A5061391281- Lymphoma Diagnosis and Treatment
- CAR-T cell therapy research
- Chronic Lymphocytic Leukemia Research
- Sperm and Testicular Function
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Venous Thromboembolism Diagnosis and Management
- Adipose Tissue and Metabolism
- Natural Compounds in Disease Treatment
- Healthcare and Venom Research
- Ovarian function and disorders
- Reproductive Biology and Fertility
- Phytochemistry and Biological Activities
- Polysaccharides and Plant Cell Walls
- Food Quality and Safety Studies
- Liver Disease Diagnosis and Treatment
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Pulmonary Hypertension Research and Treatments
- Ultrasound in Clinical Applications
- Acute Ischemic Stroke Management
- Asthma and respiratory diseases
- Complement system in diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Acute Lymphoblastic Leukemia research
- Lipid metabolism and biosynthesis
- Phytochemical and Pharmacological Studies
First Affiliated Hospital of Henan University of Science and Technology
2009-2025
Anhui University of Traditional Chinese Medicine
2012-2024
Genmab (United States)
2023-2024
First Affiliated Hospital of Henan University
2023
Ministry of Education of the People's Republic of China
2018
Bristol-Myers Squibb (United States)
2015-2017
Anhui Medical University
2012-2017
University of Vermont
2001
Human uterine leiomyomas (ULMs) are the most common neoplasms of women. Many genes dysregulated in ULMs and some this dysregulation may be due to abnormal expression micro-RNAs (miRNAs). In study, 55 matched myometrium were collected from 41 patients for microarray-based global miRNA analysis. Of 206 miRNAs examined, 45 significantly up- or down-regulated comparison (P < 0.001). The top five let-7 family, miR-21, miR-23b, miR-29b, miR-197. Four polycistronic clusters either down-regulated,...
Polygonatum cyrtonema Hua is cultivated for its edible and medical value. The steam-processed rhizome of P. the main form daily consumption it has been used traditionally in tonics treating various age-related disorders. aim our study was to compare physicochemical properties antioxidant activity polysaccharides respectively extracted from crude Cyrtonema (PCPC), (PCPS), explore a possible underlying mechanism.The PCPC with molecular weight 4.35 × 103 Da mainly consisted fructose trace...
The rhizome of Polygonatum sibiricum is traditionally used as a tonic-type edible herb. In this study, homogenous polysaccharide (PSPW) was isolated from P. sibiricum. PSPW primarily consisted fructose and glucose in molar ratio 18:1 with molecular weight 14.35 kDa. presented triple-helical conformation rough surface hill-shaped microstructure. Furthermore, after oral administration PSPW, the serum levels fasting blood glucose, glycosylated protein insulin were respectively decreased by...
Computed tomography (CT) scan is commonly performed for pleural effusion diagnostis in the clinic. However, there are limited data assessing accuracy of thoracic CT separation transudative from exudative effusions. The study aimed to determine diagnostic value distinguishing transudates exudates patients with effusion. This a two-center retrospective analysis effusion, total 209 were included First Affiliated Hospital Henan University Science and Technology as derivation cohort (Luoyang...
The relationship between serum albumin (ALB) and short-term prognosis in patients with acute pulmonary embolism (APE) remains unclear. We investigated the predictive value of ALB for APE using our hospital (PE) database (384 consecutively collected). Logistic regression analysis nomograms were applied to construct model, validation was assessed. A total 340 included, a 30-day all-cause mortality rate 8.5%. incidence hypoalbuminemia 15.9%. odds ratio (OR) high 0.89 (0.886, 95% CI:...
Despite new therapies for relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL), treatments with chemotherapy, single-agent rituximab/obinutuzumab, lenalidomide, combinations of these agents continue to be commonly used. This retrospective study utilized longitudinal data from 4226 real-world electronic health records characterize outcomes in patients R/R DLBCL. Eligible were diagnosed DLBCL between January 2010 and March 2022 had disease treated ≥ 1 prior systemic line therapy...
To study the effect of Wuziyanzong treatment on sperm quality and content calcium ions (Ca2+) in oligoasthenospermia rats. A model was induced 50 Sprague Dawley rats by with tripterygium glycosides at 30 mg/kg per day for 8 weeks. They were divided randomly into a group, positive group (Huangjingzanyu capsule, 3.01 g/kg), low, medium high dose groups (2.30, 4.60, 9.20 g/kg crude drug respectively) 10 each group. Another used as control The administered distilled water, while remaining d....
The function of white adipose tissue as an energy reservoir is impaired in obesity, leading to lipid spillover and ectopic deposition. Adipose inflammation can reduce the efficacy storage adipocytes by augmenting basal lipolysis through producing interleukin-6 (IL-6). Therefore, pharmacological compounds targeting or IL-6 signaling might have potential combat obesity. This study aims investigate impact Phillyrin, which frequently used for treating respiratory infections clinics China, on...
7552 Background: Outcomes have historically been poor for patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL). Despite an increase in approved R/R DLBCL treatment options, clinical outcomes of these therapies remain less certain. Novel treatments include chimeric antigen receptor T-cell (CAR T) therapy, polatuzumab vedotin plus bendamustine and rituximab (pola-BR), tafasitamab lenalidomide (tafa-len), loncastuximab (lonca), selinexor. The objective this study was to...
The present study aimed to explore the treatment effects of Taohongsiwu decoction on liver fibrosis in a rat model, as few prior studies have investigated anti-fibrotic decoction. High-performance liquid chromatography was used measure concentration ferulic acid and hydrosafflower flavin A Male Sprague-Dawley rats were randomly divided into control, colchicine (positive group), Taohongsiwu-high, Taohongsiwu-moderate Taohongsiwu-low groups; 50% carbon tetrachloride (CCl4) peanut oil solution...
A form of β-glucosidase was isolated and purified from fresh Chrysanthemum morifolium (Ramat.) Tzvel. 'Boju' (Boju) its enzymatic properties explored in this study. The enzyme Boju flavonoids were reacted a water bath to ascertain the composition reactants. Flavonoid glycoside aglycon concentrations varied significantly depending on processing method. concentration flavonoid glycosides decreased aglycons increased due heat-activation which hydrolyzed aglycons.