A5067612969- Traditional Chinese Medicine Analysis
- Cancer-related molecular mechanisms research
- Ginger and Zingiberaceae research
- Ginseng Biological Effects and Applications
- Medicinal Plant Pharmacodynamics Research
- Bioactive natural compounds
- Liver Disease Diagnosis and Treatment
- Pharmacological Effects of Natural Compounds
- Traditional Chinese Medicine Studies
- Food Quality and Safety Studies
- Liver physiology and pathology
- Toxin Mechanisms and Immunotoxins
- Cytokine Signaling Pathways and Interactions
- Asthma and respiratory diseases
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Phytochemistry and Biological Activities
- Immune Response and Inflammation
- Synthesis and biological activity
- Gout, Hyperuricemia, Uric Acid
- Natural product bioactivities and synthesis
- Metabolomics and Mass Spectrometry Studies
- Renal Diseases and Glomerulopathies
- Inflammasome and immune disorders
- Tryptophan and brain disorders
Anhui University of Traditional Chinese Medicine
2015-2025
Hunan Cancer Hospital
2024
Central South University
2024
Barro Colorado Island
2023
State Administration of Traditional Chinese Medicine of the People's Republic of China
2016
Anhui University
2013
LncRNA OIP5-AS1 has a common gene imbalance in various cancers and tumours, which plays an important role regulating its biological function. However, there are few studies on lncRNA rheumatoid arthritis (RA). The purpose of the present study was to investigate pathogenesis RA. In study, we established adjuvant (AA) rat model obtain primary fibroblast-like synoviocytes (FLSs);The subcellular localisation detected by fluorescence situ hybridisation (FISH) assay; Cell proliferation FLSs...
Background and aims Zingiber officinale Rosc (Dry ginger) Schisandra chinensis (Turcz.) Baill (Schisandra chinensis) drug pairs (DSP) are often used as for the treatment of asthma, these two traditional Chinese medicines (TCM) also core components multiple TCM. However, its specific pharmacological mechanism needs further research. The aim this study is to investigate effects DSP on intestinal flora bile acid metabolism in rats with asthma caused by cold, provide experimental evidence...
Bronchial asthma (BA) is a chronic inflammatory disease of the airway. Previous research has shown that Yanghe Pingchuan granules (YPGs) exert precise therapeutic effect on BA. In our previous work, we showed YPGs improved inflammation airways in rat models Other studies have pathogenesis BA closely related to pyroptosis and TOLL-like receptor pathway plays key role mediation pyroptosis. Therefore, present study, established model by applying concept used TLR4/NF-κB/NRLP3 signaling as target...
Abstract Introduction Previous studies have shown that Gandouling (GDL) may alleviate the nerve damage caused by Wilson's disease (WD) inhibiting autophagy of cell mitochondria. However, its mechanisms are still unclear. Revealing therapeutic mechanism GDL is beneficial for clinical application and provides theoretical support development new formulations treating WD. Method This time we found oxidative stress level in body copper‐overloaded WD rates increased, neurons hippocampus were...
To investigate the inhibitory effect of Panax notoginseng saponins (PNS) on liver fibrosis and explore underlying mechanisms. Carbon tetrachloride (CCl4)-treated rats hepatic stellate cells (HSCs) were used. The PNS CCl4-induced was studied with histochemical biochemical analysis. Transforming growth factor (TGF)-β1, α-smooth muscle actin (α-SMA), collagen I mRNA expression determined by reverse transcriptase-polymerase chain reaction (RT-PCR). Meanwhile, protein levels α-SMA, I,...
Dried ginger is the monarch drug in Linggan Wuwei Jiangxin (LGWWJX) decoction, which used to treat cold asthma. The purpose of this study was investigate and compare effects dried LGWWJX decoction for treatment asthma rats at metabolomics level using gas chromatography-mass spectrometry (GC-MS). OVA ice water-induced were induced SD rats. evaluated by general morphological observation, hematoxylin eosin staining, inflammatory cell count, IgE, IL-4, IFN-γ quantitation, visceral index....
Ethnopharmacological Relevance: Zishen Yutai pills (ZYP), a traditional Chinese patent medicine, was listed in China 1981. It is composed of 15 medicines and has the effects regulating menstruation, helping pregnancy, preventing abortion. In clinical practice, it effective habitual threatened miscarriages, continuing to explore its mechanism action very meaningful research. Aim Study: To possible ZYP promoting angiogenesis at maternal-fetal interface recurrent spontaneous abortion (RSA)....
