A5100394212- Hepatitis B Virus Studies
- Hepatitis C virus research
- Pancreatic and Hepatic Oncology Research
- Galectins and Cancer Biology
- Liver Disease Diagnosis and Treatment
- Immune Cell Function and Interaction
- T-cell and B-cell Immunology
- Signaling Pathways in Disease
- Antibiotic Use and Resistance
- Antibiotic Resistance in Bacteria
- Cancer Mechanisms and Therapy
- RNA Interference and Gene Delivery
- Toxin Mechanisms and Immunotoxins
- Hops Chemistry and Applications
- Cancer Immunotherapy and Biomarkers
- Complement system in diseases
- Viral Infections and Outbreaks Research
- Protein Tyrosine Phosphatases
- vaccines and immunoinformatics approaches
- Influenza Virus Research Studies
- Immune Response and Inflammation
- Immunotherapy and Immune Responses
- MicroRNA in disease regulation
- Peripheral Neuropathies and Disorders
- Urinary Tract Infections Management
Second Affiliated Hospital of Nanchang University
2023
Nanchang University
2023
First Affiliated Hospital of Xi'an Jiaotong University
2011-2020
National Natural Science Foundation of China
2016
University of Minnesota Medical Center
2013
Xiang Yang No.1 People's Hospital
2011
University of California, Los Angeles
2008
Dalian Medical University
2005
Tohoku Medical and Pharmaceutical University
2005
Immune checkpoint proteins programmed death-1 (PD-1) and T-cell immunoglobulin domain mucin containing molecule-3 (TIM-3) expression their gene polymorphisms have separately been shown to be associated with hepatitis B virus (HBV) infection hepatocellular carcinoma (HCC). This study simultaneously examined PD-1 TIM-3 in liver tissues PD1 TIM3 analyzed correlations 171 patients HBV-related HCC 34 cirrhosis. were by immunohistochemistry the genotypes of rs10204525 rs10053538 determined using...
// Guoyu Zhang 1 , Na Li Zhu Qianqian Fang Cuiling Yang Qunying Han Yi Lv 2,3 Zhihua Zhou Zhengwen Liu 1,3 Department of Infectious Diseases, First Affiliated Hospital, School Medicine, Xi'an Jiaotong University, Xi' an, Shaanxi, China 2 Hepatobiliary Surgery, Xi'an, 3 Institute Advanced Surgical Technology and Engineering, Correspondence to: Liu, email: Keywords : programmed cell death-1, 3'-untranslated region, single nucleotide polymorphism, microRNA, hepatitis B virus infection Received...
Upregulated T-cell immunoglobulin and mucin domain containing molecule-3 (Tim-3) in hepatitis B virus (HBV)-specific CD8+ T-cells contributes to exhaustion during chronic HBV infection. The membrane-bound Tim-3 can be cleaved from the cell surface by sheddase, yielding soluble (sTim-3). This study investigated serum sTim-3 levels patients with infection of various liver diseases.Serum were quantitatively determined 288 diseases. analyzed relation diseases including HBV-related hepatocellular...
Abstract Splenic CD8α+ dendritic cells reportedly tolerize T cell responses by inducing Fas ligand-mediated apoptosis, suppressing IL-2 expression, or catabolizing tryptophan reserves through expression of IDO. We report in this study that CD8α+, but not CD8α−, purified from the spleens normal mice can Th2 asthma phenotype more than one mechanism. This tolerance could largely be reversed vitro anti-IL-10 anti-TGFβ Ab treatment. However, loss direct cell-T contact also reduced tolerance,...
Influenza virus and other viruses use host cell surface sugars as receptors. Here we show that the sugar-binding domains in influenza hemagglutinin viral lectins share same structural fold human galectins (host lectins). Unlike easily accessible sites galectins, are hidden cavities. We propose these originated from but have evolved to evade immune attacks.
Programmed cell death protein 1 (PD-1) and T-cell immunoglobulin domain mucin containing molecule 3 (TIM-3) are involved in hepatitis B virus (HBV) infection hepatocellular carcinoma (HCC). This study examined the associations of PD1 TIM3 polymorphisms with overall survival (OS) a prospective cohort 258 HBV-related HCC patients. Results showed that +8669 G allele-containing genotypes or -1516 genotype GG were significantly associated longer OS (P < 0.001 P = 0.001, respectively). In...
Signal transducer and activator of transcription 3 (STAT3) is involved in hepatitis B virus (HBV) infection HBV-related hepatocellular carcinoma (HCC). The association between polymorphism rs1053005 haplotypes formed by rs1053004 the 3′UTR STAT3 chronic HBV has yet to be investigated. This study included 567 patients with (239 hepatitis, 141 liver cirrhosis 187 HCC), 98 resolvers, 169 healthy controls. polymorphisms were genotyped TaqMan SNP Genotyping Assays. genotype CC [P value Bonferroni...
Single-nucleotide polymorphisms (SNPs) in tumor necrosis factor alpha-inducible protein 3 (TNFAIP3) gene have been linked to inflammatory, immunological and malignant diseases. Hepatitis B virus (HBV) infection is characterized by immunopathogenesis. This study investigated the association of rs2230926, a nonsynonymous SNP TNFAIP3 gene, with chronic HBV infection. Four hundred fifty-five patients clinical diseases hepatitis (n = 183), liver cirrhosis 167) hepatocellular carcinoma 105), 92...
Chronic hepatitis B virus (HBV) infection remains an important public health issue. A20, a ubiquitin-editing protein encoded by tumor necrosis factor alpha-inducible 3 (TNFAIP3) gene, is complicated in HBV and liver injury. The tandem polymorphisms (rs148314165, rs200820567), deletion T followed to A transversion collectively referred as TT > TNFAIP3, may attenuate A20 expression.The rs148314165 rs200820567 were examined using PCR amplification direct sequencing 419 patients with chronic...
Background. With the wide use of antibiotics, antimicrobial resistance becomes a serious issue. Timely understanding microbial pathogen profiles and change provide an important guidance for effective optimized antibiotics in local healthcare systems. The aim was to investigate characteristics species their resistances tertiary hospital with Emergency Department outpatient clinics period six years. Methodology. A retrospective study conducted using HIS database between 2013 2018....
Thrombotic thrombocytopenic purpura (TTP), a rare and lethal thrombotic microangiopathy, is an autoimmune disease that can be triggered by viral infections such as COVID-19. This condition characterized hemolytic thrombocytopenia, neurologic alterations, possibly accompanied fever renal damage. Moreover, more than 220 patients with Guillain-Barré syndrome (GBS) have been reported in association the COVID-19 infection. In this report, we present case of patient who developed refractory TTP...
Abstract Objective: To assessing the characteristics of microbial species and antimicrobial resistance in a Tertiary Hospital with 49 outpatient clinics emergency department Northwestern China, six years. Methods: A retrospective study was conducted using HIS database tertiary hospital between full-year period 2013 2018. Antimicrobial susceptibility tests were by automated systems and/or Kary-Bauer disc diffusion method. Data analyzed WHONET 5.6 software. The Cochran–Armitage test used to...