A5088638027- Mesenchymal stem cell research
- Autophagy in Disease and Therapy
- Acute Myeloid Leukemia Research
- Immune Response and Inflammation
- Protein Degradation and Inhibitors
- Immune cells in cancer
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Hemoglobinopathies and Related Disorders
- NF-κB Signaling Pathways
- Extracellular vesicles in disease
- Complement system in diseases
- Immunodeficiency and Autoimmune Disorders
- Renal Diseases and Glomerulopathies
- Pancreatic function and diabetes
- Lymphoma Diagnosis and Treatment
- Regional Development and Environment
- Neonatal Health and Biochemistry
- Medical Research and Treatments
- Erythrocyte Function and Pathophysiology
- Diet, Metabolism, and Disease
- Lipid metabolism and disorders
- CRISPR and Genetic Engineering
- Educational Reforms and Innovations
Southwest Petroleum University
2024
Southwest University
2023
Chinese PLA General Hospital
2020-2022
Chronic myelomonocytic leukemia (CMML) is a rare and heterogeneous hematological malignancy. It has been shown that the molecular abnormalities such as ASXL1, TET2, SETBP1, SRSF2 mutations are common in Caucasian population.We retrospectively analyzed 178 Chinese CMML patients. The targeted next generation sequencing (NGS) was used to evaluate 114 gene variations, prognostic factors for OS were determined by COX regression analysis.The patients showed unique mutational spectrum, including...
The new composite concrete with both lightweight, thermal insulation, heat insulation and light transmission properties is a type of building material energy saving consumption reduction functions. This paper integrates the research status scholars in this field at home abroad, realises lightweight blocks by studying aggregate porous concrete, selects suitable light- transmitting materials, tests transmittance mechanical after adding light-transmitting then analyzes advantages disadvantages...
Progressive β-cell dysfunction, a major characteristic of type 2 diabetes (T2D), is closely related to the infiltration inflammatory macrophages within islets. Mesenchymal stem cells (MSCs) have been identified alleviate dysfunction by modulating macrophage phenotype in T2D, but restoration β-cells single MSC infusion relatively transient. Decitabine (DAC) has reported polarize towards anti-inflammatory at low doses. We therefore investigated whether low-dose decitabine could enhance...
Abstract Introduction Paroxysmal Nocturnal Hemoglobinuria (PNH) is an acquired clonal disease of hematopoietic stem cells. It caused by somatic mutation the X‐linked PIGA gene, resulting in a deficient expression glycosylphosphatidylinositol‐anchored proteins (GPI‐APs). In this study, we aimed to explore diagnostic value next‐generation sequencing (NGS) and potential molecular basis PNH patients. Methods Genomic DNA 85 patients was analyzed 114‐gene NGS panel. Results Mutational analysis...
Objective To investigate whether umbilical cord mesenchymal stem cells (UC-MSCs) can exert kidney protection in diabetes rats through regulating autophagy. Methods Type 2 model was induced by a high-fat diet combined with low dosage of streptozotocin (STZ) intraperitoneal injection. After successful modeling,those were fed for another eight weeks,and the control group (10) given normal chow diet. The treatment (MSCs group, 10) infused UC-MSCs (3×106 suspended 0.5 ml PBS) via tail vein...
Abstract Background Diabetic nephropathy is closely related to immune-regulation, in which macrophages play a crucial role. In diabetic nephropathy, the classically activated (M1) increased while alternatively (M2) decreased kidney. Mesenchymal stem cells (MSCs) administration can alleviate however, mechanisms still remain unclear. MSCs have been shown stimulate from M1 phenotype M2 phenotype. Thus, we aimed investigate whether polarization of M1/M2 induced by was involved (DN). Methods our...