A5032035596- Advanced Breast Cancer Therapies
- Cancer Treatment and Pharmacology
- Breast Cancer Treatment Studies
- HER2/EGFR in Cancer Research
- Cancer Genomics and Diagnostics
- Cancer Cells and Metastasis
- Colorectal Cancer Treatments and Studies
- Cancer Immunotherapy and Biomarkers
- Chronic Lymphocytic Leukemia Research
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Cancer Diagnosis and Treatment
- Prostate Cancer Treatment and Research
- Pneumonia and Respiratory Infections
- Bacterial Infections and Vaccines
- Lung Cancer Research Studies
- Respiratory viral infections research
- Mycobacterium research and diagnosis
- BRCA gene mutations in cancer
- Peptidase Inhibition and Analysis
- Genomics and Phylogenetic Studies
- Cancer-related Molecular Pathways
- Mesenchymal stem cell research
- PARP inhibition in cancer therapy
- Estrogen and related hormone effects
Peking University
2015-2025
Peking University Cancer Hospital
2015-2025
Shenzhen Children's Hospital
2016-2024
National Center for Nanoscience and Technology
2018
UCSF Helen Diller Family Comprehensive Cancer Center
2018
University of California, San Francisco
2018
Guangzhou Institutes of Biomedicine and Health
2013
Chinese Academy of Sciences
2013
The prevalence of local dominant viral etiologies is important for clinical management and prevention common respiratory tract infections. Unfortunately, there limited large-scale data about infection in south China. To survey etiology seasonality acute infections hospitalized children, a 4-year consecutive study was conducted Shenzhen, Nasopharyngeal swab specimens were obtained from 30,443 children younger than 14 years with diseases Shenzhen Children's Hospital January 2012 to December...
Anti-angiogenesis offers an important treatment strategy for metastatic breast cancer (MBC). Metronomic chemotherapy (MCT) provides antiangiogenic effects without increased toxicities, making it good partner therapy. We conducted the present retrospective study to evaluate efficacy and safety of anlotinib plus MCT HER2 negative MBC. Patients with MBC who received metronomic (Vinorelbine (NVB), Capecitabine (CAPE), Etoposide (VP-16)) were retrospectively analyzed from Jan 2019 Dec 2021. The...
This study aims to explore the role of non-luminal disease score (NOLUS) for everolimus in patients with hormone receptor-positive and human epidermal growth factor receptor 2-negative (HR+/HER2-) advanced breast cancer (ABC). NOLUS has previously been established as an algorithm: (0-100) = - 0.45 × ER(%) 0.28 PR(%) + 0.27 Ki67(%) 73. Information was retrospectively collected from three centers China. Totally, 198 HR+/HER2- ABC complete records expression rates (%) ER, PR Ki67 were enrolled...
Abstract Background Cyclin‐dependent kinase (CDK) 4/6 inhibitor plus endocrine therapy (ET) become standard‐of‐care for patients with hormone receptor‐positive, human epidermal growth factor receptor‐2 negative (HR+/HER2−) metastatic breast cancer (MBC). However, the optimal therapeutic paradigm after progression on CDK4/6 remains unclear. This study aimed to evaluate efficacy and safety of abemaciclib switching ET versus chemotherapy prior palbociclib‐based in Chinese HR+/HER2− MBC. Methods...
Hepatitis C virus (HCV) is a major cause of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma in humans. The life cycle HCV closely associated with the metabolism lipids, especially very-low-density lipoprotein (VLDL) hepatocytes. Hepatocyte nuclear factor 4α (HNF4α), most abundant transcription liver, regulates VLDL secretory pathway. However, effects HNF4α on are unclear. In this study, we investigated regulatory assembly secretion. HNF4α-deficient hepatocytes showed reduced...
This study aimed to understand the impact of coronavirus disease 2019 (COVID-19) epidemic on distribution and antibiotic resistance pathogenic bacteria isolated from lower respiratory tract children in our hospital. Antimicrobial susceptibility tests were performed clinically tracts hospital 2018 2021 by Kirby–Bauer method automated systems. From 2021, top three clinical isolates Streptococcus pneumoniae, Moraxella catarrhalis, Haemophilus influenzae. These species showed obvious seasonal...
Background: The presence of a high neutrophil-to-lymphocyte ratio (NLR) has been associated with increased mortality in several malignancies. And the majority studies on breast cancer (BC) analyzed patients early-stage. Fewer focused metastatic BC (MBC). De novo stage IV no prior treatment is more suitable for analyzing prognostic factors. Herein, we examined value baseline NLR de patients.
