A5102986738- Tryptophan and brain disorders
- Lung Cancer Treatments and Mutations
- Cancer-related molecular mechanisms research
- Inflammasome and immune disorders
- Cancer-related Molecular Pathways
- Lung Cancer Research Studies
- Stress Responses and Cortisol
- RNA Research and Splicing
- Neuroinflammation and Neurodegeneration Mechanisms
- Wnt/β-catenin signaling in development and cancer
- Autophagy in Disease and Therapy
- Drug Transport and Resistance Mechanisms
- MicroRNA in disease regulation
- HER2/EGFR in Cancer Research
- Cytokine Signaling Pathways and Interactions
- Cancer therapeutics and mechanisms
- RNA modifications and cancer
- Functional Brain Connectivity Studies
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Autoimmune and Inflammatory Disorders Research
- Tissue Engineering and Regenerative Medicine
- Cancer Mechanisms and Therapy
- Adenosine and Purinergic Signaling
- Spine and Intervertebral Disc Pathology
Bengbu Medical College
2015-2024
Shanghai Eighth People Hospital
2021-2024
Chengdu Medical College
2021-2024
Tianjin University of Traditional Chinese Medicine
2024
First Affiliated Hospital of Bengbu Medical College
2020-2024
Zhejiang Chinese Medical University
2009-2024
Harbin Institute of Technology
2024
Shanghai Institute of Materia Medica
2016-2023
Chinese Academy of Sciences
2007-2023
Heilongjiang Academy of Forestry
2023
Aging-related, nonresolving inflammation in both the central nervous system (CNS) and periphery predisposes individuals to development of neurodegenerative disorders (NDDs). Inflammasomes are thought be especially relevant immune homeostasis, their dysregulation contributes NDDs. However, few agents have been clinically shown reduce NDD incidence by targeting inflammasomes. Our study indicated that NLRP3 (NLR family, pyrin domain containing 3) inflammasome is involved Parkinson disease (PD)...
Emerging evidence suggests that astrocyte loss is one of the most important pathological features in hippocampus patients with major depressive disorder (MDD) and mice. Pyroptosis a recently discovered form programmed cell death depending on Caspase–gasdermin D (Casp-GSDMD), which involved multiple neuropsychiatric diseases. However, involvement pyroptosis onset MDD glial injury remains obscure. Here, we observed mice showed astrocytic pyroptosis, was responsible for loss, selective...
Abstract Although multiple hypotheses had been proposed to clarify the causes of depression, accurate pathogenesis and effective treatment depression still need be solved. Pathological change astrocytes has recognized play a pivotal role in depression. Fluoxetine is first selective serotonin reuptake inhibitor, however, underlying mechanisms fluoxetine are incompletely excavated. Emerging evidence shows that promotes autophagic processes tumor cells. However, whether astrocytic autophagy...
The function and regulation of different heterogeneous reactive states astrocytes in depression remain unclear. Here, we demonstrate that neurotoxic (A1-like) are strongly induced, prior to behavioral impairments dendritic atrophy, depression-like mice. More interestingly, global or microglia-specific knockout Nod-like receptor protein 3 (Nlrp3) markedly mitigates A1-like astrocyte induction, whereas astrocyte-specific Nlrp3 depletion is ineffective. Microglial ablation also alleviates the...
Non-small cell lung cancer (NSCLC) patients with activating EGFR mutations initially respond to first-generation inhibitors; however, the efficacy of these drugs is limited by acquired resistance driven T790M mutation. The discovery third-generation inhibitors overcoming and their new mechanisms have attracted much attention.We examined antitumor activities potential mechanism a novel inhibitor in vitro vivo using ELISA, SRB assay, immunoblotting, flow cytometric analysis, kinase array,...
Increased kynurenine (Kyn) metabolized from tryptophan (Try) is a biomarker in the immune dysfunction of depression. However, mechanism by which Kyn change promotes depression poorly defined. Astrocytes are involved neuroinflammation Among numerous inflammatory cytokines, interleukin-1β (IL-1β) produced astrocytic Nod-like receptor protein (NLRP) inflammasome crucial pathogenesis In present study, was shown to be proinflammatory metabolite neuroimmune signaling network mediating...
EGFRC797S mutation inducing resistance against third generation EGFR inhibitor drugs is an emerging "unmet clinical need" for nonsmall cell lung cancer patients. The pyrimidopyrimidinone derivative JND3229 was identified as a new highly potent with single digit nM potency. It also exhibited good in vitro and vivo monodrug anticancer efficacy xenograft mouse model of BaF3/EGFR19D/T790M/C797S cells. A high-resolution X-ray crystallographic structure determined to elucidate the interactions...
An enzyme-responsive colon-specific delivery system was developed based on hollow mesoporous silica spheres (HMSS) to which biodegradable chitosan (CS) attached via cleavable azo bonds (HMSS-N=N-CS). Doxorubicin (DOX) encapsulated in a noncrystalline state the cavity and mesopores of HMSS with high loading amount 35.2%. In vitro drug release proved that HMSS-N=N-CS/DOX performed release. The grafted CS could increase biocompatibility stability reduce protein adsorption HMSS. Gastrointestinal...
Tuberous sclerosis complex (TSC) is a disease featuring devastating and therapeutically challenging neurological abnormalities. However, there lack of specific neural progenitor cell models for TSC. Here, the pathology TSC was studied using primitive stem cells (pNSCs) from patient presenting c.1444-2A>C mutation in TSC2. We found that TSC2 pNSCs had higher proliferative activity increased PAX6 expression compared with those control pNSCs. Neurons differentiated showed enlargement soma,...
