A5053494980- Magnolia and Illicium research
- Bioactive natural compounds
- Natural product bioactivities and synthesis
- Microbial Natural Products and Biosynthesis
- Bioactive Compounds and Antitumor Agents
- Oxidative Organic Chemistry Reactions
- Heat shock proteins research
- Plant biochemistry and biosynthesis
- Toxin Mechanisms and Immunotoxins
- Phytochemical Studies and Bioactivities
- PI3K/AKT/mTOR signaling in cancer
- Cell death mechanisms and regulation
- Cancer, Hypoxia, and Metabolism
- Dendrimers and Hyperbranched Polymers
- Ubiquitin and proteasome pathways
- Hops Chemistry and Applications
- Synthesis of Organic Compounds
- Flavonoids in Medical Research
- Autophagy in Disease and Therapy
- Pharmacological Effects of Natural Compounds
- Chromatography in Natural Products
- Glycosylation and Glycoproteins Research
- Plant Gene Expression Analysis
- Fungal Plant Pathogen Control
- Computational Drug Discovery Methods
Bengbu Medical College
2015-2024
Anhui Science and Technology University
2023-2024
Korea Research Institute of Bioscience and Biotechnology
2009-2012
Korea University
2008
Geldanamycin (GM) is a naturally occurring anticancer agent isolated from several strains of Streptomyces hygroscopicus. However, its potential clinical utility compromised by severe toxicity and poor water solubility. For this reason, considerable efforts are under way to make new derivatives that have both good efficacy high On the other hand, glycosylation often step improves solubility and/or biological activity in many natural products biosynthesis. Here, we report facile production...
The aims of the present study were to examine hepatoprotective effect Scutellaria baicalensis Georgi extract (Scutellariae Radix extract; SRE) against acute alcohol‑induced liver injury in mice, and investigate mechanism endoplasmic reticulum (ER) stress. High performance liquid chromatography was used for phytochemical analysis SRE. Animals administered orally with 50% alcohol (12 ml/kg) 4 h following administration doses SRE every day 14 days, exception normal control group. protective...
Tailor made: We report the rational biosynthesis of C15 hydroxylated non-quinone geldanamycin analogues by site-directed mutagenesis polyketide synthase (PKS), together with a combination post-PKS tailoring genes. Rational biosynthetic engineering allowed generation derivatives, such as DHQ3 illustrated in figure, which had superior pharmacological properties comparison to parent compound. A approach was applied optimization benzoquinone ansamycin, geldanamycin. Geldanamycin and its natural...
The hexokinase inhibitor 3-bromopyruvate (3-BrPA) can inhibit glycolysis in tumor cells to reduce ATP production, resulting apoptosis. However, as 3-BrPA is an alkylating agent, its cytotoxic action may be induced by other molecular mechanisms. results presented here reveal that 3-BrPA-induced apoptosis caspase independent. Further, induces the generation of reactive oxygen species MDA-MB-231 cells, leading mitochondria-mediated These suggest caspase-independent species. In this study, we...
Traditional Chinese medicine (TCM) is important in the provision of anti-tumor drugs. Recently, studies have shown that certain types TCM agents are able to control growth tumors, enhance body's immune function and therapeutic effect chemotherapeutic In women, breast carcinoma most common tumor type second cause death from cancer. Polygonatum odoratum (P. odoratum) commonly used TCM. The aim present study was investigate effects P. extract on proliferation apoptosis MDA-MB-231 cancer cells....
Standardized treatment guidelines and effective drugs are not available for human triple-negative breast cancer (TNBC). Many efforts have recently been exerted to investigate the efficacy of natural compounds as anticancer agents owing their low toxicity. However, no study has examined effects isobavachalcone (IBC) on programmed cell death (PCD) MDA-MB-231 cells. In this study, IBC substantially inhibited proliferation cells in concentration- time-dependent manners. addition, we found that...
In this study, seventeen isobavachalcone (IBC) derivatives (1–17) were synthesised, and evaluated for their cytotoxic activity against three human lung cancer cell lines. Among these derivatives, compound 16 displayed the most potent H1975 A549 cells, with IC50 values of 4.35 14.21 μM, respectively. Compared IBC, exhibited up to 4.11-fold enhancement on non-small cells. addition, we found that suppressed cells via inducing apoptosis necroptosis. The initial mechanism induced death in...
Magnolol (MAG), a biphenolic neolignan, has various biological activities including antitumor effects. In this study, 15 MAG derivatives were semi-synthesized and evaluated for their in vitro anticancer activities. From these derivatives, compound 6a exhibited the best cytotoxic activity against four human cancer cell lines, with IC50 values ranging from 20.43 to 28.27 μM. Wound-healing transwell assays showed that significantly inhibited migration invasion of MDA-MB-231 cells. addition,...
A series of bakuchiol derivatives were synthesized and evaluated for their anti-proliferative the inhibitory activities on SMMC7721 cell line migration using PX-478 as a positive control. The results showed (S,E)-4-(7-methoxy-3,7-dimethyl-3-vinyloct-1-en-1-yl)phenol (10) to have best activity among tested compounds, which included PX-478. In addition, compound 10 greater than that in transwell invasion assays at every dose. western blotting tests, promising ability downregulate expression...
Nasopharyngeal carcinoma (NPC) is a common malignant head and neck tumor. Drug resistance distant metastasis are the predominant cause of treatment failure in NPC patients. Hispidulin flavonoid extracted from bioassay-guided separation EtOH extract Salvia plebeia with strong anti-proliferative activity nasopharyngeal cells (CNE-2Z). In this study, effects hispidulin on proliferation, invasion, migration, apoptosis were investigated CNE-2Z cells. The...
Shikonin, a natural naphthoquinone, has attracted much attention due to its various biological activities. Two shikonin glucosides, shikonin-1',8-di-O-β-D-glucopyranoside (1) and shikonin-1'-O-β-D-glucopyranoside (2), were biosynthesized through in vitro enzymatic glycosylation their structures elucidated using spectroscopic techniques. The water-solubility stability of compounds 1 2 significantly higher than those the parent compound. Furthermore, compound showed moderate cytotoxicity...