A5014390894- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Nanoparticle-Based Drug Delivery
- Photodynamic Therapy Research Studies
- Tryptophan and brain disorders
- Cell death mechanisms and regulation
- Immunotherapy and Immune Responses
- Inflammasome and immune disorders
- Stress Responses and Cortisol
- Advanced biosensing and bioanalysis techniques
- Drug Transport and Resistance Mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Parallel Computing and Optimization Techniques
- Dermatologic Treatments and Research
- Traditional Chinese Medicine Analysis
- Genetic Syndromes and Imprinting
- Ginkgo biloba and Cashew Applications
- Advancements in Transdermal Drug Delivery
- Drug Solubulity and Delivery Systems
- Dendrimers and Hyperbranched Polymers
- Graphene and Nanomaterials Applications
- Ion Transport and Channel Regulation
- Hydrogels: synthesis, properties, applications
- Wound Healing and Treatments
- Ginseng Biological Effects and Applications
Tongren Hospital
2018-2023
Shanghai Jiao Tong University
2018-2023
Tsinghua–Berkeley Shenzhen Institute
2023
Tsinghua University
2023
China Pharmaceutical University
2018-2023
University Town of Shenzhen
2023
Minzu University of China
2023
State Ethnic Affairs Commission
2023
Xizang Minzu University
2021
Indiana University School of Medicine
2020
Abstract Although multiple hypotheses had been proposed to clarify the causes of depression, accurate pathogenesis and effective treatment depression still need be solved. Pathological change astrocytes has recognized play a pivotal role in depression. Fluoxetine is first selective serotonin reuptake inhibitor, however, underlying mechanisms fluoxetine are incompletely excavated. Emerging evidence shows that promotes autophagic processes tumor cells. However, whether astrocytic autophagy...
The low efficiency of photodynamic therapy (PDT) is caused by tumor hypoxia and the adaptive immune resistance/evasion cells, while currently emerging checkpoint restores intrinsic capacities but can't directly attack cells. Methods: Herein we report an integrated nanoplatform that combines PDT with immunotherapy to enhance therapeutic effects simultaneously inhibit cells resistance/evasion. To achieve this, fabricated Mn@CaCO3/ICG nanoparticles loaded them PD-L1-targeting siRNA. Results:...
Emerging evidence indicates that NLRP3 inflammasome-induced inflammation plays a crucial role in the pathogenesis of depression. Thus, inhibition inflammasome activation may offer therapeutic benefit treatment Fluoxetine, widely used antidepressant, has been shown to have potential antiinflammatory activity, but underlying mechanisms remain obscure.We chronic mild stress model and cultured primary macrophage/microglia investigate effects fluoxetine on its mechanisms.We demonstrated...
Summary Aim Ginkgolide B (GB) has shown neuroprotective effect in treating ischemic stroke, related to its property of anti‐inflammation. Nevertheless, it is unclear whether GB able modulate microglia/macrophage polarization, which recently been proven be vital the pathology stroke. Methods We performed transient middle cerebral artery occlusion (tMCAO) on C57BL/6J male mice and induced cultured BV2 microglia primary bone marrow‐derived macrophages M1/2 phenotype by LPS+ interferon‐γ IL‐4,...
Development of safe, efficient nanocomplex for targeted imaging and therapy cancer stem cells in brain glioma has become a great challenge. Herein, low-density lipoprotein receptor-related protein RNA aptamer bound CD133 were used as dual-targeting ligands to prepare dual-modified cationic liposomes (DP-CLPs) loaded with survivin siRNA paclitaxel (DP-CLPs-PTX-siRNA) actively targeting treating CD133+ after passing through the blood-brain barrier. After being administrated DP-CLPs-PTX-siRNA...
Objective: To construct a novel nanoplatform GNS@CaCO3/Ce6-NK by loading the CaCO3-coated gold nanostars (GNSs) withChlorin e6 molecules (Ce6) into human peripheral blood mononuclear cells (PBMCs)-derived NK for tumor targetedtherapy. Methods: GNS@CaCO3/Ce6 nanoparticles were prepared and characterized TEM UV-vis. The cell surface markers andcytokines secretion of before after detected Flow Cytometry(FCM) ELISA. Effects on A549 cancer was determined FCM CCK-8.Intracellular fluorescent...