3-Bromopyruvate (3BP) is an energy-depleting drug that inhibits Hexokinase II activity by alkylation during glycolysis, thereby suppressing the production of ATP and inducing cell death. As such, 3BP can potentially serve as anti-tumorigenic agent. Our previous research showed induce apoptosis via AKT /protein Kinase B signaling in breast cancer cells. Here we found also colon death necroptosis at same time concentration SW480 HT29 lines; latter, autophagy was to be a mechanism In cells,...
Chemoresistance is an inevitable occurrence in lung adenocarcinoma, which has been associated with decreased expression of the phosphatase and tensin homolog deleted on chromosome ten (PTEN). Therefore, it important to identify novel molecular mechanisms suppress chemoresistance adenocarcinoma cells. Paclitaxel- cisplatin-resistant A549 carcinoma cell derivatives were developed by long-term serial culture. The metastatic properties cells assessed using wound-healing assays, migration...
Abstract Lung cancer is one of the most aggressive cancers with poor prognosis and high resistance rate. The family signal transducer activator transcriptions (STATs) appears to modulate in non-small cell lung (NSCLC). In this work, we demonstrated that STAT3/ZEB1 a critical axis gefitinib resistance. STAT3-targeted inhibition therefore new potential therapeutic strategy for cancer. Our small molecule screening identified relatively specific inhibitor, LL1. Pharmacological biochemical...
Abstract This study looked at different nitrogen sources used to make nitrogen-doped graphene composites loaded with gold. The structures and properties of the were compared. Nitrogen-doped (N-G) was prepared by hydrothermal synthesis. Gold nanoparticles (AuNPs) into samples Au/N-G composites. materials as well gold nano-nitrogen-doped (Au/N-G) compared TEM, SEM, XPS, Cyclic voltammetry scanning. Adding urea N-G makes them have more surface pleats folds, a larger area graphene, better...
Are any novel mutations and corresponding new phenotypes, other than recurrent hydatidiform moles, seen in patients with MEI1 mutations?We identified several causing phenotypes of early embryonic arrest implantation failure.It has been reported that biallelic MEI1, encoding meiotic double-stranded break formation protein 1, cause azoospermia men moles women.We first focused on a pedigree which two sisters were diagnosed December 2018. After genetic analysis, identified. We then expanded the...
The approval of poly(ADP-ribose) polymerase (PARP) inhibitor AZD2281 in 2014 marked the successful establishment therapeutic strategy targeting homologous recombination repair defects cancers clinic. However, has poor water solubility, low tissue distribution and relatively weak vivo anticancer activity, which appears to become limiting factors for its clinical use. In this study, we found that mefuparib hydrochloride (MPH) was a potent PARP inhibitor, possessing prominent vitro activity....
Oocyte maturation and fertilization are fundamental processes for successful human reproduction, abnormalities in these will cause infertility. Recently, we identified biallelic mutations CDC20 that responsible oocyte arrest, failure, early embryonic development arrest. In this study, screened further a new cohort of patients with maturation, fertilization, development. Through whole-exome sequencing, the four novel c.887G > A (p. Arg296Gln), c.964C T (p.Arg322 ∗ ), c.1155G C...
Traditional Chinese medicine (TCM) is important in the provision of anti-tumor drugs. Recently, studies have shown that certain types TCM agents are able to control growth tumors, enhance body's immune function and therapeutic effect chemotherapeutic In women, breast carcinoma most common tumor type second cause death from cancer. Polygonatum odoratum (P. odoratum) commonly used TCM. The aim present study was investigate effects P. extract on proliferation apoptosis MDA-MB-231 cancer cells....
Major depressive disorder (MDD) is an important and highly prevalent mental characterized by anhedonia a lack of interest in everyday activities. Additionally, patients with MDD appear to have deficits various cognitive abilities. Although number studies investigating the central auditory processing low-level sound features demonstrated that this population exhibits impairments automatic processing, influence emotional voice has yet be addressed. To explore prosodies MDD, we analyzed ability...
Hsp90 proteins are important therapeutic targets for many anti-cancer drugs in clinical trials. Geldanamycin (GA) was identified as the first natural inhibitor of Hsp90, increasing evidence suggests that GA not a good choice In this study, we investigated two new non-benzoquinone geldanamycin analogs inhibitors, DHQ3 and 17-demethoxy-reblastatin (17-DR), to explore molecular mechanisms their activity vivo vitro. MTT colony formation assays were used measure cell viability. Flow cytometry,...
Activating KRAS mutations are the most common drivers in development of non-small cell lung cancer (NSCLC). However, unsuccess treatment by direct inhibition has been proven. Deregulation PI3K signaling plays an important role tumorigenesis and drug resistance NSCLC. The activity PI3Kα-selective against KRAS-mutated NSCLC remains largely unknown.Cell proliferation was detected sulforhodamine B assay. Cell cycle distribution apoptosis were measured flow cytometry. assessed Western blot...
Abstract Shikonin is the main component of traditional Chinese medicine comfrey, which can inhibit activity PKM2 by regulating glycolysis and ATP production. Rheumatoid arthritis synovial cells (RA-FLSs) have been reported to increase glycolytic other similar hallmarks metabolic activity. In this study, we investigated effects shikonin on glycolysis, mitochondrial function, cell death in RA-FLSs. The results showed that induced apoptosis autophagy RA-FLSs activating production reactive...