A5101917331- CAR-T cell therapy research
- Telomeres, Telomerase, and Senescence
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Immunotherapy and Immune Responses
- Circular RNAs in diseases
- Biochemical Acid Research Studies
- vaccines and immunoinformatics approaches
- T-cell and B-cell Immunology
- MicroRNA in disease regulation
- Neurological Disorders and Treatments
- Peptidase Inhibition and Analysis
- Immune Cell Function and Interaction
- Gastric Cancer Management and Outcomes
- RNA modifications and cancer
- Neuroinflammation and Neurodegeneration Mechanisms
- Ferroptosis and cancer prognosis
- Malaria Research and Control
- Hepatocellular Carcinoma Treatment and Prognosis
- SARS-CoV-2 and COVID-19 Research
- Vitamin D Research Studies
- Lung Cancer Research Studies
- Neuroendocrine Tumor Research Advances
- Nuclear Receptors and Signaling
- Cancer, Stress, Anesthesia, and Immune Response
- Gastrointestinal Tumor Research and Treatment
Shanghai Jiao Tong University
2022-2024
Nanjing Medical University
2015-2024
University of California, Los Angeles
2016-2024
Air Force General Hospital PLA
2014-2024
Chinese PLA General Hospital
2013-2024
Shanghai Ninth People's Hospital
2024
Tulane University
2022-2023
Southwest Jiaotong University
2022-2023
Nanjing Agricultural University
2023
Henan Institute of Science and Technology
2020
Abstract To study whether TGF-β1/IL-11/MEK/ERK (TIME) signaling mediates senescence-associated pulmonary fibrosis (SAPF) in Bmi-1- deficient ( Bmi-1 −/− ) mice and determines the major downstream mediator of crosstalk between p16 INK4a reactive oxygen species that regulates SAPF, phenotypes were compared among 7-week-old double-knockout, N -acetylcysteine (NAC)-treated , wild-type mice. Pulmonary fibroblasts alveolar type II epithelial (AT2) cells used for experiments. Human tissues tested Ι...
Abstract To determine whether 1,25‐dihydroxyvitamin D (1,25(OH) 2 D) can exert an anti‐osteoporosis role through anti‐aging mechanisms, we analyzed the bone phenotype of mice with 1,25(OH) deficiency due to deletion enzyme, 25‐hydroxyvitamin 1α‐hydroxylase, while on a rescue diet. accelerated age‐related loss by activating p16/p19 senescence signaling pathway, inhibiting osteoblastic formation, and stimulating osteoclastic resorption, osteocyte senescence, senescence‐associated secretory...
Trans-differentiation from an adenocarcinoma to a small cell neuroendocrine state is associated with therapy resistance in multiple cancer types. To gain insight into the underlying molecular events of trans-differentiation, we perform multi-omics time course analysis pan-small model (termed PARCB), forward genetic transformation using human prostate basal cells and identify shared developmental, arc-like, entropy-high trajectory among all replicates. Further mapping single resolution...
Alternative splicing (AS) is prevalent in cancer, generating an extensive but largely unexplored repertoire of novel immunotherapy targets. We describe
The ability to selectively bind antigenic peptides and secrete effector molecules can define rare low-affinity populations of cells with therapeutic potential in emerging T cell receptor (TCR) immunotherapies. We leverage cavity-containing hydrogel microparticles, called nanovials, each coated peptide-major histocompatibility complex (pMHC) monomers isolate antigen-reactive cells. are captured activated by pMHCs inducing the secretion including IFN-γ granzyme B that accumulated on allowing...
Abstract Excessive production of reactive oxygen species (ROS) and inflammation are the key problems that impede diabetic wound healing. In particular, dressings with ROS scavenging capacity play a crucial role in process chronic Herein, Zr-based large-pore mesoporous metal–organic frameworks (mesoMOFs) were successfully developed for construction spatially organized cascade bioreactors. Natural superoxide dismutase (SOD) an artificial enzyme these hierarchical mesoMOFs, forming antioxidant...
Abstract Determining the mechanism of senescence‐associated pulmonary fibrosis is crucial for designing more effective treatments chronic lung diseases. This study aimed to determine following: whether Sirt1 and serum vitamin D decreased with physiological aging, promoting by activating TGF‐β1/IL‐11/MEK/ERK signaling, overexpression prevented signaling‐mediated in D‐deficient ( Cyp27b1 −/− ) mice, downregulated IL‐11 expression transcribed TGF‐β1/Smad2 signaling through deacetylating histone...
CAR (chimeric antigen receptor) T cell therapy has shown clinical success in treating hematological malignancies, but its treatment of solid tumors been limited. One major challenge is on-target, off-tumor toxicity, where cells also damage normal tissues that express the targeted antigen. To reduce this detrimental side-effect, Boolean-logic gates like AND-NOT have utilized an inhibitory (iCAR) to specifically curb activity at selected nonmalignant tissue sites. However, strategy seems...
