A5101645306- Pneumonia and Respiratory Infections
- Dermatologic Treatments and Research
- Respiratory viral infections research
- Bacterial Infections and Vaccines
- Hemoglobinopathies and Related Disorders
- Bacterial Identification and Susceptibility Testing
- Pneumocystis jirovecii pneumonia detection and treatment
- Antibiotic Resistance in Bacteria
- Spine and Intervertebral Disc Pathology
- Laser Applications in Dentistry and Medicine
- Streptococcal Infections and Treatments
- RNA Research and Splicing
- Neonatal Health and Biochemistry
- Iron Metabolism and Disorders
- Cancer-related molecular mechanisms research
- Viral Infections and Outbreaks Research
- Parvovirus B19 Infection Studies
- Cervical and Thoracic Myelopathy
- Autoimmune and Inflammatory Disorders Research
- Infective Endocarditis Diagnosis and Management
- Circular RNAs in diseases
- Medical Imaging and Analysis
- Photodynamic Therapy Research Studies
- MicroRNA in disease regulation
- Acute Lymphoblastic Leukemia research
Shenzhen Children's Hospital
2011-2025
Shantou University
2024-2025
Shantou University Medical College
2024-2025
Ganzhou People's Hospital
2022-2025
Shanghai Jiao Tong University
2016-2023
Ruijin Hospital
2022-2023
Shanghai Ninth People's Hospital
2021-2022
Beijing Normal University
2008
Mackay Memorial Hospital
2001
Abstract Objectives To investigate the impact of COVID-19 pandemic measures on hospitalizations and alterations persistence epidemiological patterns 12 common respiratory pathogens in children during after cessation “zero-COVID-19” policy southern China. Methods Respiratory specimens were collected from hospitalized with acute infections at Shenzhen Children’s Hospital January 2020 to June 2024. Twelve detected using multiplex PCR. Data demographic characteristics, pathogen detection rates,...
Abstract Neonatal invasive candidiasis (NIC) has significant morbidity and mortality. Reports have shown a different profile of those neonates affected with NIC fluconazole-resistant Candida spp. isolates in low- middle-income countries (LMICs) compared to high-income (HICs). We describe the epidemiology, distribution, treatment, outcomes from LMICs enrolled global, prospective, longitudinal, observational cohort study (NeoOBS) hospitalized infants <60 days postnatal age sepsis...
The prevention and treatment of pathological scars remain challenging. Corticosteroids are the mainstay drugs in clinical scar as they effectively induce regression improve pruritus pain. Currently, intralesional injections corticosteroids widely used practice. These require professional medical manipulation; however, significant accompanying injection pain, repetition adverse effects, such skin atrophy, pigmentation telangiectasia, make this modality an unpleasant experience for patients....
Abstract A range of public health measures have been implemented to suppress local transmission coronavirus disease 2019 (COVID-19) in Shenzhen. We examined the effect these on prevalence respiratory pathogens children. Clinical and pathogen data were collected for routine care from hospitalized children with acute infections Shenzhen Children’s Hospital July 2018 January 2022. Nasopharyngeal swabs detected using standardized clinical diagnostics as part care. Data analyzed describe effects...
Development of new methods to screen early gastric cancer patients has great clinical requirement. Ten amino acids in human saliva are identified as small metabolite biomarkers distinguish and advanced from healthy persons by using high performance liquid chromatography-mass spectrometry (HPLC-MS). Then, surface enhanced Raman scattering (SERS) sensors based on graphene oxide nanoscrolls wrapped with gold nanoparticles developed detect ten saliva. The distinctive facilely prepared via...
The effect of SARS-CoV-2 on existing respiratory pathogens in circulation remains uncertain. This study aimed to assess the impact prevalence among hospitalized children.This enrolled children with acute infections Shenzhen Children's Hospital from September December 2019 (before COVID-19 epidemic) and those 2020 (during epidemic). Nasopharyngeal swabs were collected, detected using multiplex PCR. absolute case number detection rates 11 collected analyzed.A total 5696 tract infection...
Reactivation of fetal hemoglobin (Hb F, α2γ2) has been demonstrated to be a therapeutic strategy for patients with β-hemoglobinopathies. MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression by silencing RNA. Both coding and non-coding can compete the same miRNAs, acting as competing endogenous (ceRNAs). However, role ceRNAs in β-thalassemia major (β-TM) their impact on γ-globin remains poorly understood. In this study, we conducted transcriptome sequencing collect...
Bacterial infections often lead to severe health consequences owing their ability infiltrate multiple anatomical sites, including the bloodstream, respiratory tract, and digestive posing substantial diagnostic therapeutic challenges. Consequently, a rapid versatile detection method capable of identifying broad spectrum bacterial pathogens is urgently required facilitate precise antibiotic prescriptions. Addressing this need, we introduce MiND-DMF (Multibacterial Infection Nucleic Acid...
Abstract Language control in the bilingual brain has remained limelight of research over past decades. However, mechanisms underlying language may be more intricate than typically assumed due to hierarchical nature language. This study aimed investigate dynamics at phonetic level. Participants, who were speakers Chinese, English and German, named letters alphabet (L2) or German (L3) following an alternating language-switching paradigm. Two sets selected, differing phonological similarity...
Photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) is an alternative for hypertrophic scars (HS), which destroys human scar fibroblasts (HSF). However, the poor permeability of ALA both in HS tissue and HSF significantly restricts PDT HS. To overcome these barriers, ALA-loaded ethosomal vesicles (ALA-ES) were developed by a pH gradient active loading method characterized morphology, entrapment efficiency (EE) stability. Results show that prepared ALA-ES are homogenous spherical...
Synergistic transdermal photodynamic therapy (PDT)/photothermal (PTT) has emerged as a novel strategy for improving hypertrophic scar (HS) therapeutic outcomes. Herein, near-infrared heptamethine cyanine dye, named IR-808, been selected the desirable photosensitizer owing to its PDT and PTT properties. Benefitting from delivery ability of ethosomes (ESs), IR-808 loaded nanoethosomes (IR-808-ES) have prepared nanophotosensitizer PDT/PTT HSs. The special structure aggregate distribution in ES...
Photodynamic therapy (PDT) is a new therapeutic strategy for hypertrophic scars (HSs), and nanoethosomes (ES) have attracted considerable attention as an efficient transdermal delivery system PDT of HSs (HS-PDT). However, the photosensitizers hypoxic microenvironment limit HS-PDT efficacy. Consequently, functional ES (A/A-ES) that are loaded with photosensitizer, 5-aminolevulinic acid (ALA), immobilized nanoenzyme Au nanoclusters (ANCs) within surface been developed exhibit superior...
This study aimed to understand the impact of coronavirus disease 2019 (COVID-19) epidemic on distribution and antibiotic resistance pathogenic bacteria isolated from lower respiratory tract children in our hospital. Antimicrobial susceptibility tests were performed clinically tracts hospital 2018 2021 by Kirby–Bauer method automated systems. From 2021, top three clinical isolates Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae. These species showed obvious seasonal...
Introduction Samonella is 1 of 4 key global causes diarrhoeal diseases, sometimes it can be serious, especially for yong children. Due to the extensive resistance salmonella serotypes conventional first-line drugs, macrolides (such as azithromycin) have been designated most important antibiotics treatment . Antimicrobial a major public health problem in world, and mechanism azithromycin rarely studied. Methods This study determined plasmids Salmonella enterica isolates from children...
An increase in the levels of reactive oxygen species (ROS) and high expression transforming growth factor-β (TGF-β) wound tissue are two major problems for repair scar inhibition. Modulation microenvironment is considered to be able overcome these issues. Two possible solutions include use cerium oxide nanoparticles (CeO2) as an enzyme-like ROS scavenger pirfenidone (PFD) anti-fibrotic drug inhibit TGF-β. However, CeO2 easily adsorbed by biological macromolecules loses its activity....
To investigate the clinical characteristics and treatment of septic arthritis caused by Streptococcus pyogenes ( S. ) in children, we retrospectively analyzed data, laboratory results, treatments outcomes three pediatric cases occurring from 2016–2018. The included 1 boy 2 girls, aged 2–7 years. Two patients experienced fever, all cases, affected joints showed redness, swelling, an increased local skin temperature, tenderness restricted limb movement. At first visit, a significantly white...
Hypertrophic scars (HS) represent one of the most common clinical challenges due to unsatisfactory therapeutic results. HS formation is associated with abnormal activation fibroblasts and their excessive fibrotic behavior. Glycolysis dysregulation has been shown participate in incidence progression various diseases shows potential as a means controlling formation. This work aimed discuss impact augmented glycolysis on propose method for through regulation.Here, was confirmed together...
Abstract Urinary tract infections (UTIs) are common urological diseases that easily relapse and have led to an increasing economic health burdens. The China Antimicrobial Surveillance Network (CHINET) system is one of the most influential antimicrobial resistance surveillance networks in China. This study analyzed distribution trends uropathogens from 2015 2021 using CHINET system. A total 261,893 non-duplicate strains were collected; Gram-positive bacteria accounted for 23.8% while...
The emergence of ESBLs producing cephalosporin-resistant
To investigate the application of recombinant human bone morphogenetic protein-2 (RhBMP-2) in Percutaneous Endoscopic Posterior Lumbar Interbody Fusion (PE-PLIF). The study randomly included 102 patients with lumbar spondylosis who underwent PE-PLIF at our hospital from April 2020 to August 2022. Following random number table method, these subjects were graded as a group 51 cases and control cases. pedicle screw fixation treatment RhBMP-2 or autologous was given respectively. surgical status...
This study set out to determine the antimicrobial resistance trends of Haemophilus influenzae isolates from pediatric hospitals in Mainland China, which would provide basis for clinical treatment.The Infectious Disease Surveillance Pediatrics (ISPED) collaboration group conducted this study. H. strains isolated nine China were included. Disk diffusion method was used susceptibility test. Cefinase disc detection β-lactamase.In total, 13810 included during 2017-2019: 93.17% respiratory tract...
Emergence of plasmid-born mobile colistin resistance (mcr) gene, a growing concern in healthcare. Therefore, this study aims to genomically characterize multidrug-resistant Escherichia coli and Klebsiella pneumoniae co-harboring the mcr-1 mcr-3 genes young children. E. (n=3) K. (n=2) were collected from abdominal secretion blood, respectively. The isolates screened using tryptone soya broth (TSB) with 4µl/ml polymyxin-B. Growing bacteria identified VITEK-2 system, MALDI-TOF 16s RNA...