A5028893940- biodegradable polymer synthesis and properties
- Bone Tissue Engineering Materials
- Graphene and Nanomaterials Applications
- SARS-CoV-2 and COVID-19 Research
- Collagen: Extraction and Characterization
- Protein Hydrolysis and Bioactive Peptides
- Animal Virus Infections Studies
- Spaceflight effects on biology
- Immunotherapy and Immune Responses
- Space Exploration and Technology
- Electrospun Nanofibers in Biomedical Applications
- Bone and Dental Protein Studies
Northwest University
2020-2021
Ministry of Education of the People's Republic of China
2020-2021
Hydrophilic bone morphogenetic protein 2 (BMP2) is easily degraded and difficult to load onto hydrophobic carrier materials, which limits the application of polyester materials in tissue engineering. Based on soybean-lecithin as an adjuvant biosurfactant, we designed a novel cell-free-scaffold polymer poly(ε-caprolactone) poly(lactide-co-glycolide)-co-polyetherimide with abundant entrapped continuously released BMP2 for vivo stem cell-capture situ osteogenic induction, avoiding use exogenous...
Abstract Differently to most chemically synthesized medical materials, polyhydroxyalkanoates (PHAs) are intracellular carbon and energy storage granules, which is a family of natural bio‐polymers by microorganism's materials. Due excellent biocompatibility reasonable biodegradability versatile material difference, PHAs well biomaterials candidates for applications in tissue engineering drug delivery, including commercial PHB, PHBV, PHBHHx, PHBVHHx, P34HB few uncommercial PHAs....
An efficient long-term intracellular growth factor release system in simulated microgravity for osteogenic differentiation was prepared based on polylactic acid (PLA) and polyhydroxyalkanoate (PHA) nanoparticles (NPs) loading of bone morphogenetic protein 2 (BMP2) 7 (BMP7) (defined as sB2-PLA-NPs sB7-PHA-NPs), respectively, associated with human adipose derived stem cells (hADSCs). On account soybean lecithin (SL) biosurfactants, sB7-PHA-NPs had a high encapsulation efficiency (>80%) BMPs...
In contrast to the early acting bone morphogenetic protein 2, 7 (BMP7) plays a decisive role mainly in late stages of formation. To overcome deactivation and degradation expensive BMP7, we designed novel long-acting BMP7 release system based on poly(3-hydroxybutyrate-co-4-hydroxybutyrate) (P34HB) nanoparticles enable induction osteogenic differentiation human adipose mesenchymal stem cells (ADSCs). order improve encapsulation efficiency avoid damage by organic solvents, was modified...