Background This study was conducted to describe present and changing trends in surgical modalities neoadjuvant chemotherapy (NACT) female breast cancer patients China from 2006 2015. Methods Data of 44 299 15 tertiary hospitals Beijing were extracted hospitalization summary reports. Surgeries categorized into five modalities: breast‐conserving surgery (BCS), simple mastectomy (SM), modified radical (MRM), (RM), extensive (ERM). Results In total, 38 471 (86.84%) underwent surgery: 22.64% BCS,...
We aimed to clarify tumor features and prognosis of pregnancy-associated breast cancer (PABC) among Chinese women.PABC was defined as diagnosed during pregnancy or within a year after delivery. Patients with PABC were selected from cases women ≤45 years treated at our institution between December 2012 2017, one non-PABC control matched for stage, age, diagnosis each case.Forty-one identified (22 19 1 delivery). There significantly more progesterone receptor (PR)- triple-negative tumors in...
Abstract Objective: Triple-negative breast cancer (TNBC) is a heterogeneous disease with poor prognosis. Circulating tumor cells (CTCs) are promising predictor for prognoses but their reliability regarding progression-free survival (PFS) controversial. We aim to verify predictive value in TNBC. Methods: In present prospective cohort study, we used the Pep@MNPs method enumerate CTCs baseline blood samples from 75 patients TNBC (taken at inclusion this study) and analyzed correlations between...
This study aimed to examine the prognostic value of neutrophil-to-lymphocyte ratio (NLR) and other clinicopathological features in HER2+ MBC patients who received first-line anti-HER2 therapy. A total 129 were assigned NLR-low NLR-high groups based on a cutoff 3.0 at baseline. Peripheral blood lymphocyte subsets gene mutations circulating tumor DNA analyzed by flow cytometry Next-generation sequencing, respectively. Survival was evaluated Kaplan−Meier method Cox regression analysis. Of...
Abstract Purpose To evaluate the efficacy and safety of pegylated liposomal doxorubicin (PLD) in patients with human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC) heavily pretreated anthracycline taxanes. Methods In this single-arm, phase II study, HER2-negative MBC previously treated taxanes as second- to fifth chemotherapy received PLD (Duomeisu ® , generic hydrochloride liposome) 40 mg/m every 4 weeks until disease progression, unacceptable toxicity, or...
<sec><b>Objective</b>To compare the efficacy of platinum- and non-platinum-based regimens as first-line treatment for advanced triple-negative breast cancer (TNBC) analyze relationship between their <i>BRCA</i> gene status.</sec><sec><b>Methods</b>Retrospectively clinical data 220 patients diagnosed pathologically with TNBC treated at Department Breast Oncology, Peking University Cancer Hospital from 2013 to 2018 evaluate chemotherapy. A total 114 had <i>BRCA1</i>/<i>2</i> tested by next...
Abstract Purpose In patients with first-line advanced breast cancer (ABC), the correlation between ctDNA variant allele frequency (VAF) and tumor disease burden, its prognostic value remains poorly investigated. Methods This study included ABC diagnosed at Peking University Cancer Hospital who performed test before receiving treatment. Baseline plasma samples were collected for assessing alterations VAF next-generation sequencing. The sum of target lesion diameters (SLD) was measured imaging...
Introduction Rapid identification of infected individuals through viral RNA or antigen detection followed by effective personal isolation is usually the most way to prevent spread a newly emerging virus. Large-scale involves mass specimen collection and transportation. For biosafety reasons, denaturing transport medium has been extensively used during SARS-CoV-2 pandemic. However, high concentrations guanidinium isothiocyanate (GITC) in such media have raised issues around sufficient GITC...
Abstract Background Infectious meningitis/encephalitis (IM) is a severe neurological disease that can be caused by bacterial, viral, and fungal pathogens. IM suffers high morbidity, mortality, sequelae in childhood. Metagenomic next-generation sequencing (mNGS) potentially improve outcomes both pathogen host responses increasing the diagnosis accuracy. Methods Here we developed an optimized mNGS pipeline named comprehensive (c-mNGS) to monitor DNA/RNA pathogens simultaneously applied it 142...
Background: Fulvestrant 500mg has proved its clinical effectiveness in previous trials as primary or second line treatment of hormone receptor positive, human epidermal 2 negative (HR+/HER2˗) post-menopausal advanced breast cancer.This real-world study aimed to investigate the efficacy and safety HR+/HER2˗ Chinese cancer patients.Method: patients who received from January 2015 December 2018 Beijing Cancer Hospital were enrolled this retrospective study.Progression free survival (PFS),...