Yonghai Zhang

ORCID: 0000-0003-3128-1338
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About
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Research Areas
  • Bladder and Urothelial Cancer Treatments
  • Kidney Stones and Urolithiasis Treatments
  • Amoebic Infections and Treatments
  • Urinary Tract Infections Management
  • Anesthesia and Sedative Agents
  • Urinary Bladder and Prostate Research
  • Congenital Anomalies and Fetal Surgery
  • Parasitic infections in humans and animals
  • Ferroptosis and cancer prognosis
  • Urinary and Genital Oncology Studies
  • Liver Disease Diagnosis and Treatment
  • Urological Disorders and Treatments
  • Paleopathology and ancient diseases
  • Esophageal Cancer Research and Treatment
  • Medical Research and Treatments
  • Renin-Angiotensin System Studies
  • Endometrial and Cervical Cancer Treatments
  • Colorectal Cancer Screening and Detection
  • Respiratory viral infections research
  • Flavonoids in Medical Research
  • Gout, Hyperuricemia, Uric Acid
  • Uterine Myomas and Treatments
  • Ureteral procedures and complications
  • Metabolomics and Mass Spectrometry Studies
  • Anesthesia and Pain Management

Shantou Central Hospital
2009-2025

Biruni University
2025

Universidad CES
2025

Sağlık Bilimleri Üniversitesi
2025

Ningxia Medical University
2020-2024

Nantong University
2020

Taizhou People's Hospital
2020

Qinghai Provincial Peoples Hospital
2018-2019

Sun Yat-sen University
2010

Abstract More than half of non‐muscle‐invasive bladder cancer (NMIBC) patients eventually relapse even if treated with surgery and BCG without optional bladder‐preserving therapy. This study aims to investigate the antitumor activity safety a HER2‐targeted antibody‐drug conjugate, RC48‐ADC, intravesical instillation for NMIBC treatment. In this preclinical study, it is revealed that human epidermal growth factor receptor 2 (HER2) expression scores 1+, 2+, 3+ are recorded 16.7%, 56.2%, 14.6%...

10.1002/advs.202302377 article EN cc-by Advanced Science 2023-10-12

Study Type – Therapy (RCT) Level of Evidence 1b What’s known on the subject? and What does study add? α‐blocker tamsulosin in medical expusion therapy was determined to be safe effective for distal ureteric stones with renal colic. This trial further demonstrates that MET is more efficative safer than nifedipine OBJECTIVE To determine comparative efficacy expulsive (MET) PATIENTS AND METHODS We evaluated a prospective randomized 3189 outpatients from 10 centres China. Eligible patients...

10.1111/j.1464-410x.2010.09801.x article EN BJU International 2010-11-17

Purpose To construct a predicting model for urosepsis risk patients with upper urinary tract calculi based on ultrasound and urinalysis. Materials Methods A retrospective study was conducted in admitted between January 2016 2020. The were randomly grouped into the training validation sets. set used to identify factors prediction test performance of artificial neural network (ANN). Results Ultimately, 1716 (10.8% cases 89.2% control) included. Eight variables selected model: sex, age, body...

10.1590/s1677-5538.ibju.2022.0450 article EN cc-by International braz j urol 2023-04-01

Objective: Lactylation is a type of chemical modification involving the introduction lactyl groups to molecule which can affect interactions between tumor cells and their microenvironment. This study aims evaluate possible role lactylation-related gene signature in prediction both prognosis immunotherapy response bladder cancer (BLCA). Methods: Lactylation-related genes were obtained from published work two subtypes (cluster A B) identified through unsupervised clustering. The differences...

10.4081/aiua.2025.13516 article EN cc-by-nc Archivio Italiano di Urologia e Andrologia 2025-02-17

To compare the safety and efficacy of retrograde intrarenal surgery (RIRS) vs minimally invasive percutaneous nephrolithotomy (mPCNL) in minimal management impacted upper ureteral stones along with evaluation predictive radiological parameters. A retrospective analysis was done 124 patients, undergoing RIRS (n:61) mPCNL (n:63) for stones. Both operative (success complication rates, time, postoperative hospital stay) (ureteral wall thickness, UWT), stone volume (SV), density (Hounsfield unit,...

