A5019781839- Wheat and Barley Genetics and Pathology
- Diagnosis and Treatment of Venous Diseases
- Corrosion Behavior and Inhibition
- Seed Germination and Physiology
- Kidney Stones and Urolithiasis Treatments
- Venous Thromboembolism Diagnosis and Management
- Mycotoxins in Agriculture and Food
- Genetics and Plant Breeding
- Plant Pathogens and Fungal Diseases
- Soybean genetics and cultivation
- Cancer-related molecular mechanisms research
- Genetic Mapping and Diversity in Plants and Animals
- CRISPR and Genetic Engineering
- Glycosylation and Glycoproteins Research
- Monoclonal and Polyclonal Antibodies Research
- Anodic Oxide Films and Nanostructures
- RNA modifications and cancer
- Peripheral Artery Disease Management
- Plant Genetic and Mutation Studies
- ZnO doping and properties
- Ferroptosis and cancer prognosis
- Pediatric Urology and Nephrology Studies
- Urinary Bladder and Prostate Research
- Plant pathogens and resistance mechanisms
- Chemokine receptors and signaling
Institute of Genetics and Developmental Biology
2020-2025
Chinese Academy of Sciences
2020-2025
Hebei University of Technology
2023-2024
Capital Medical University
2022-2024
Kowloon Hospital
2024
Faculty of 1000 (United States)
2024
New Jersey Department of Education
2024
Beijing Chao-Yang Hospital
2022-2023
Hainan Medical University
2023
Beijing Friendship Hospital
2022
Genetic improvement of grain yield is always an important objective in wheat breeding. Here, a genome-wide association study was conducted to parse the complex genetic composition yield-related traits 105 elite varieties (lines) using Wheat 90K Illumina iSelect SNP array. Nine traits, including maximum number shoots per square meter (MSN), effective spikes (ESN), percentage spike (PES), kernels (KPS), thousand-kernel weight (TKW), ratio kernel length/kernel width (RLW), leaf-area index...
Thousand-grain weight (TGW) of wheat (Triticum aestivum L.) contributes significantly to grain yield. In the present study, a candidate gene associated with TGW was identified through specific-locus amplified fragment sequencing (SLAF-seq) DNA bulks recombinant inbred lines (RIL) derived from cross between Jing 411 and Hongmangchun 21. The located on chromosome 7A, designated as TaTGW-7A complete genome sequence an open reading frame (ORF). A single nucleotide polymorphism (SNP) in first...
Chemokines serve important roles in the development of cancer. C-X3-C motif chemokine ligand 1 (CX3CL1) has been demonstrated to promote metastases different types tumors. The authors' previous studies that CX3CL1 (also termed fractalkine)/steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway is associated with spinal metastasis. In present study, it was observed CX3CL1/C-X3-C (CX3CR1) overexpressed prostate cancer tissues metastasis compared primary Overexpression...
Adenine base editors (ABEs) are novel genome-editing tools, and their activity has been greatly enhanced by eight additional mutations, thus named ABE8e. However, elevated catalytic was concomitant with frequent generation of bystander mutations. This effect precludes its safe applications required in human gene therapy. To develop next-generation ABEs that both catalytically efficient positionally precise, we performed combinatorial engineering NG-ABE8e. We identify a variant (NG-ABE9e),...
Cytokinin oxidase (CKX) plays a crucial role in plant growth and development by reversibly inactivating cytokinin (CTK). Twenty-four primer pairs, designed from ESTs of the TaCKX genes family common wheat, were used to identify their allelic variations associated with grain size, weight, filling rate 169 recombinant inbred lines (RIL) derived Jing 411 × Hongmangchun 21. TaCKX6a02, member gene family, amplified pair T31–32, showed close association traits this RIL population. Statistical...
Seed dormancy and germination are important agronomic traits in wheat (Triticum aestivum L.) because they determine pre-harvest sprouting (PHS) resistance thus affect grain production. These processes regulated by Gibberellic Acid-Stimulated Regulator (GASR) genes. In this study, we identified 37 GASR genes common wheat, which were designated TaGASR1-37. Moreover, 40 pairs of paralogous genes, only one had a Ka/Ks value greater than 1, indicating that most TaGASR have undergone negative...
Spinal metastasis occurs in 50‑75% of bone metastases caused by hepatocellular carcinoma (HCC), and HCC‑derived spinal can lead to a less favorable prognosis. Recently, several studies have demonstrated that C‑X3‑C motif chemokine ligand 1 (CX3CL1) is closely associated with cancer metastasis, its secretion modulated disintegrin metalloproteinase 17 (ADAM17). Bone marrow endothelial cells (BMECs) are an essential component marrow. However, little known about the roles effects BMECs on HCC...
Only B lymphocytes can express immunoglobulins according to the traditional immunological theories, and expression of immunoglobulin G (IgG) messenger RNA (mRNA) protein was found in certain human cancer cells recently. However, pattern IgG its possible role urothelial carcinoma are still elusive. In this study, we investigated two cell lines, T24 BIU-87, 56 cases clinical tissues. The mRNA positively detected by situ hybridization reverse transcription PCR; furthermore, also...
The etiology and pathogenesis of bladder cancer (BCa) is complex. MicroRNA (miRNA) has been implicated in BCa. Targeting signal transducer activator transcription 3 (STAT3) by miR‑124 to regulate tumorigenesis demonstrated other types cancer. In the present study, levels were downregulated BCa T24 cell line STAT3 was increased lines. Transfection mimics into cells significantly inhibited expression. A luciferase assay confirmed that directly targeted 3'untranslated region inhibit STAT...
Abstract To assess the safety and efficacy of endovascular embolization techniques, we compared short- to medium-term prognosis coil for symptomatic visceral aneurysms (SVAA) asymptomatic (ASVAA) identify risk factors associated with 30-day mortality. Explore symptom profile intrinsic associations SVAA. A retrospective study 66 consecutive patients at two tertiary care hospitals from 2010 2020 mid-term outcomes 22 VAAs 44 treated embolization. Univariate log-rank tests were used analyze...
Wheat, one of the world's major crops, is seriously affected by fungal diseases, especially in regions with high moisture and moderately warm temperatures. This paper reviews various molecular conventional techniques that are used to identify genotypes resistance alleles associated Fusarium head blight (FHB) diseases. Quantitative trait loci (QTL) type II, designated as Fhb1, frequently applied plant breeding, newly recognized genes related this disease give extra insights into...
Atherosclerosis is a chronic lipid-driven inflammatory response of the innate and adaptive immune systems, it responsible for several cardiovascular ischemic events. The present study aimed to determine infiltration-related biomarkers in carotid atherosclerotic plaques (CAPs). Gene expression profiles CAPs were extracted from Expression Omnibus database. Differentially expressed genes (DEGs) between control groups screened by "limma" package R software. Immune cell infiltration was evaluated...