Impaired apoptosis of fibroblast-like synoviocytes (FLSs) causes synovial hyperplasia, facilitating destruction cartilage and bone in rheumatoid arthritis (RA). Tumor necrosis factor (TNF)-α, a dominant inflammatory mediator RA pathogenesis, promotes progression symptoms. Prevalence 1, 25-dihydroxy-vitamin D3 (hereafter termed VD) deficiency is 30-63% patients with RA. Whether VD leads to or enhances TNF-α-mediated FLSs ameliorate unclear. To determine this, 10-week-old CYP27B1-deficient...
We examined the mutagenic specificity of widely used antibiotic ciprofloxacin (CPR), which displays weak to moderate activity in several bacteria and generates short in-frame deletions rpoB Staphylococcus aureus To determine spectrum mutations a system where any gene knockout would result recovered mutant, including frameshifts both long deletions, we CPR-induced thymidylate synthase-encoding thyA gene. Here, mutation resulting loss synthase trimethoprim (Trm) resistance. found that...
Abstract Aims Senescence‐associated pathological cardiac hypertrophy (SA‐PCH) is associated with upregulation of foetal genes, fibrosis, senescence‐associated secretory phenotype (SASP), dysfunction and increased morbidity mortality. Therefore, we conducted experiments to investigate whether GATA4 accumulation induces SA‐PCH, Bmi‐1‐RING1B promotes ubiquitination its selective autophagic degradation prevent SA‐PCH. Methods results Bmi‐1 ‐deficient ( −/− ), transgenic overexpressing Tg )...
Abstract Diabetic patients are prone to developing chronic inflammation after trauma and have persistent nonhealing wounds. Reactive oxygen species (ROS) recurrent bacterial infections at the site of long‐term wounds also further delay skin wound healing tissue regeneration. In this study, a granular gel (which exhibits ROS scavenging antibacterial properties) is fabricated based on hyaluronic acid‐ g ‐lipoic acid (HA‐LA). Briefly, HA‐LA synthesized fabricate microgels, which assembled by Ag...
Glucocorticoids (GCs) are steroidal hormones produced by the adrenal cortex. A physiological-level GCs have a crucial function in maintaining many cognitive processes, like cognition, memory, and mood, however, both insufficient excessive impair these functions. Although this phenomenon could be explained U-shape of GC effects, underlying mechanisms still not clear. Therefore, understanding may provide insight into treatments for mood-related disorders.
To explore the relationship of clinicopathological features and distribution neutrophils in tumor microenvironment with prognosis cholangiocarcinoma.Two hundred fifty-four formalin-fixed paraffin embedded tissue blocks were analyzed, including tissues from cholangiocarcinoma (n = 254), adjacent 238). Tissue sections stained for CD15 using immunohistochemical staining. expression was detected to identify local microenvironment. The neutrophil density reflect their inflammatory status....
In 2020, the Zambia National Malaria Elimination Centre targeted distribution of long-lasting insecticidal nets (LLINs) and indoor-residual spraying (IRS) campaigns based on sub-district micro-planning, where specified geographical areas at health facility catchment level were assigned to receive either LLINs or IRS. Using data from 2021 Indicator Survey (MIS), objectives this analysis (1) assess how well micro-planning was followed in distributing IRS, (2) investigate factors that...
As the scale, shape and function of engineering construction projects become more complex, design building systems has complex.In order to help students better acquire course resource information, effectively demonstrate teaching process, understand curriculum learn effectively, this paper designs an Auto CAD network architecture system.We analyze compare model based on system, introduce cluster analysis management.An was constructed through collaborative among professionals technology.We...
Physiologically aged lungs are prone to senescence-associated pulmonary diseases (SAPD). This study aimed determine the mechanism and subtype of T cells affecting alveolar type II epithelial (AT2) cells, which promote pathogenesis fibrosis (SAPF). Cell proportions, relationship between SAPD aging- secretory phenotype (SASP) young mice were analyzed using lung single-cell transcriptomics. was monitored by markers AT2 found be induced cells. Furthermore, IFNγ signaling pathways activated cell...
Cholangiocarcinoma is one of the most common malignancies in China. Surgical resection only treatment option; however, diagnosis at advanced stage precludes surgery. Comprehensive knowledge prognostic markers missing. Hence, aim this study was to determine clinicopathological indexes that would be indicative prognosis post-operative cases cholangiocarcinoma.A retrospective analysis 293 cholangiocarcinoma patients attending 301 Military Hospital Beijing, China between January 2004 and...
Significance T cell receptors (TCRs) surveil cellular environment by recognizing peptides presented the major histocompatibility complex. TCR sequencing allows for understanding scope of reactivity in health and disease. Specific clones can be used as therapeutics cancer autoimmune We present a technique that based on intracellular signaling molecules, such cytokines transcription factors. The core concept is highly generalizable should applicable to global gene expression analysis where...
Objectives The study aimed to evaluate the prognostic value of systemic inflammation markers [neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), Prognostic Nutritional Index (PNI)] and hepatic [aspartate aminotransferase-to-platelet index (APRI), γ-glutamyl transferase (γ-GT)/alanine aminotransferase (ALT)] in patients with hepatitis B virus (HBV)-associated hepatocellular carcinoma (HCC) further develop a novel score model.Methods A total 401 cases HBV-associated HCC who...