A5101860969- Nanoparticle-Based Drug Delivery
- Crystallization and Solubility Studies
- Nanoplatforms for cancer theranostics
- Alzheimer's disease research and treatments
- Neuroinflammation and Neurodegeneration Mechanisms
- Polyoxometalates: Synthesis and Applications
- X-ray Diffraction in Crystallography
- Surfactants and Colloidal Systems
- Supramolecular Self-Assembly in Materials
- Advanced biosensing and bioanalysis techniques
- RNA Interference and Gene Delivery
- Electrocatalysts for Energy Conversion
- Pain Mechanisms and Treatments
- Minerals Flotation and Separation Techniques
- Metal-Organic Frameworks: Synthesis and Applications
- Pickering emulsions and particle stabilization
- Proteins in Food Systems
- Advanced Drug Delivery Systems
- Immunotherapy and Immune Responses
- Catalytic Processes in Materials Science
- Aluminum toxicity and tolerance in plants and animals
- Curcumin's Biomedical Applications
- Efficiency Analysis Using DEA
- Stress Responses and Cortisol
- Epigenetics and DNA Methylation
Sichuan University
2018-2025
Fudan University
2024
Shandong University
2024
Guizhou University
2024
Shanghai Medical College of Fudan University
2024
State Key Laboratory of Medical Neurobiology
2024
Northeast Agricultural University
2023
Jilin University
2019-2022
Shenyang Pharmaceutical University
2020-2022
Shenzhen Institute of Information Technology
2022
Nanoparticle-based drug delivery faces challenges from the imprecise targeted and low bioavailability of drugs due to complex biological barriers. Here, we designed cascade-targeting, dual drug-loaded, core-shell nanoparticles (DLTPT) consisting CD44-targeting hyaluronic acid shells decorated with doxorubicin (HA-DOX) mitochondria-targeting triphenylphosphonium derivative nanoparticle cores loaded lonidamine (LND) dimers (LTPT). DLTPT displayed prolonged blood circulation time efficiently...
Abstract Alzheimer's disease (AD), as a progressive and irreversible brain disorder, remains the most universal neurodegenerative disease. No effective therapeutic methods are established yet due to hindrance of blood‐brain barrier (BBB) complex pathological condition AD. Therefore, multifunctional nanocarrier (Rapa@DAK/siRNA) for AD treatment is constructed achieve small interfering RNA β‐site precursor protein (APP) cleaving enzyme‐1 (BACE1 siRNA) rapamycin co‐delivery into brain, based on...
Inflammatory responses, manifested in excessive oxidative stress and microglia overactivation, together with metal ion-triggered amyloid-beta (Aβ) deposition, are critical hallmarks of Alzheimer’s disease (AD). The intricate pathogenesis causes severe impairment neurons, which, turn, exacerbates Aβ aggregation facilitates AD progression. Herein, multifunctional melanin-like ion chelators neuroinflammation regulators (named PDA@K) were constructed for targeted treatment AD. In this platform,...
A brain-targeting nanodelivery system has been a hot topic and undergone rapid progression. However, due to various obstacles such as the intestinal epithelial barrier (IEB) blood-brain (BBB), few nanocarriers can achieve through oral administration. Herein, an intelligent nanoparticle (FTY@Man NP) constructed from PLGA-PEG skeleton loaded with fingolimod (FTY) externally modified mannose was designed in combination glucose control strategy for multitarget treatment of Alzheimer's disease...
Limited tumor targeting and poor penetration of nanoparticles are two major obstacles to improving the outcome therapy. Herein, coadministration tumor-homing peptide iRGD multistage-responsive penetrating for treatment breast cancer reported. This nanoparticle, IDDHN, was comprised an NO donor-modified hyaluronic acid (HN) shell a small-sized dendrimer, namely, dendri-graft-l-lysine conjugated with doxorubicin indocyanine (IDD). The results showed that IDDHN could be degraded rapidly from...
Abstract The application of combinational therapy makes up for the limitation monotherapy and achieves superior treatment against cancer. However, remains restricted by poor tumor‐specific delivery abscopal effect. Herein, reactive oxygen species (ROS)‐responsive PEGylated bilirubin nanoparticles (BRNPs) are developed to encapsulate two glutathione‐activatable drugs, including dimer‐7‐ethyl‐10‐hydroxycamptothecin (d‐SN38) dimer‐lonidamine (d‐LND). Dimerization drugs significantly increases...
The encapsulation of polyoxomolybdic cobalt (CoPMA) and acid (PMA) within the Zr-based metal–organic frameworks (Zr-MOFs) UiO-bpy (connected by 2,2′-bipyridine-5,5′-dicarboxylic linkers) UiO-67 4,4′-biphenyldicarboxylic has been achieved direct solvothermal synthesis. Relatively high content polyoxometalate (POM) clusters (ranging from 12 to 15 wt % loading) could be introduced cages Zr-MOFs form uniform hybrid composites POM@Zr-MOFs. catalytic properties these were investigated for olefins...
The neurovascular unit (NVU) is highly responsible for cerebral homeostasis and its dysfunction emerges as a critical contributor to Alzheimer's disease (AD) pathology. Hence, rescuing NVU might be viable approach AD treatments. Here, we fabricated self-regulated muti-functional nano-modulator (siR/PIO@RP) that can intelligently navigate damaged blood-brain barrier release therapeutical cargoes synergetic therapy. resulting siR/PIO@RP enables self-regulation of distribution in accordance...
In order to better evaluate the transport effect of nanoparticles through nasal mucosa, an in vitro cavity-mimic model was designed based on M cells. The differentiation cells induced by co-culture Calu-3 and Raji invert model. ZO-1 protein staining fluorescein sodium dexamethasone showed that inverted formed a dense monolayer possessed ability. observed up-regulated expression Sialyl Lewis A antigen (SLAA) integrin β1, down-regulated activity alkaline phosphatase. After targeting with iRGD...
The gel properties of sodium alginate (SA) have been revealed to be strongly correlated with its ratio D-mannuronate L-guluronate (M/G ratio). Herein, we focused on SA different M/G ratios conduct an in-depth study the effect difference physicochemical stability and calcium release behavior Pickering emulsion stabilized by carbonate (CaCO3). oil phase was added aqueous phase, prepared (2.23, 0.89, 0.56) CaCO3, for one-step shearing obtain E1, E2, E3 emulsions, respectively. results particle...
The functional and optimal design of optical metasurfaces poses great challenges, particularly in situations requiring multifunctionalities. conventional forward relies on a priori knowledge, which limits the development with customized functions. Inverse has achieved major breakthroughs developing new functionalities but been hindered by inevitably invoking full-wave electromagnetic solver, subjected to low efficiency, slow convergence, being hard implement. Here, we propose general...
This study investigates the catalytic and allosteric roles of a flexible loop in tryptophan synthase alpha 2 beta complex. connects helix 6 strand subunit, an 8-fold alpha/beta barrel polypeptide. We have engineered three mutations this disordered loop: deletion residues 185-187 replacement threonine 183 by serine (T183S) or alanine (T183A). Position is site inactivating mutation identified Yanofsky's group (Yanofsky, C., Drapeau, G. R., Guest, J. Carlton, B. C. (1967) Proc. Natl. Acad. Sci....