A5066100981- Epigenetics and DNA Methylation
- X-ray Diffraction in Crystallography
- Birth, Development, and Health
- Crystallization and Solubility Studies
- MicroRNA in disease regulation
- Electrospun Nanofibers in Biomedical Applications
- Advanced SAR Imaging Techniques
- biodegradable polymer synthesis and properties
- Health, Environment, Cognitive Aging
- Gut microbiota and health
- Advanced Cellulose Research Studies
- Dysphagia Assessment and Management
- Intergenerational Family Dynamics and Caregiving
- Advancements in Battery Materials
- Cancer-related molecular mechanisms research
- Traumatic Brain Injury Research
- Synthetic Aperture Radar (SAR) Applications and Techniques
- Synthetic Organic Chemistry Methods
- Posttraumatic Stress Disorder Research
- Food Security and Health in Diverse Populations
- RNA modifications and cancer
- Health disparities and outcomes
- Health, psychology, and well-being
- demographic modeling and climate adaptation
- Conducting polymers and applications
Guangdong Academy of Medical Sciences
2025
Southern Medical University
2025
Guangdong Provincial People's Hospital
2025
Harvard University
2019-2025
Henan University
2025
Guangdong University of Petrochemical Technology
2025
Xinjiang Institute of Ecology and Geography
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2023-2025
Tianjin University of Science and Technology
2021-2024
Singapore General Hospital
2024
Abstract Wearable sensor has attracted a broad interesting in application prospect of human‐machine interaction (HMI). However, most sensors are assembled the shape gloves to accurately capture complex hand motion information, thereby seriously blocking complete tasks. Herein, wearable pressure based on drum‐structured triboelectric nanogenerator (DS‐TENG) is developed subtle signals for physiological signal detection, information encoding, gesture recognition, and wireless real‐time robot...
DNA methylation (DNAm) clocks are important biomarkers of cellular aging and associated with a variety age-related chronic diseases all-cause mortality. Examining the relationship between education lifestyle risk factors for multiple DNAm can increase understanding how contribute to at level. This study explored association or acceleration four clocks, including intrinsic (IEAA) extrinsic epigenetic age (EEAA), PhenoAge (PhenoAA), GrimAge (GrimAA) in African American participants Genetic...
Abstract Differently to most chemically synthesized medical materials, polyhydroxyalkanoates (PHAs) are intracellular carbon and energy storage granules, which is a family of natural bio‐polymers by microorganism's materials. Due excellent biocompatibility reasonable biodegradability versatile material difference, PHAs well biomaterials candidates for applications in tissue engineering drug delivery, including commercial PHB, PHBV, PHBHHx, PHBVHHx, P34HB few uncommercial PHAs....
Cigarette smoking has been associated with adverse health outcomes for mothers and children is a major contributor to heart disease. Although cigarette known affect the epigenome, few studies have done in African American populations. In this study, we investigated association between DNA methylation (DNAm) among Americans from Intergenerational Impact of Genetic Psychological Factors on Blood Pressure Study (InterGEN), Epidemiology Network Arteriopathy (GENOA). The InterGEN study aims...
<h3>Importance</h3> Posttraumatic stress disorder (PTSD) has been hypothesized to lead impaired cognitive function. However, no large-scale studies have assessed whether PTSD is prospectively associated with decline in middle-aged adults. <h3>Objective</h3> To assess the association between and function over time. <h3>Design, Setting, Participants</h3> This cohort study included participants from Nurses' Health Study II, an ongoing longitudinal involving community-dwelling female nurses...
Anti-angiogenesis offers an important treatment strategy for metastatic breast cancer (MBC). Metronomic chemotherapy (MCT) provides antiangiogenic effects without increased toxicities, making it good partner therapy. We conducted the present retrospective study to evaluate efficacy and safety of anlotinib plus MCT HER2 negative MBC. Patients with MBC who received metronomic (Vinorelbine (NVB), Capecitabine (CAPE), Etoposide (VP-16)) were retrospectively analyzed from Jan 2019 Dec 2021. The...
Chronic cerebral hypoperfusion (CCH) is a critical pathophysiological mechanism underlying small vessel disease (CSVD). Accumulating evidence have demonstrated that resident pericytes and deposit extracellular matrix (ECM) play key role in mediating fibrosis hypoxic changes. Edaravone dexborneol (EDB) known to target multiple pathways involved fibrosis. We constructed the CCH mouse models were subjected either PBS or EDB at different concentrations. Measures of cognitive function, neuronal...
Gene duplication, as a prevalent phenomenon in the tree of life, provides potential substrate for evolution. However, its role Aurantioideae remains unclear. In this study, we systematically identified, first time, comprehensive landscape five types gene duplication genomes 26 species within Aurantioideae, focusing on dissecting patterns, their evolutionary significance, and impact function expression. Our results showed that tandem (TD) was predominant type confirmed shared ancient...
Genetic variations in apolipoprotein E (APOE) and proximal genes (PVRL2, TOMM40, APOC1) are associated with cognitive function dementia, particularly Alzheimer's disease. Epigenetic mechanisms such as DNA methylation play a central role the regulation of gene expression. Recent studies have found evidence that may contribute to pathogenesis but its association populations without dementia remains unclear. We assessed levels 48 CpG sites APOE genomic region peripheral blood leukocytes...
The mechanism of dsRNA-induced gene activation (RNAa) is being gradually unveiled. plentiful evidence that it existed in mammalian species other than human demonstrated dsRNA-mediated RNAa a conservative phenomenon. Simultaneously, accumulating suggested microRNAs could activate expression by targeting promoter. Nevertheless, ambiguous whether microRNA-induced different cells common study we performed verified miR-1236-3p (miR-1236) and miR-370-5p can p21 bladder cancer (BCa) T24, EJ cells,...
Abstract Background Epigenetic age acceleration, a measure of biological aging based on DNA methylation, is associated with cardiovascular mortality. However, little known about its relationship hypertensive target organ damage to the heart, kidneys, brain, and peripheral arteries. Methods We investigated associations between intrinsic (IEAA) or extrinsic (EEAA) epigenetic blood pressure, six types in primarily cohort 1390 African Americans from Genetic Epidemiology Network Arteriopathy...