A5103013268- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Photodynamic Therapy Research Studies
- RNA Interference and Gene Delivery
- Electrospun Nanofibers in Biomedical Applications
- Graphene and Nanomaterials Applications
- Cancer, Hypoxia, and Metabolism
- Cell Adhesion Molecules Research
- Blood properties and coagulation
- Textile materials and evaluations
- Childhood Cancer Survivors' Quality of Life
- Ginseng Biological Effects and Applications
- Pharmacological Effects of Natural Compounds
- Hematopoietic Stem Cell Transplantation
- Lung Cancer Research Studies
- Abdominal Surgery and Complications
- Neutropenia and Cancer Infections
- Phytochemistry and biological activity of medicinal plants
- Intestinal Malrotation and Obstruction Disorders
- Tryptophan and brain disorders
- Immunotherapy and Immune Responses
- Vibration and Dynamic Analysis
- Intestinal and Peritoneal Adhesions
- Cancer, Stress, Anesthesia, and Immune Response
- CAR-T cell therapy research
Tongji Hospital
2024
Union Hospital
2024
Union Hospital
2010-2024
Huazhong University of Science and Technology
2010-2024
Hubei Cancer Hospital
2024
Sichuan University
2019-2022
Chengdu University
2019-2021
Jiangnan University
2013
Ministry of Education of the People's Republic of China
2010
Nanoparticle-based drug delivery faces challenges from the imprecise targeted and low bioavailability of drugs due to complex biological barriers. Here, we designed cascade-targeting, dual drug-loaded, core-shell nanoparticles (DLTPT) consisting CD44-targeting hyaluronic acid shells decorated with doxorubicin (HA-DOX) mitochondria-targeting triphenylphosphonium derivative nanoparticle cores loaded lonidamine (LND) dimers (LTPT). DLTPT displayed prolonged blood circulation time efficiently...
Abstract Reactive oxygen species (ROS)‐activated immunotherapy is decided by the ROS level and immunosuppressive microenvironment. This report shows construction of indoleamine 2,3‐dioxygenase (IDO) inhibitor dimers (d‐ss‐DO)‐loaded polymer nanoparticles assembled from Ce6‐tethered disulfide bond‐bridged copolymers. The biomimetic polymeric can serve as glutathione peroxidase to deplete (GSH) realize dense‐to‐loose structure inversion (SI) arising GSH‐triggered bonds breakage, which favors...
Inflammatory bowel disease (IBD), including Crohn's and ulcerative colitis (UC), is a chronic characterized by diffuse mucosal inflammation limited to the colon. Topical drug delivery systems that could be facilely performed efficiently retained at colon sites are attractive for clinical IBD treatment. Herein, we report exploration of an injectable thermosensitive copolymer hydrogel as topical formulation treatment demonstrate its feasibility in UC shielding ulcer from external environment...
Effective delivery of nanomedicines to tumor tissues depends on both the microenvironment and nanomedicine properties. Accordingly, modification or advanced design was emerging improve tumors. However, few studies have emphasized necessity optimize properties simultaneously treatment. In present study, imatinib mesylate (IMA) used normalize including platelet-derived growth factor receptor-β expression inhibition, vessel normalization, perfusion improvement as demonstrated by...
An all in one nano-system with active-targeting, enzyme-triggered deshielding and positive-charge characteristics was fabricated for chemo/photo-combination therapy to allow efficient tumor targeting, cellular internalization lysosomal escape. The of NPs induced by enzyme triggered degradation the NP shell, consequently exposure positively charged core accelerates escape from lysosome exert anticancer effects high efficiency.
Nanoparticles with active-targeting, enzyme and ROS sensitive features were fabricated to load AFT for molecular targeted- photodynamic combinational therapy.
Effective EPR and tumor penetration are bottlenecks in current nanomedicine therapy. Comosol software was utilized to analyze the motion process of nanoparticles (NPs) with different shapes, from blood vessels tissue, address this. By calculation, urchin-like NPs experienced higher drag forces than spherical NPs, facilitating their effects. Thus, indocyanine green-loaded hydroxyethyl starch-cholesterol (ICG@HES-CH) were prepared by leveraging instability ICG responding near-infrared light...
Unsatisfactory drug loading capability, potential toxicity of the inert carrier and limited therapeutic effect a single chemotherapy are all vital inhibitory factors carrier-assisted delivery systems for chemotherapy. To address above obstacles, series carrier-free nanoplatforms self-assembled by dual-drug conjugates was constructed to reinforce against tumors simultaneously disrupting intratumoral DNA activity inhibiting mitochondria function. In this nanoplatform, mitochondria-targeting...
Abstract Challenges associated with low-drug-loading capacity, lack of active targeting tumor cells and unspecific drug release nanocarriers synchronously plague the success cancer therapy. Herein, we constructed active-targeting, redox-activated polymeric micelles (HPGssML) self-assembled aptamer-decorated, amphiphilic biodegradable poly (benzyl malolactonate-co-ε-caprolactone) copolymer disulfide linkage π-conjugated moieties. HPGssML a homogenous spherical shape nanosized diameter (∼150...
Platelets play important roles in several physiological and pathological processes. Multiple antiplatelet drugs have been developed for clinical practice. The active components of traditional Chinese medicine with antithrombotic effects are promising to modulate platelet function. In our study, the effect isoliquiritigenin (ILTG) its mechanisms were examined.Human platelet-rich plasma a washed suspension prepared. stimulated using collagen, thrombin, or adenosine diphosphate (ADP)....
Dynamical mathematical model was established for accurately positioning, fast response and real-time tracing of electro-hydraulic servo control system in railway vehicle bogie parameters test with elastic load. The could precisely the output position force hydraulic cylinders. Induction methods proposed paper. simulation verified by software simulink. Meanwhile key factors affecting dynamical characteristics were discussed detail. Through results, high precision is obtained application need...
Background: Uncontrolled inflammation is a pathological state that underlies many diseases. Despite the development of numerous anti-inflammatory agents, treatment uncontrolled remains challenging task. The lack drug selectivity and specificity, limited tissue penetration, poor pharmacokinetic properties contribute to low efficacy high toxicity current therapies.Methods: We developed dual-targeting delivery system for [5-(p-fluorophenyl)-2-ureido]thiophene-3-carboxamide (TPCA-1), potent...