A5101974009- Autophagy in Disease and Therapy
- Viral Infections and Immunology Research
- Nerve injury and regeneration
- IoT-based Smart Home Systems
- Bone Metabolism and Diseases
- interferon and immune responses
- Maritime Ports and Logistics
- Osteoarthritis Treatment and Mechanisms
- Adenosine and Purinergic Signaling
- Cytokine Signaling Pathways and Interactions
- S100 Proteins and Annexins
- TGF-β signaling in diseases
- Fire Detection and Safety Systems
- Gout, Hyperuricemia, Uric Acid
- PI3K/AKT/mTOR signaling in cancer
- Protein Tyrosine Phosphatases
- Cancer, Hypoxia, and Metabolism
- Liver Disease Diagnosis and Treatment
- Smart Grid Energy Management
- Natural Compounds in Disease Treatment
- Gut microbiota and health
- Methemoglobinemia and Tumor Lysis Syndrome
- Spinal Cord Injury Research
- NF-κB Signaling Pathways
- Silk-based biomaterials and applications
Jinan University
2015-2024
Shanghai Jiao Tong University
2024
Shanghai Sixth People's Hospital
2024
Harvard University
2024
Dana-Farber Cancer Institute
2024
Yangzhou University
2023
Lanzhou University
2022
Lanzhou University Second Hospital
2022
Wuhan University
2015-2021
University of California, San Diego
2018
The role of apoptosis in the pathogenesis intervertebral disc degeneration (IDD) remains enigmatic. Accumulating evidence has shown that apoptotic machinery is regulated by miRNAs. We hypothesized miRNAs might contribute to IDD. have found 29 were differentially expressed and miR-155 was down-regulated degenerative nucleus pulposus (NP). deregulation further verified using real-time PCR (0.56 fold, p < 0.05). Bioinformatics target prediction identified FADD caspase-3 as putative targets...
Silk fibroin is regarded as a natural fibrous protein with tunable mechanical properties, acceptable biocompatibility, and favorable capability of enhancing attachment, proliferation, differentiation chondrocytes. These properties make it suitable for the fabrication scaffolds broad range silk fibroin-based biomaterials cartilage regenerative therapy, which can heal functional without scar tissue. It be used single material making different kinds or composite other types biomaterials....
Chemokine interactions with their receptors have been implicated in hepatic stellate cell (HSC) activation. The expression of CXCR4 messenger RNA is increased hepatitis C cirrhotic livers and plasma levels its endogenous ligand, stromal cell-derived factor-1alpha (SDF-1alpha), correlate fibrosis these patients. by HSCs has not reported. We therefore examined whether express vivo vitro explored SDF-1alpha/CXCR4 receptor engagement promotes HSC activation, fibrogenesis, proliferation. protein...
Abstract Background Colony‐stimulating factor 1 receptor (CSF1R)‐related disorder (CRD) is a rare autosomal dominant disease. The clinical and genetic characteristics of Chinese patients have not been elucidated. Objective objective the study to clarify core features influence factors CRD in China. Methods Clinical genetic‐related data China were collected. Mini‐Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Sundal MRI Severity Score evaluated. Whole exome sequencing...
Hyperglycemia in diabetic mothers enhances the risk of fetal cardiac hypertrophy during gestation. However, mechanism high-glucose-induced is not largely understood. In this study, we first demonstrated that incidence rate dramatically increased fetuses using color ultrasound examination. addition, human was successfully mimicked a streptozotocin (STZ)-induced diabetes mouse model, which diagnosed type-M and histological assay. PH3 immunofluorescent staining hearts vitro-cultured H9c2 cells...
Growing evidence shows that the lungs are an unavoidable target organ of diabetic complications. However, pathologic mechanisms lung injury still controversial. This study demonstrated dysbiosis gut and microbiome, pulmonary alveolar wall thickening, fibrotic change in streptozotocin-induced mice antibiotic-induced compared with controls. In both animal models, NF-κB signaling pathway was activated lungs. Enhanced well thickening appeared transgenic expressing a constitutively active mutant...
Bone tissue engineering has become one of the most effective methods for treating bone defects. In this study, an electrospun membrane containing magnesium was successfully fabricated by incorporating oxide (MgO) nanoparticles into silk fibroin and polycaprolactone (SF/PCL)-blend scaffolds. The release kinetics Mg2+ effects on scaffold morphology, cellular behavior were investigated. obtained Mg-functionalized nanofibrous scaffolds displayed controlled Mg2+, satisfactory biocompatibility...
