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Chia-Chun Chen

ORCID: 0000-0001-6169-952X
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About
Contact & Profiles
A5046032426
Research Areas
  • Immunotherapy and Immune Responses
  • Genomics and Chromatin Dynamics
  • Lung Cancer Research Studies

University of California, Los Angeles
 2023

 Temporal evolution reveals bifurcated lineages in aggressive neuroendocrine small cell prostate cancer trans-differentiation
OPENALEX - Publications 
Chia-Chun Chen Wendy Tran Kai Song Tyler Sugimoto Matthew B. Obusan and 20 more Liang Wang Katherine M. Sheu Donghui Cheng Lisa Ta Grigor Varuzhanyan Arthur Huang Runzhe Xu Yuanhong Zeng Amirreza Borujerdpur Nicholas Bayley Miyako Noguchi Zhiyuan Mao Colm Morrissey Eva Corey Peter S. Nelson Yue Zhao Jiaoti Huang Jung Wook Park Owen N. Witte Thomas G. Graeber

Trans-differentiation from an adenocarcinoma to a small cell neuroendocrine state is associated with therapy resistance in multiple cancer types. To gain insight into the underlying molecular events of trans-differentiation, we perform multi-omics time course analysis pan-small model (termed PARCB), forward genetic transformation using human prostate basal cells and identify shared developmental, arc-like, entropy-high trajectory among all replicates. Further mapping single resolution...

10.1016/j.ccell.2023.10.009 article EN cc-by-nc-nd Cancer Cell 2023-11-22
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