Cinnamomi Ramulus‐Puerariae Lobatae Radix (CR‐PLR) possesses antidiabetic macrovascular pathology pharmacological effects, but its mechanism of action remains unclear. A total 197 CR‐PLR targets were identified with 1015 diabetic disease‐specific through network analysis, and 55 intersecting found. We screened five main active ingredients: Puerarin, 3'‐Methoxydaidzein, Cinnamaldehyde, Cinnamic acid Formononetin. The GO KEGG analyses showed that may ameliorate disease the AGE‐RAGE signaling...

A novel homogeneous polysaccharide, designated as PLPN-2, was screened from the dried root of Paeonia lactiflora Pall. using an activity-oriented approach, demonstrating remarkable anti-inflammatory properties. Structural analysis revealed that PLPN-2 is α-glucan comprising α-(1 → 4)-glucan backbone with α-Glcp-(1→/α-Glcp-(1 6)-β-Glcp-(1→ linked to at C-6. exhibited efficacy in alleviating inflammatory symptoms associated DSS-induced colitis mice and inhibiting release pro-inflammatory...

Polygonatum species, including P. cyrtonema, kingianum, and sibiricum, are edible plants with medicinal purposes, which have long been consumed as food due to their high nutritional value. In this study, polysaccharides from cyrtonema (PCP), kingianum (PKP) sibiricum (PSP) were obtained, physicochemical properties in vitro biological activities investigated. Our results demonstrated that PCP, PKP, PSP consist of major fructose minor glucose, galacturonic acid, galactose different molar...

Polygonatum cyrtonema Hua is cultivated for its edible and medical value. The steam-processed rhizome of P. the main form daily consumption it has been used traditionally in tonics treating various age-related disorders. aim our study was to compare physicochemical properties antioxidant activity polysaccharides respectively extracted from crude Cyrtonema (PCPC), (PCPS), explore a possible underlying mechanism.The PCPC with molecular weight 4.35 × 103 Da mainly consisted fructose trace...

The rhizome of Polygonatum sibiricum is traditionally used as a tonic-type edible herb. In this study, homogenous polysaccharide (PSPW) was isolated from P. sibiricum. PSPW primarily consisted fructose and glucose in molar ratio 18:1 with molecular weight 14.35 kDa. presented triple-helical conformation rough surface hill-shaped microstructure. Furthermore, after oral administration PSPW, the serum levels fasting blood glucose, glycosylated protein insulin were respectively decreased by...

Peony (Paeonia suffruticosa Andr) is an ornamental and medicinal plant in China. The root cortex of peony has been used traditional Chinese medicine for alleviating fever dissipating blood stasis. mainly produced Tongling, Anhui Province, China, it also called “Fengdan”. In November 2021, we collected plants with rot disease from several fields Tongling county, China (118°0'51" E, 30°48'11" N). Approximately 20 to 40 percent were affected the fields, which caused a decline quality yield this...

Cinnamomi Ramulus (CR) is the dried bark of Cinnamomum cassia Presl, Lauraceae. Puerariae Lobatae Radix (PLR) root Pueraria lobata (Wild.) Ohwi, Leguminosae. This Chinese herb couple come from classic formula "Gui Zhi Ge Gen Tang," which included in TCM "Treatise on Febrile Diseases." Our previous studies have found that CR related herbal compound and PLR are useful improving type 2 diabetes mellitus (T2DM), expected to be an antidiabetic candidate with fewer side effects. However mechanism...

One new pyrazine derivative, 4‐[(8′‐hydroxypyrazinyl)‐2′‐yl]‐1,3,3‐butanetriol (1), along with five known compounds (2‐6) were isolated from Zingiberis Rhizoma Praeparatum (ZRP). Their structures elucidated by 1D, 2D‐NMR, HR‐ESI‐MS spectroscopic data analysis, quantum chemical calculations of NMR Shifts (DP4+) and ECD calculation. Compounds 1‐2 5 demonstrated the protective effect on H2O2‐damaged human umbilical vein endothelial cells (HUVECs) within safe concentration range. Based results,...

The stems of Dendrobium huoshanense have long been used to prevent various diseases, including inflammatory diseases. This study was aimed explain the anti-inflammatory effect D. in LPS-induced RAW 264.7 macrophages and discover potential compounds. Results exhibited that ethanol extract could significantly inhibit production NO, TNF-α IL-1β. Based on bioassay guided strategy, four bibenzyls (1–4) were isolated from for first time. Anti-inflammatory assay showed 1–4 remarkably NO...

Gastrodia elata Blume was used to treat stroke and headaches caused by “Feng” for thousands of years. The present study has shown a significant effect G. in improving cerebral ischemia–reperfusion injury (CIRI). However, the mechanism CIRI regulating intestinal flora not been reported until now. This research aimed comprehensively evaluate based on fecal metabolomics 16S rDNA sequencing. rat model with created Zea Longa method. Enzyme-linked immunosorbent assay (ELISA) monitor inflammatory...

Background: Mangiferin (MA), a bioactive C-glucosyl xanthone with wide range of interesting therapeutic properties, has recently attracted considerable attention.However, its application in biomedicine is limited by poor solubility and bioavailability.Carbon dots (CDs), novel nanomaterials, have immense promise as carriers for improving the biopharmaceutical properties active components because their outstanding characteristics.Methods: In this study, water-soluble carbon dot (MC-CDs) was...

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Alzheimer's disease (AD) is a neurodegenerative disease, and neuroprotection an important approach to improving AD outcomes. Rhizoma of Anemarrhena asphodeloides (RAA) commonly used Traditional Chinese Medicine (TCM) with demonstrated neuroprotective effects, but its anti-AD mechanism requires further exploration. To elucidate the RAA on TMT-induced mice. The mice model was established via intraperitoneal injection TMT. effect ameliorating learning memory assessed using Morris Water Maze...

The Stephania tetrandra−Astragalus membranaceus herbal pair (FH) is a classic widely used in the treatment of nephrotic syndrome (NS). effects tetrandra (FJ) and Astragalus (HQ) on NS have been reported, but mechanism their combination improvement are still unclear. model was established by injecting adriamycin into tail vein. FH intervention reduced levels serum triglyceride, total cholesterol, interleukin-6 (IL-6), blood urea nitrogen (BUN), urinary protein, gene expression aquaporin 2...