A5100603980- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Peripheral Artery Disease Management
- Neuroinflammation and Neurodegeneration Mechanisms
- Venous Thromboembolism Diagnosis and Management
- Atherosclerosis and Cardiovascular Diseases
- Diagnosis and Treatment of Venous Diseases
- Oral and Maxillofacial Pathology
- Lung Cancer Treatments and Mutations
- Cancer Genomics and Diagnostics
- SARS-CoV-2 and COVID-19 Research
- Immunodeficiency and Autoimmune Disorders
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Protease and Inhibitor Mechanisms
- Cardiac Structural Anomalies and Repair
- Neurological Disease Mechanisms and Treatments
- Radiomics and Machine Learning in Medical Imaging
- Peptidase Inhibition and Analysis
- COVID-19 Clinical Research Studies
- Immune cells in cancer
- Intracranial Aneurysms: Treatment and Complications
- Aortic aneurysm repair treatments
- Cerebrovascular and Carotid Artery Diseases
- Gold and Silver Nanoparticles Synthesis and Applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
Ningbo University
2025
Tianjin Huanhu Hospital
2025
Sun Yat-sen University
2025
Guiyang Medical University
2022-2024
Affiliated Hospital of Guizhou Medical University
2022-2024
Central South University
2021-2024
People's Liberation Army 401 Hospital
2022-2024
Shenzhen University
2024
Capital Medical University
2019-2024
Southwest Petroleum University
2024
Ischemic stroke (IS) is a detrimental neurological disease with limited treatments options. It has been challenging to define the roles of brain cell subsets in IS onset and progression due cellular heterogeneity CNS. Here, we employed single-cell RNA sequencing (scRNA-seq) comprehensively map populations mouse model MCAO (middle cerebral artery occlusion). We identified 17 principal clusters cell-type specific gene expression patterns as well subpopulations their functions various pathways....
Introduction: Leukocyte immunoglobulin-like receptor B4 (LILRB4) is a crucial regulator of immune responses, particularly within microglia, where it may influence the infiltration peripheral T cells into brain. However, specific role LILRB4 in modulating brain damage after acute ischemic stroke remains unclear. This study aims to investigate response and its potential protective effects against injury mice. Methods: Microglia-specific conditional knockout (LILRB4-KO) overexpression...
Leukocyte immunoglobulin-like receptor B4 (LILRB4) plays a significant role in regulating immune responses. LILRB4 microglia might influence the infiltration of peripheral T cells. However, whether and how expression aggravates brain damage after acute ischemic stroke remains unclear. This study investigates modulating response its potential protective effects against injury mice. Microglia-specific conditional knockout (LILRB4-KO) overexpression transgenic (LILRB4-TG) mice were constructed...
Introduction Rapid identification of infected individuals through viral RNA or antigen detection followed by effective personal isolation is usually the most way to prevent spread a newly emerging virus. Large-scale involves mass specimen collection and transportation. For biosafety reasons, denaturing transport medium has been extensively used during SARS-CoV-2 pandemic. However, high concentrations guanidinium isothiocyanate (GITC) in such media have raised issues around sufficient GITC...
Giant cell tumors of the spine have a high recurrence rate owing to their special anatomical site; hence, further treatment after is very challenging. Achieving effective tumor control and improving long-term quality life patients are main purposes consider for recurrent giant spine. A patient showing thoracic curettage received denosumab combined with precision radiotherapy, by which gained good control, could regain normal functioning. review relevant literature suggested that radiotherapy...
The new composite concrete with both lightweight, thermal insulation, heat insulation and light transmission properties is a type of building material energy saving consumption reduction functions. This paper integrates the research status scholars in this field at home abroad, realises lightweight blocks by studying aggregate porous concrete, selects suitable light- transmitting materials, tests transmittance mechanical after adding light-transmitting then analyzes advantages disadvantages...
At present, the treatment of recurrent pelvic osteosarcoma is too simple, and most patients are treated with chemotherapy, radiotherapy, and/or combined surgery. Here, we report a 29-year-old man diagnosed local osteosarcoma. Imaging showed that tumor had obvious enhancement abundant blood vessels. There was no indication After patient’s consent obtained, used anlotinib as sequential to chemotherapy. During first course adjuvant patient intensity-modulated radiotherapy (IMRT) total dose 60...
Atherosclerosis is a chronic lipid-driven inflammatory response of the innate and adaptive immune systems, it responsible for several cardiovascular ischemic events. The present study aimed to determine infiltration-related biomarkers in carotid atherosclerotic plaques (CAPs). Gene expression profiles CAPs were extracted from Expression Omnibus database. Differentially expressed genes (DEGs) between control groups screened by "limma" package R software. Immune cell infiltration was evaluated...
Objective To explore the value of 18 F-fluordeoxyglucose positron emission tomography/computed tomography ( F-FDG PET/CT) semi-quantitative parameters primary tumor combined with squamous cell carcinoma antigen (SCC-Ag) in predicting lymph node metastasis (LNM) cervical cancer (FIGO 2018 stage I-II). Materials and Methods A total 65 patients I-II underwent PET/CT were included our study. Comparing SCC-Ag between LNM group non-LNM group. Logistic regression receiver operating characteristic...
Skin wound caused by burns, disease, etc., is a substantial healthcare issue, it may result in infection and chronic state, long-term incidence even death. A highly effective viable therapy involved healing, this will present the more significant exploration. Marine bioactive peptides are currently being utilized due to their beneficial biological properties, which encompass anti-inflammatory, antioxidant, antimicrobial, anti-aging, antitumor activities, antihypertensive. These offer...
Pulmonary sarcomatoid carcinoma (PSC) is a rare subtype of non-small-cell lung cancer (NSCLC), which resistant to chemotherapy and radiotherapy with poor prognosis. PSC highly malignant prone recurrence even after surgery. The programmed death-ligand 1 (PD-L1) tumor cell proportion score (TPS) 5%, TERT TP53 gene mutations were detected in this patient accompanied by multiple metastatic sites. anlotinib novel multitarget tyrosine kinase inhibitor (TKI) that could be effective for advanced...
Abstract Background Patients with coronavirus disease 2019 have a high incidence of thrombosis that decreases after recovery. When is accompanied by diseases prone to thrombosis, risk post-infection thrombotic events may increase. Case presentation We report case digital ischemic gangrene in 24-year-old Chinese female systemic lupus erythematosus recovery from 2019. The pathogenesis was related clinical characteristics erythematosus, hypercoagulability caused 2019, and second-hit due viral...
To explore the associations between dietary zinc intake and cardiovascular diseases (CVDs), including congestive heart failure (CHF), coronary disease (CHD), angina, attack, cerebrovascular accident (CVA), this study was performed.
This study aimed to compare the efficacy of [
Denosumab has recently become an important part of the treatment regime for spinal giant cell tumors bone (GCTB). Its use significantly reduced risk surgery and postoperative complications in patients with GCTB. However, denosumab not yet been optimized to reap maximum benefits. Here, we have reported case a patient who was treated combination excision scraping GCTB T10 vertebrae, which achieved good tumor control no recurrence at 2-year follow-up. We also reviewed light relevant literature...