A5020151036- Genetic Mapping and Diversity in Plants and Animals
- Evolution and Genetic Dynamics
- Plant Molecular Biology Research
- Genetic and phenotypic traits in livestock
- Bioinformatics and Genomic Networks
- Chromosomal and Genetic Variations
- Chemokine receptors and signaling
- Genetics and Plant Breeding
- Gut microbiota and health
- Genetic diversity and population structure
- Plant Reproductive Biology
- Spinal Fractures and Fixation Techniques
- Plant Gene Expression Analysis
- Management of metastatic bone disease
- Cytokine Signaling Pathways and Interactions
- Plant and animal studies
- Evolutionary Game Theory and Cooperation
- Gene Regulatory Network Analysis
- Bacterial Genetics and Biotechnology
- Fungal Plant Pathogen Control
- Spine and Intervertebral Disc Pathology
- Plant-Microbe Interactions and Immunity
- Genomics and Phylogenetic Studies
- Single-cell and spatial transcriptomics
- Bone and Joint Diseases
Gansu Agricultural University
2025
Shandong University of Technology
2021-2025
Qiqihar Medical University
2016-2025
The First Affiliated Hospital, Sun Yat-sen University
2014-2024
Zhongshan Hospital
2014-2024
Fudan University
2014-2024
Sun Yat-sen University
2014-2024
Animal Welfare Institute
2024
Beijing Forestry University
2014-2023
Beijing Advanced Sciences and Innovation Center
2021
Mei (Prunus mume) is an ornamental woody plant that has been domesticated in East Asia for thousands of years. High diversity floral traits, along with its recent genome sequence, makes mei ideal model system studying the evolution plants. Here, we investigate genetic architecture traits and domestication history by sampling resequencing a total 351 samples including 348 accessions three other Prunus species at average sequencing depth 19.3×. Highly-admixed population structure introgression...
YT521-B homology (YTH) domain-containing RNA-binding proteins (YTPs) are important N6-methyladenosine (m6A) readers that have crucial roles in determining the destiny of m6A-modified RNAs, which most widespread RNA modifications eukaryotes. Tomatoes (Solanum lycopersicum L.) hold significant importance both dietary consumption patterns and scientific inquiries. While YTP gene family has been characterized tomatoes, their specific reactions to low temperature waterlogging stresses remain be...
Abstract Background Compared with other Populus species, euphratica Oliv. exhibits better tolerance to abiotic stress, especially those involving extreme temperatures. However, little is known about gene regulation and signaling pathways involved in low temperature stress responses this species. Recent development of Illumina/Solexa-based deep-sequencing technologies has accelerated the study global transcription profiling under specific conditions. To understand network controlling...
Chemokines serve important roles in the development of cancer. C-X3-C motif chemokine ligand 1 (CX3CL1) has been demonstrated to promote metastases different types tumors. The authors' previous studies that CX3CL1 (also termed fractalkine)/steroid receptor coactivator (Src)/focal adhesion kinase (FAK) signaling pathway is associated with spinal metastasis. In present study, it was observed CX3CL1/C-X3-C (CX3CR1) overexpressed prostate cancer tissues metastasis compared primary Overexpression...
C-X3-C chemokine ligand 1 (CX3CL1) has been shown to be involved in the development of multiple tumors. Our previous study demonstrated that CX3CL1 may process metastasis various malignant tumors spine, including breast cancer, but molecular mechanism was still unknown. In present study, we found receptor CX3CR1 overexpressed spinal metastases cancer than para-tumor tissue. terms CX3CL1, it significantly more expressed normal cancellous bone limbs. However, not at a high level every cell...
As a plant-specific transcription factor, the NAC (NAM, ATAF1/2 and CUC2) domain protein plays an important role in plant growth development, as well stress resistance. Based on genomic data of cacao tree, this study identified 102 genes named them according to their location within genome. The phylogeny sequence tree family was analyzed using various bioinformatic methods, then divided into 12 subfamilies. Then, amino-acid composition, physicochemical properties, location, gene structure,...
