease. However, women with arrhythmias have not been studied. Objectives: In this study, we aimed to investigate the association between female arrhythmias, determine potential in compared normal reproductive-aged women.Methods: This study was a bi-center retrospective infertile patients without incident...
Abstract The FK506-binding protein 51 (FKBP51, encoded by FKBP5 gene) has emerged as a critical regulator of mammalian endocrine stress responses and potential pharmacological target for metabolic disorders, including type 2 diabetes (T2D). However, in β cells, which secrete the only glucose-lowering hormone—insulin, expression function not been documented. Here, using human pancreatic tissue primary islets, we demonstrated abundant displayed an responsive induction upon acute inflammatory...
Neuregulin/erbB signalling is cardioprotective as seen in models of cardiotoxicity associated with the use chemotherapeutics.Our studies reveal a function Bcl-2 to protect cardiomyocytes concomitant GGF2-induced increases levels phospho-BAD (pBAD) along activation PI3 kinase (PI3K) and MAP (MAPK).We show that phosphorylation BAD dependent upon GGF2 mediated PI3K.In addition, examination mitochondrial gene expression shows several members family are down-regulated by doxorubicin, while able...
目的 通过对17例子宫瘢痕处妊娠(CSP)临床资料的分析，探讨其主要病因及有效的治疗方法。 方法 对17例CSP患者的临床资料进行回顾性分析。 结果 17例CSP患者平均年龄(32.6±6.6)岁；孕次≥3次15例；剖宫产次数≥2次8例；术前平均血HCG(54 093.8±42 509.4)mIU/mL；Ⅰ型CSP 14例，Ⅱ型CSP 3例；12例行宫腹腔镜联合监测下吸宫术，3例行宫腔镜下吸宫术，1例行B超监测下吸宫术，1例行经腹子宫瘢痕痕处妊娠楔形切除术，手术均顺利，均保留子宫，保留了生育功能；平均手术时间(68.4±35.2)min，术中平均出血量(70.6±93.6)mL；术后1～3周随访血HCG基本降至正常，达到治愈标准。 结论 CSP的发生与孕次及剖宫产次数关系密切，进行术前预处理(即术前采取米非司酮口服及单剂量一次使用MTX杀胚治疗，术前2 h米索前列醇400 μg纳阴)后行宫腹腔镜联合监测下吸宫术，对于子宫瘢痕处妊娠是一种安全、快捷、有效的治疗方法，值得临床推广和应用。
Purpose : To evaluate effects and mechanism of tofacitinib in treatment rheumatoid arthritis (RA) model rats. Materials Methods Dividing 27 rats into 3 groups: NC (normal control), Model (RA model) Tofacitinib treated with tofacitinib) groups. Observation joint swelling articular synovium pathology by HE staining, IL-1 β , IL-6, IL-10 TNF- α levels ELISA assay, JAK2, STAT3 NF- κ B(p65) proteins IHC WB assay. Results Compared group, swelling, histopathological score significantly deteriorated...