10.4081/aiua.2025.13336 article EN Archivio Italiano di Urologia e Andrologia 2025-03-28

Inverse ratio ventilation theoretically increases oxygenation in obese patients. However, it is unknown whether the use of inverse prolongs safe apnea time during induction anesthesia. The primary objective our study was to compare between surgical patients receiving and conventional This a prospective, randomized controlled trial. Forty who underwent elective operation under general anesthesia with endotracheal intubation were randomly allocated into (CRV) group (n = 20) (IRV) 20). After...

10.3389/fmed.2025.1574634 article EN cc-by Frontiers in Medicine 2025-05-01

Previous studies have shown that endothelial nitric oxide synthase (eNOS) gene may be involved in abnormal semen parameters. However, the relationship between eNOS G894T polymorphism and parameters remains controversial. The purpose of this study was to investigate association genotype frequency determined 270 idiopathic asthenozoospermia patients 248 ethnically matched healthy volunteers using iPLEX genotyping assays on a MassARRAY(®) (Sequenom, San Diego, CA, USA) platform. statistical...

10.1111/and.12113 article EN Andrologia 2013-05-27

To evaluate the value of three-dimensional visualization technology for preoperative assessment liver autotransplantation end-stage hepatic alveolar echinococcosis.A total 8 patients with echinococcosis undergoing in Qinghai Provincial People's Hospital from May 2013 to July 2017 were collected. All cases received abdominal CT scanning and dynamic three-phase enhanced scanning, original data transferred human 3D virtual surgical planning system. The volumes Echinococcus multilocularis...

10.16250/j.32.1374.2018098 article EN PubMed 2018-04-26

Purpose: In China, the majority of hysteroscopic procedures require moderate sedation and analgesia. The efficacy intravenous lidocaine in reducing need for sedatives alleviating perioperative pain during hysteroscopy remains equivocal. This study aims to determine whether administration can reduce required dose propofol enhance management. Patients Methods: We conducted a prospective, single-center, double-blind randomized controlled trial involving patients with ASA I–II undergoing...

10.2147/dddt.s484486 article EN cc-by-nc Drug Design Development and Therapy 2024-12-01

To analyze the imaging manifestations of 79 cases hepatic echinococcosis retrospectively, so as to provide evidences for improving diagnosis and differential disease.Seventy-nine patients with who underwent examinations pathologic confirmation in Qinghai Provincial People's Hospital from 2014 2017 were chosen investigation objects, data their medical records collected analyzed.Among echinococcosis, 57 suffered cystic (CE) 22 alveolar (AE) . Among CE, those single type, multiple cysts...

10.16250/j.32.1374.2018121 article EN PubMed 2019-02-21

Objective Angiogenesis is essential for growth and recurrence of uterine leiomyomas, angiogenesis mediated by vascular endothelial factor C (VEGF-C) prostaglandin E2 (PGE 2 ). This study investigated whether spinal anesthesia (SA) with continuous postoperative epidural analgesia attenuates changes in these angiogenic factors compared general (GA) patient-controlled intravenous analgesia. Methods Forty-four women leiomyomas undergoing abdominal myomectomy were randomized to receive either...

10.1177/0300060520918420 article EN cc-by-nc Journal of International Medical Research 2020-04-01

Background:: microRNA-628-5p (miR-628-5p) has a significant impact on certain types of cancer. The precise function miR-628-5p in the context bladder urothelial carcinoma (BLCA) remains ambiguous. Objective:: We aimed to investigate role BLCA. Methods:: samples were collected from Cancer Genome Atlas (TCGA). Statistics employed evaluate correlation and predictive significance miR-628-5p. analyzed target genes regulatory network between immune infiltration. expression BLCA cells was confirmed...

10.2174/0113816128254621231017062923 article EN Current Pharmaceutical Design 2023-09-01

Purpose: To investigate the effect of chlorobenzoxime on respiratory syncytial virus (RSV) infection in vitro lung alveolar cells and vivo neonatal rats, as well mechanism action involved.
 Methods: RSV rats was induced via intranasal administration 2 x 106PFU viral particles. Reverse transcriptase-polymerase chain reaction (RT-PCR) western blotting were used for determination changes interleukin expression.
 Results: BEAS-2B caused significant reduction viability marked alteration...

10.4314/tjpr.v19i2.4 article EN cc-by Tropical Journal of Pharmaceutical Research 2020-04-09
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