A5056313145- Psoriasis: Treatment and Pathogenesis
- Cytokine Signaling Pathways and Interactions
- IL-33, ST2, and ILC Pathways
- Parasites and Host Interactions
- Mast cells and histamine
- Parasitic Diseases Research and Treatment
- Neuroscience and Neuropharmacology Research
- Sleep and related disorders
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Sleep and Wakefulness Research
- Asthma and respiratory diseases
- Viral gastroenteritis research and epidemiology
- Menstrual Health and Disorders
- Antimicrobial Peptides and Activities
- Neuropeptides and Animal Physiology
- S100 Proteins and Annexins
- Eosinophilic Esophagitis
- Vitamin D Research Studies
- Trypanosoma species research and implications
- Vitamin C and Antioxidants Research
- Nerve injury and regeneration
- Immune Response and Inflammation
- melanin and skin pigmentation
- Immunotherapy and Immune Responses
Harry S. Truman Memorial Veterans' Hospital
2024
University of Missouri
2024
United States Department of Veterans Affairs
2024
Tufts University
2002-2008
Tufts Medical Center
2005-2008
Background and purpose: Allergic inflammation autoimmune diseases, such as atopic dermatitis, psoriasis multiple sclerosis (MS), involve both mast cell T‐cell activation. However, possible interactions between the two mechanism of activations are largely unknown. Experimental approach: Human umbilical cord blood‐derived cultured cells (hCBMCs) Jurkat T were incubated separately or together, following activation with myelin basic protein (MBP), well without pretreatment flavonoid luteolin for...
Periodontitis is a chronic infectious disease, characterized by the progressive loss of teeth's supporting tissues, affecting almost 40% entire adult population. An imbalance between localized gram-negative infection and an exaggerated host inflammatory response plays pivotal role in determining gingival tissue damage. Recent evidence suggests that effect periodontitis might not be limited just to oral cavity but it have systemic consequences. Indeed has also been associated with moderate...
Recently, we and others have shown that manipulating the activity of cholinergic interneurons (CIN) present in NAc can modulate binge alcohol consumption. The study is designed to examine relationship between consumption CIN real time by using an vivo microendoscopic technique. We hypothesized mice exposed Drinking Dark (DID)-a recognized mouse model for drinking-would exhibit increased accumbal shell region (NAcSh). To test this hypothesis, male expressing Cre-recombinase neurons were...
It has been reported that nervous system and peripheral immune communicate with each other the status is depressed in some intracranial tumor (ICT) patients pre operatively. Little known about of during post operative survival period. We thus investigated total T cells (CD 11 + ), helper/inducer (CD4 ) cells, suppressor/cytotoxic (CD8 B (CD19 serum immunoglobulins blood certain ICT before after treatment, based on histological type tumors. Post treatment analysis were conducted 30 days...
Hepatic encephalopathy (HE) is a neurological condition linked to liver failure. Acute HE (Type A) occurs with acute failure, while chronic C) tied cirrhosis and portal hypertension. treatments lag due gaps in understanding its development by gender age. We studied how sex age impact severity combined toxins. Our findings indicate that drug-induced (thioacetamide, TAA) brain edema was more severe aged males than young or young/aged female rats. However, adding alcohol (ethanol, EtOH) worsens...
Delayed pressure urticaria (DPU) is a skin condition that involves the gradual development of wheals and edema at sites physical pressure. Its pathogenesis not clear histamine-1 receptor (H-1R) antagonists provide only partial relief. In this prospective, clinical study, we investigated effect theophylline, which has long history benefit in allergic asthma, added to cetirizine patients with DPU. Twenty three received during period #1 (10 mg po QD) theophylline (200 BID) for 6 months,...
The objective of these studies is to review the role some parasites and their components in inflammation, allergy immune system. We also report recent results published by others group as well our own.
Fentanyl, a potent analgesic, and addictive substance, significantly impacts sleep-wakefulness (S-W). Acutely, it promotes wake whereas chronic abuse leads to severe sleep disruptions, including insomnia which contribute opioid use disorders (OUD), brain disease characterized by compulsive harmful consequences. Although the critical association between disruptions fentanyl addiction is acknowledged, precise mechanisms through influences remain elusive. Recent studies highlight role of...