A5065191449- Mass Spectrometry Techniques and Applications
- Electrochemical sensors and biosensors
- Advanced Proteomics Techniques and Applications
- Analytical chemistry methods development
- Monoclonal and Polyclonal Antibodies Research
- Advanced biosensing and bioanalysis techniques
- Glycosylation and Glycoproteins Research
- Microfluidic and Capillary Electrophoresis Applications
- Metal-Organic Frameworks: Synthesis and Applications
- Dendrimers and Hyperbranched Polymers
- Analytical Chemistry and Chromatography
- Electrochemical Analysis and Applications
- Heme Oxygenase-1 and Carbon Monoxide
- Advanced Chemical Sensor Technologies
- Cultural Industries and Urban Development
- Pharmacological Effects and Toxicity Studies
- Traditional Chinese Medicine Analysis
- Oral microbiology and periodontitis research
- Mesoporous Materials and Catalysis
- Supramolecular Self-Assembly in Materials
- Advanced Nanomaterials in Catalysis
- Biosensors and Analytical Detection
- Carbon and Quantum Dots Applications
- Salivary Gland Disorders and Functions
- Protease and Inhibitor Mechanisms
Jilin University
2011-2024
Union Hospital
2011-2024
Union Hospital
2017-2020
Hefei University of Technology
2013
Huazhong University of Science and Technology
2005
Dalian University
2005
Free bilirubin, a key biomarker for jaundice, was detected with newly designed fluorescent postsynthetically modified metal organic framework (MOF) (UIO-66-PSM) sensor. UiO-66-PSM prepared based on the aldimine condensation reaction of UiO-66-NH2 2,3,4-trihydroxybenzaldehyde. The fluorescence UIO-66-PSM could be effectively quenched by free bilirubin via resonant energy transfer process, thus achieving its recognition bilirubin. It first attempt to design MOF-based probe sensing exhibited...
Cyclodextrin molecular tube (CDMT), a new comer of cyclodextrin family, possesses large and hydrophilic outer area stable structure. Its development applications remain highly desired, especially in the field separation enrichment. Herein, we developed CDMT-based enrichment platform focusing on specific capture glycopeptides. To enhance hydrophilicity CDMT, it was functionalized with glutamate (glu). The prepared gluCDMT exhibited surface, high stability, good acidic/alkalic resistance. A...
We have studied the adsorption of p-aminophenol on poly(aryl ether ketone) containing pendant carboxyl groups (PEK-L). The pH effect, kinetics, isotherms, and thermodynamics are investigated in batch experiments. kinetics follows a pseudosecond-order model. Langmuir Freundlich isotherms employed to describe process, indicating that former fits data better. thermodynamic functions, ΔG°, ΔH°, ΔS° calculated. method is applied determination drug tablet samples, accuracy assessed through recovery
β-Cyclodextrin vesicles (CDVs) were first introduced into the polymer monolith to prepare a pH-responsive adsorption material and used for capture release of cardiac biomarker, myoglobin (Myo). SH-CDV was decorated with adamantane-modified SH-octapeptide enhance encapsulation rates Myo. Afterward, via click reaction produce monolith. Combining mass spectrometry detection, CDV-based enrichment Myo glycopeptides from mixture nonglycoprotein (bovine serum albumin) tryptsin digests reach up 1:10...
Herein, exfoliated Cu/Ga layered double hydroxide (LDH) nanosheets were constructed, over which Fe3O4 nanoparticles uniformly spread to maintain the two-dimensional (2D) morphology. The prepared Fe3O4-LDH exhibited high adsorption capacity (71.3 μmol g–1 for p-nitrophenylphosphate) and satisfactory enrichment selectivity (β-casein:BSA:ovalbumin ratio of 1:5000:5000). A low detection limit (0.01 fmol) was obtained β-casein phosphopeptides combined with MALDI-TOF MS determinations,...
Efficient removal of low density lipoprotein (LDL) is a key challenge due to its high level in plasma as primary risk factor the pathogenesis atherosclerotic cardiovascular disease. In this work, facile synthesis strategy based on host-guest interactions was developed prepare multilayer cucurbit[6]uril-based magnetic nanoparticles, MNPs-(HA-DAH5 /HA-CB[6]5 ). The compound employed blood purification material for LDL from because it had good compatibility and could be easily separated with an...
This study describes the enrichment ability of ZnO-modified methacrylic acid-co-ethylene dimethacrylate polymer monoliths as stationary phases for simultaneous determination antibiotics (ofloxacin, ciprofloxacin, enoxacin, and pefloxacin) combined with high-performance liquid chromatography. The prepared monolith was characterized by scanning electron microscopy, X-ray photoelectron spectroscopy, Fourier-transformed infrared thermogravimetric analysis. microextraction method has been applied...
A synthetic protocol for the preparation of an indium oxide nanoparticle-functionalized poly(methacrylic acid-glycidyl methacrylate-ethylene dimethacrylate-ethanediamine) monolithic column is reported. Various techniques, including scanning electron microscopy, transmission Fourier transform infrared spectroscopy, X-ray photoelectron and thermal gravimetric analysis-derivative thermogravimetric analysis were employed to characterize synthesized monolith. The modified was coupled with high...
Abstract Selective and efficient preconcentration is indispensable for low concentration of phosphopeptides in phosphorylated protein‐related samples prior to MS‐based analysis. Herein, an on‐chip system coupled magnetic SPE with MALDI‐TOF MS was designed. A metal oxide affinity chromatography material, indium oxide, coated on the surface Fe 3 O 4 nanoparticles prepare adsorbent, spatially confined applied field. The adsorbent exhibited high selectivity tryptic digests mixture β ‐casein BSA...
Biological-material-functionalized porous monoliths were prepared with lactoferrin and β-cyclodextrin via a click reaction. With the monolith as an extraction medium, method combined ICP-MS was developed for determination of total gallium originating from metabolic residues orally bioavailable complexes tris(8-quinolinolato)gallium (GaQ3) representative. The exhibited favorable adsorption behaviors high selectivity, low detection limit (2 ng L–1), enrichment factor 29-fold sample throughput...
Plasminogen (Plg) is a kind of glycoprotein which plays an important role in cell migration. The determination Plg content can directly reflect the abnormal manifestation fibrinolytic system dysfunctions. In present work, lysine (Lys)-based adsorbents were prepared for specific capture through covalent binding Lys with polymer monolithic substrate. was modified β-cyclodextrin (β-CD) via click reaction and anchored to substrate biotin by host-guest interaction. biotin-Lys-CD based material...
Abstract Immobilized metal affinity chromatography has drawn great attention as a widespread separation and purification approach. In this work, ruthenium was firstly introduced into the preparation of immobilized considering its to N,O‐donor ligands. A β‐cyclodextrin‐functionalized poly(glycidyl methacrylate‐ethylene dimethacrylate) monolith designed employed supporting material in chromatography. Thiosemicarbazide synthesis process, which not only acted bridge between β‐cyclodextrin...