A5104120222- Receptor Mechanisms and Signaling
- Ion Transport and Channel Regulation
- Vascular Malformations and Hemangiomas
- Molecular Sensors and Ion Detection
- Photoreceptor and optogenetics research
- Tracheal and airway disorders
- Neurobiology and Insect Physiology Research
- Olfactory and Sensory Function Studies
- Vascular Anomalies and Treatments
- ATP Synthase and ATPases Research
- Physiological and biochemical adaptations
Shandong University
2023-2025
Shenzhen Institutes of Advanced Technology
2024
Chinese Academy of Sciences
2024
Shenzhen Institute of Neuroscience
2024
<title>Abstract</title> Proton sensing by membrane G protein-coupled receptors (GPCRs) is crucial in controlling the breathing rate, bone formation, and cardiovascular kidney functions. However, structural basis mechanistic insights of proton sensing-induced GPCR activation remains unclear. Here, we report seven cryo-EM structures GPR4 GPR68, two well-known proton-sensing receptors, at different pH values complex with Gs or Gq trimers. Structural inspection, structure-based pKa calculations,...