Damaged cartilage has very low regenerative potential which led to the search for novel tissue-engineering approaches help treat defects. While various have been reported, there is no perfect treatment currently. In this study we evaluated effects of a plant extract, chlorogenic acid (CGA), as part chondrocyte transplantation on model knee joint injury in chicks. First, primary cultured chondrocytes used evaluate CGA chondrogenesis. Then using an articular chick assessed functional recovery...
Frequent accidents have occurred in coal mine enterprises; therefore, raising the technological level of safety monitoring systems is an urgent problem. Wireless sensor networks (WSN), as a new field research, broad application prospects. This paper proposes Web Things- (WoT-) based remote system that takes full advantage wireless combination with CAN bus communication technique abstracts underground data and capabilities into WoT resources to offer services using representational state...
The Fanconi anemia ( FA ) pathway plays a key role in interstrand crosslink ICL repair and maintenance of the genomic stability, while inhibition this may sensitize cancer cells to DNA agents ionizing radiation IR ). active core complex acts as an E3 ligase monoubiquitinate FANCD 2, which is functional readout activated pathway. In present study, we aimed identify 2‐targeting agents, found that natural compound celastrol induced degradation 2 through ubiquitin–proteasome We demonstrated...
Entheses are regions where tendons and ligaments attach to bone, the primary target in seronegative other diseases of musculoskeletal (MSK) system. MRI has been widely used for visualizing features inflammatory degenerative MSK disease; however, normal entheses have short transverse relaxation times ( T 2 ), show little or no signal with conventional clinical pulse sequences, making it difficult investigate their MR properties. In this study we examined morphology cadaveric Achilles tendon...
Zinc oxide nanoparticles (ZnO NPs) have been increasingly and widely utilized in various fields, such as agriculture, food cosmetics. However, levels of adverse impacts ZnO NPs on the ecological environment public health associated with each stage their production, use disposal. can be ingested by pregnant women transferred to developing embryos/foetus through placental barrier, however, potential toxicity embryonic foetal development is largely unclear. In this study, we discovered that...
Abstract Host innate immunity is crucial for cellular responses against viral infection sensed by distinct pattern recognition receptors and endoplasmic reticulum (ER) stress. Enterovirus 71 (EV71) a causative agent of hand, foot, mouth disease neurological diseases. However, the exact mechanism underlying link between ER stress induced EV71 host largely unknown. In this study, we demonstrated that induces homocysteine-induced protein (HERP), modulator response which dependent on...
Abstract Mesenchymal stem cells homing and migration is a crucial step during bone fracture healing. Hypoxic environment in site induces marrow mesenchymal (BMSCs) migration, but its mechanism remains unclear. Our previous study studies by other groups have reported the involvement of signal transducer activator transcription 3 (STAT3) pathway cell migration. However, role STAT3 hypoxia‐induced still unknown. In this study, we investigated signaling BMSCs osteogenic differentiation. isolated...
Interleukin-34 (IL-34) has been recently identified as a novel cytokine, substituting for the function of macrophage colony-stimulating factor (M-CSF), pivotal osteoclastogenic involved in bone-related diseases (e.g., osteomyelitis jaws). However, molecular mechanisms are not fully understood. This study aimed to explore potential mechanism IL-34 receptor activator NF-kB ligand (RANKL)-induced osteoclast formation. We found that alone significantly maintained survival bone marrow macrophages...
Central heating is a sophisticated process, and many factors influence the loading for boilers; without comprehensively monitoring analysis, it difficult to find out potential hazards of substation supplying electrical equipment. This paper presents wireless machine based district solution that uses smart mobile devices in global network. In particular, focusing on design implementation GPRS-based multiserial data transmission terminals collect PLC/OPC substation, communication network used...
Abstract Background More than 60% of paroxysmal kinesigenic dyskinesia (PKD) cases are uncertain variants. Objective The aim was to elucidate novel genetic contribution PKD. Methods A total 476 probands with causes were enrolled for whole‐exome sequencing. method case–control analysis applied identify the candidate genes. Whole‐cell patch‐clamp recording verify electrophysiological impact identified mouse model cerebellar heterozygous knockout gene developed via adeno‐associated virus...