Emodin has been shown to exert a renoprotective effect in diabetic nephropathy (DN). In this paper, we investigated whether circular RNAs (circRNAs) might be involved the mechanism of emodin DN. The levels malondialdehyde (MDA), reactive oxygen species (ROS), superoxide dismutase (SOD), interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) were measured using corresponding assay kits. expression circ_0000064, microRNA (miR)-30c-5p, large multifunctional protease 7 (Lmp7),...
The Stephania tetrandra−Astragalus membranaceus herbal pair (FH) is a classic widely used in the treatment of nephrotic syndrome (NS). effects tetrandra (FJ) and Astragalus (HQ) on NS have been reported, but mechanism their combination improvement are still unclear. model was established by injecting adriamycin into tail vein. FH intervention reduced levels serum triglyceride, total cholesterol, interleukin-6 (IL-6), blood urea nitrogen (BUN), urinary protein, gene expression aquaporin 2...
Rheumatoid arthritis (RA) is the most common autoimmune disease and affects multiple joints. Previous studies have shown that total saponins of Radix clematidis (TSC) a clear therapeutic effect on RA, but specific mechanism has not yet been clarified. Literature screening previous research suggest lncRNA OIP5-AS1/miR-410-3p/Wnt7b signaling pathway exerts regulatory pathogenesis RA. In this study, we examined whether TSC treatment RA pathway.Freund's complete adjuvant was used to create an...
Surgical treatment is playing an increasingly important role in the management of nasopharyngeal carcinoma (NPC). This consensus focuses on indications for optimal surgery, and surgical methods whole process NPC to provide a useful reference assist these difficult clinical decisions.
Abstract Background Yanghe Pingchuan decoction (YPD) has been used for asthma treatment many years in China. We sought to understand the mechanism of YPD, and find more potential targets YPD-based asthma. Methods An ovalbumin-induced model rats was created. Staining (hematoxylin eosin, Masson) evaluate effect YPD. RNA-sequencing carried out analyze global gene expression, differentially expressed genes (DEGs) were identified. Analysis functional enrichment done using Gene Ontology database...
To explore gingerol's potential mechanism for treating liver cancer using network pharmacology and molecular docking technology to conduct in-vitro experiments of human cell HepG2 verify important signalling pathways.We obtained targets gingerol derivatives (6-gingerol, 8-gingerol 10-gingerol) from PubChem SwissTargetPrediction websites collected related with the help GeneCards. We performed Gene Ontology (GO) Kyoto Encyclopedia Genes Genomes (KEGG) enrichment analysis on key DAVID data...
Previously, we demonstrated that Rhizoma Paridis saponins (RPS), the major active component of Paridis, may exhibit hepatoprotective effects. The present study aimed to identify potential mechanism RPS on hepatic injury and improvement in fibrosis (HF). A HF model was created Sprague‑Dawley rats by administration carbon tetrachloride. administered for treatment following creation model. protein mRNA expression vascular endothelial growth factor (VEGF), platelet‑derived (PDGF), extracellular...
Abstract Blood stasis syndrome (BSS) is the pathological basis of many cardiovascular diseases. Ginger often used as herbal medicine, condiment, and health food in China Southeast Asia to improve some symptoms disease, but its mechanism efficacy metabolic processes not clear enough. In this study, a rat model BSS was successfully established treated with different doses dried ginger extract. After end administration period, blood urine 5 groups rats were collected for metabonomic analysis....
Yanghe Pingchuan Granule (YPG) is a patented Chinese medicine developed independently by the Anhui Provincial Hospital of Traditional Medicine. For many years, it has been used for treatment asthma with remarkable clinical effects. However, composition YPG complex, and its potential active ingredients mechanism action are unknown. In this study, we investigated in through combination bioinformatics vivo experimental validation. We searched compounds targets from multiple databases obtained...
It is well known that troglitazone and voluntary running have the capacity to improve insulin resistance. The purpose of this study was evaluate combination effect on action. Female rats aged 7 weeks were divided into high-fat diet (HF), + (0.3% in diet; Tg), (for 3 wks; Tr), (Tg-Tr), control (C) groups. A sequential euglycemic clamp experiment with two different infusion rates 3.0 (L-clamp) 30.0 mU/kg BW/min (H-clamp) performed these after an overnight fast. Blood glucose concentrations...