A5101440316- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Prenatal Screening and Diagnostics
- Hepatitis C virus research
- interferon and immune responses
- Neonatal Respiratory Health Research
- RNA regulation and disease
- Protein Tyrosine Phosphatases
- Preterm Birth and Chorioamnionitis
- Congenital Diaphragmatic Hernia Studies
- Assisted Reproductive Technology and Twin Pregnancy
- Cancer-related Molecular Pathways
- Viral Infections and Immunology Research
- Hemoglobinopathies and Related Disorders
- Reproductive Biology and Fertility
Jianghan University
2024
Wuhan University
2017-2020
Hainan Medical University
2019
Two billion people have been infected with HBV worldwide; about 240 million patients developed chronic hepatitis B (CHB), and 650,000 die each year from liver cirrhosis (LC) or hepatocellular carcinoma (HCC). This work elucidates a mechanism underlying the control of replication. infection activates HoxA10, regulator cell differentiation cancer progression, in human cells CHB HCC. HoxA10 subsequently inhibits replication tissue culture mice. Additionally, interacts p38 MAPK to repress...
Abstract Background Chorioamnionitis (CA) can cause multiple organ injuries in premature neonates, particularly to the lungs. Different opinions exist regarding impact of intrauterine inflammation on neonatal respiratory distress syndrome (NRDS) and bronchopulmonary dysplasia (BPD). We aim systematically review relationship between CA or Funisitis (FV) lung injury among preterm infants. Methods electronically searched PubMed, EMbase, Cochrane library, CNKI, CMB for cohort studies from their...
Abstract Host innate immunity is crucial for cellular responses against viral infection sensed by distinct pattern recognition receptors and endoplasmic reticulum (ER) stress. Enterovirus 71 (EV71) a causative agent of hand, foot, mouth disease neurological diseases. However, the exact mechanism underlying link between ER stress induced EV71 host largely unknown. In this study, we demonstrated that induces homocysteine-induced protein (HERP), modulator response which dependent on...
Hepatitis B virus (HBV) infection affects 364 million people worldwide and causes a serious global public health problem. The SRY-related high mobility group-box 9 (SOX9) is risk of developing cirrhosis in patients with chronic hepatitis cancer stem cell marker. However, the role SOX9 HBV replication has not been reported. This study revealed distinct mechanism underling regulation mediated by SOX9. induces mRNA protein expression human hepatoma cells, including HepG2.2.15, HepG2, Huh7,...
Objective: To analyze the frequency and spectrum of thalassemia mutations in amniotic fluid samples collected from Han Li people Hainan province China.Methods: We carried out a retrospective analysis on prenatal diagnosis pregnant women who may have next generation with high risks medium or severe between 2005 2016. Diverse fetal genotypes mutated alleles were analyzed cmpared.Results: examined 536 588 people, among which 406 500 found to carry at least one gene mutation, detection rate...