A5056476289- Immune Cell Function and Interaction
- Atherosclerosis and Cardiovascular Diseases
- Neuroinflammation and Neurodegeneration Mechanisms
- Chronic Obstructive Pulmonary Disease (COPD) Research
- IL-33, ST2, and ILC Pathways
- Diabetes and associated disorders
- T-cell and B-cell Immunology
- Respiratory viral infections research
- Cytomegalovirus and herpesvirus research
- Immune responses and vaccinations
- Single-cell and spatial transcriptomics
- SARS-CoV-2 and COVID-19 Research
- AI in Service Interactions
- Retinopathy of Prematurity Studies
- Acute Lymphoblastic Leukemia research
- Gastrointestinal Bleeding Diagnosis and Treatment
- Advanced Biosensing Techniques and Applications
- Nutrition, Genetics, and Disease
- Spam and Phishing Detection
- Influenza Virus Research Studies
- Colorectal Cancer Screening and Detection
- Sentiment Analysis and Opinion Mining
- Visual perception and processing mechanisms
- Pneumonia and Respiratory Infections
- Adipokines, Inflammation, and Metabolic Diseases
Regeneron (United States)
2024
University of Minnesota
2019-2023
Analysis Group (United States)
2023
Minnesota Department of Health
2020-2023
Twin Cities Orthopedics
2020-2022
University of Michigan–Ann Arbor
2022
University of Southern California
2022
University of Minnesota System
2022
Abstract Background Cellular changes in adaptive immune system accompany the process of aging and contribute to an aging-related phenotype (ARIP) characterized by decrease naïve T-cells (T N ) increase memory M ). A population-representative marker ARIP its associations with biological age-related chronic conditions have not been studied previously. Methods We developed two indicators based on well understood T cell distribution: /(T CM (Central Memory) + EM (Effector EFF (Effector))...
Socioeconomic and demographic factors including educational attainment, race ethnicity, childhood socioeconomic status (SES) are powerful predictors of inequalities in aging, morbidity, mortality. Immune accumulation late-differentiated, senescent-like lymphocytes lower levels naïve lymphocytes, may play a role the development age-related health inequalities. This study used nationally representative data from more than 9,000 US adults Health Retirement Study to investigate associations...
Abstract Purpose Validated algorithms (VAs) in insurance claims databases are often used to estimate the prevalence and incidence of comorbidities evaluate safety signals. However, although they then different data sources or subpopulations from those which were developed replicability these VAs rarely tested, making their application performance settings potentially unknown. This paper describes testing multiple identify incident breast cancer cases a general population an...
Abstract Traditional manual gating strategies are often time-intensive, place a high burden on the analyzer, and susceptible to bias between analyzers. Several automated methods have shown exceed performance of for limited number cell subsets. However, many algorithms still require significant interventions or yet demonstrate their utility in large datasets. Therefore, we developed an approach that utilizes previously published algorithm (OpenCyto framework) with manually created...
Abstract Background Circulating markers of oxidative stress have been associated with lower lung function. Our objective was to study the association gene expression levels pathway genes ( ALOX12 , ALOX15 ARG2 GSTT1 LPO MPO NDUFB3 PLA2G7 and SOD3) function forced expiratory volume in one second (FEV 1 ), vital capacity (FVC) Coronary Artery Risk Development Young Adults study. Methods Lung measured using spirometry Nanostring platform used estimate levels. Linear regression models were at...
Non-genetic factors are important but poorly understood determinants of immune profiles. Age and Cytomegalovirus (CMV) infection remain two well documented non-genetic the profile. Recently, one study identified cohabitation in same household as an determinant We used immunophenotyping data from Health Retirement Study (HRS) to evaluate association between adaptive (subsets T-cells, B-cells) innate profiles monocytes, natural killer cells neutrophils). compared cell using 1184 same-household...
Activation of toll-like receptors (TLR1, TLR5, TLR6) and downstream markers (CCR1, MAPK14, ICAM1) leads to increased systemic inflammation. Our objective was study the association between gene expression levels these six genes lung function (Forced Expiratory Volume in one second (FEV1), Forced Vital Capacity (FVC) FEV1/FVC). We studied Coronary Artery Risk Development Young Adults study. Spirometry testing used measure were measured using Nanostring platform. Multivariate linear regression...
Background: Life course socioeconomic and demographic factors including educational attainment, race ethnicity, childhood (SES) are very powerful predictors of large inequalities in aging, morbidity, mortality. Immune accumulation late-differentiated, senescent-like lymphocytes lower level naive lymphocytes, may play a role the development age-related health inequalities. However, there has been little research investigating association between status immune particularly changes lymphocyte...
An intelligent application is an instrumental driving force in retention and satisfaction of customers. Consertle would be one the first banking applications India that enables users to interact with through a chat bot specifically designed understand, interpret analyze user behavior so as provide better more efficient results. While bots itself are new introduction Indian financial system, customer instant query resolution.Currently, most visual medium which requires proceed various levels...
Abstract Immune cells distribution is shaped by numerous factors including environmental factors, age, and genetics. Cohabitation has been associated with similar microbiomes, possibly due to dietary patterns exposure pathogens but not studied in the context of adaptive innate immune systems previously. We used immunophenotyping data 2283 households participants living same household compared it randomly generated pairs from Health Retirement study. The (subsets T-cells B-cells), (monocytes,...
Abstract Cellular changes in the adaptive immune system accompanies aging process and contributes to an age-related phenotype (ARIP) characterized by decrease naïve T (TN) cells increase memory (TM) cells. However, a population level marker of ARIP associated with biological chronic conditions has not been evaluated previously. We developed two measures based on well understood age related cell distribution: TN/ (TCM (Central Memory) + TEM (Effector TEFF (Effector)) or TM CD4+ CD8+ compared...