The cervical sagittal parameters of the normal population and impact disc degeneration on alignment have not been clearly defined yet. This study is applied to investigate characteristics relationships in adults patients with degeneration. We reviewed 50 control subjects (normal group, NG) (degeneration DG), who had both MRI radiographs obtained together, between January 2010 September 2015. Data including C2–7 lordosis (CL), T1 slope (T1S), thoracic inlet angle (TIA), neck tilt (NT),...
Volatile organic compounds (VOCs) play key roles in plant–plant communication, especially under attack by pests. E-2-hexenal is an important component of VOCs, and whether it can induce endogenous insect resistance plants not clear. Here, we show that activates early signaling events Arabidopsis (Arabidopsis thaliana) mesophyll cells, including H2O2 burst at the plasma membrane, directed flow calcium ions, increase cytosolic concentration. Treatment wild-type with increases their when...
Increased use of vancomycin has led to the emergence vancomycin-intermediate Staphylococcus aureus (VISA). To investigate mechanism VISA development, 39 methicillin-susceptible strains and 3 MRSA were treated with induce non-susceptibility, mutations in six genes analyzed. All vitro for 60 days. MICs determined by agar dilution E-test methods. Vancomycin was then removed assess stability mutations. Following days treatment vitro, 29/42 generated. The complete sequences rpoB, vraS, graR,...
Spinal metastasis occurs in 50‑75% of bone metastases caused by hepatocellular carcinoma (HCC), and HCC‑derived spinal can lead to a less favorable prognosis. Recently, several studies have demonstrated that C‑X3‑C motif chemokine ligand 1 (CX3CL1) is closely associated with cancer metastasis, its secretion modulated disintegrin metalloproteinase 17 (ADAM17). Bone marrow endothelial cells (BMECs) are an essential component marrow. However, little known about the roles effects BMECs on HCC...
Abstract Understanding how plants interact with their colonizing microbiota to determine plant phenotypes is a fundamental question in modern science. Existing approaches for genome-wide association studies (GWAS) are often focused on the analysis between host genes and abundance of individual microbes, failing characterize genetic bases microbial interactions that thought be important structure, organization, function. Here, we implement behavioral model quantify various patterns...
The bottle gourd (Lagenaria siceraria, Cucurbitaceae) is an important horticultural crop exhibiting tremendous diversity in fruit shape. genetic architecture of shape variation this species remains unknown. We assembled a long-read-based, high-quality reference genome (ZAAS_Lsic_2.0) with contig N50 value over 390-fold greater than the existing genomes. then focused on dissection using one-step geometric morphometrics-based functional mapping approach. identified 11 quantitative trait loci...
Gene regulatory networks (GRNs) have been widely used as a fundamental tool to reveal the genomic mechanisms that underlie individual's response environmental and developmental cues. Standard approaches infer GRNs holistic graphs of gene co-expression, but such cannot quantify how gene-gene interactions vary among individuals they alter structurally across spatiotemporal gradients. Here, we develop general framework for inferring informative, dynamic, omnidirectional, personalized...
How genes interact with the environment to shape phenotypic variation and evolution is a fundamental question intriguing biologists from various fields. Existing linear models built on single are inadequate reveal complexity of genotype-environment (G-E) interactions. Here, we develop conceptual model for mechanistically dissecting G-E interplay by integrating previously disconnected theories methods. Under this integration, evolutionary game theory, developmental modularity variable...
The aroma, taste, and flavour profiles of mango cultivars vary, directly influencing their marketability consumer acceptance. In this study, we explored the effects volatile organic compounds (VOCs) on distinct aromas two during storage using GC-IMS HS-SPME-GC-MS combined with OPLS-DA analysis. Our findings revealed that terpene aldehyde contents were higher in 'Tainong' cultivar, compared to 'Hongyu' mango, while ester content was lower. aroma attributed presence terpinolene, 2-nonenal,...
Rationale: The spine is one of the most common metastatic sites non-small cell lung cancer (NSCLC), and NSCLC spinal metastasis results in serious consequences. Metastatic extravasation disseminated cells including increased invasiveness, adhesion transendothelial migration crucial for tumor metastasis. This study aimed to investigate mechanisms underlying based on C-X3-C motif chemokine ligand 1- (CX3CL1) intercellular molecule-1- (ICAM-1) mediated signaling network. Methods:...