An effective accumulation of the photosensitive drugs in target tissues is a vital prerequisite for obtaining optimal photodynamic or photothermal treatment effects during lung cancer treatment. In this study, porous Fe3O4 nanoparticles were used to efficiently load near-infrared drug indocyanine green (ICG) pores (denoted as Fe/ICG) by electrostatic adsorption. Subsequently, Fe/ICG was modified with hyaluronic acid (HA) construct novel nanoprobe Fe/ICG@HA). Fe/ICG@HA exhibited not only...
This study aimed to investigate whether the anti-tumor effect of gemcitabine (GEM) in non-small-cell lung cancer (NSCLC) treatment was affected by Danggui Buxue decoction (DBD), and explore potential mechanisms. The combined use GEM DBD showed an enhanced tumor growth inhibition a murine Lewis carcinoma (LLC) model. LC-MS/MS results that pharmacokinetic behaviors active metabolite, triphosphate (dFdCTP), were found be altered remarkably peripheral blood mononuclear cells (PBMC)...
U87-derived stem-like cells (U87-SLCs) were cultured using serum-free stem cell media and identified by both biological behaviors markers. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) paclitaxel (PX), in combination or alone, was used to treat U87-MG human glioma (U87 cells) U87-SLCs. The results showed that TRAIL/PX cannot only synergistically inhibit U87 but also We observed a significantly higher apoptotic rate simultaneously treated with for 24 h compared either...
Current formulation development strongly relies on trial-and-error experiments in the laboratory by pharmaceutical scientists, which is time-consuming, high cost and waste materials. This research aims to integrate various computational tools, including machine learning, molecular dynamic simulation physiologically based absorption modeling (PBAM), enhance andrographolide (AG) /cyclodextrins (CDs) design. The lightGBM prediction model we built before was utilized predict AG/CDs inclusion's...
HA/ES-ALA transdermal nanogels improves ALA utilization and enhances photodynamic therapy by its synergistic effect.
The therapeutic outcome of chemotherapy is limited, although it still the preferent strategy for cancer therapy. By regulation tumor microenvironment and introduction another manner combination therapy can enhance anticancer activity chemotherapeutics. Herein, we have constructed a hybrid nanostructure which composed manganese dioxide (MnO2) doxorubicin (DOX) as well IR780 by stabilizing with BSA (BMDI) in one-pot procedure to alleviate hypoxia growth inhibition. MnO2 react H2O2 generate...
'Secondary insult' following primary traumatic brain injury (TBI), including ischemia and edema, may aggravate impairments affect the outcomes. The hippocampus is particularly sensitive to or edema due its selective vulnerability, as neural cells of be more prone abnormal function cell death in response edema. Aquaporin‑1 (AQP‑1) was reported associated with cerebral edema; however, expression role AQP‑1 hippocampal TBI have seldom been investigated. In current study, BALB/c mouse closed...
Hypertrophic scar (HS), which results from prolonged inflammation and excessive fibrosis in re-epithelialized wounds, is one of the most common clinical challenges. Consequently, sophisticated transdermal transfersome nanogels (TA/Fu-TS) are prepared to control HS formation by synergistically inhibiting suppressing fibrosis. TA/Fu-TSs have unique structures comprising hydrophobic triamcinolone acetonide (TA) lipid multilayers hydrophilic 5-fluorouracil aqueous cores, perform satisfactorily...
In the present study, The PEI/DNA (PD) complexes was first prepared with positive surface charge under a suitable N/P ratio of 10. redundant partially and excessively shielded by polysaccharide, hyaluronic acid (HA), in aqueous solution. HA/PEI/DNA ternary were characterized assessing zeta potential size, then transferred to MDA-MB-435, MDA-MB-231, MCF-7 cell lines different amounts HA-specific CD44 receptors on surface. Consequently, transfection efficiency all show little increased (low...