A5005812131- Obstructive Sleep Apnea Research
- Spine and Intervertebral Disc Pathology
- Medical Imaging Techniques and Applications
- Peptidase Inhibition and Analysis
- Radiomics and Machine Learning in Medical Imaging
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Spinal Fractures and Fixation Techniques
- Lung Cancer Diagnosis and Treatment
- Cancer, Hypoxia, and Metabolism
- Protease and Inhibitor Mechanisms
- Musculoskeletal pain and rehabilitation
- Esophageal Cancer Research and Treatment
- Medical Imaging and Analysis
- RNA modifications and cancer
- Immune Cell Function and Interaction
- Respiratory Support and Mechanisms
- Lung Cancer Treatments and Mutations
- Neuroscience of respiration and sleep
- Gastric Cancer Management and Outcomes
- Epigenetics and DNA Methylation
- CAR-T cell therapy research
- Ferroptosis and cancer prognosis
- Cancer-related gene regulation
- Sleep and Wakefulness Research
Bengbu Medical College
2023-2025
Peking University
2013-2025
Peking University People's Hospital
2015-2025
Chinese PLA General Hospital
2019-2025
Chengdu Medical College
2025
Affiliated Hospital of North Sichuan Medical College
2013-2024
Nantong University
2021-2023
Tongji University
2014-2023
Shanghai Pulmonary Hospital
2014-2023
Air Force Medical University
2023
Hypoxia is an important characteristic of most solid malignancies, and closely related to tumor prognosis therapeutic resistance. one the factors associated with resistance conventional radiotherapy chemotherapy. Therapies targeting hypoxia have attracted considerable attention. Hypoxia-activated prodrugs (HAPs) are bioreductive drugs that selectively activated under hypoxic conditions can accurately target regions tumors. Both single-agent combined use other shown promising antitumor...
Cage subsidence (CS) was previously reported as one of the most common complications following oblique lumbar interbody fusion (OLIF). We aimed to assess impacts CS on surgical results OLIF combined with anterolateral fixation, and determine its radiological characteristics well related risk factors.Two hundred forty-two patients who underwent at L4-5 a minimum 12 months follow-up were reviewed. Patients divided into three groups according extent disk height (DH) decrease during follow-up:...
Background: Studies have shown that the expression of histone deacetylases (HDACs) is significantly related to tumor microenvironment (TME) in gastric cancer. However, a single molecule or several molecules does not accurately reflect TME characteristics guide immunotherapy Methods: We constructed an HDAC score (HDS) based on level HDACs. The single-cell transcriptome was used analyze underlying factors contributing differences immune infiltration between patients with high and low HDS. In...
Accumulating evidence has demonstrated that N6-methyladenosine (m6A) plays important roles in various cancers, making it essential to profile m6A modifications at a transcriptome-wide scale colorectal cancer (CRC). In the present study, we performed high-throughput sequencing determine methylome CRC. We obtained six pairs of CRC samples and tumour-adjacent normal tissues from Peking University People's Hospital. used MeRIP-seq compared tissues, had 1343 dysregulated peaks, 625 peaks were...
Aberrant programmed cell death protein 1 (PD-1) expression on the surface of T cells is known to inhibit effector activity and play a pivotal role in tumor immune escape; thus, maintaining an appropriate level PD-1 great significance. We identified KLHL22, adaptor Cul3-based E3 ligase, as major PD-1-associated that mediates degradation before its transport surface. KLHL22 deficiency leads overaccumulation PD-1, which represses antitumor response promotes progression. Importantly, was...
As the most widespread mRNAs modification, N6-methyladenosine (m6 A) is dynamically and reversibly modulated by methyltransferases demethylases. ALKBH5 a major demethylase, plays vital roles in progression of cancers. However, role mechanisms colorectal cancer (CRC) unclear.Herein, we discovered that CRC, downregulated was closely related to poor prognosis CRC patients. Functionally, our results demonstrated knockdown enhanced proliferation, migration invasion LOVO RKO vitro, while...
A novel ring-worn oximeter (Circul) uses reflective photoplethysmography and automated signal processing to calculate oxygen desaturations. We evaluated the ability of Circul detect obstructive sleep apnea in Chinese adults.We recruited 207 Han subjects: 70% males, mean age 48.2±14.7 years, BMI 27.6±4.8 kg/m2 AHI 28.6±25.2 events/h. All participants underwent simultaneous polysomnography (PSG) testing a laboratory. Oxygen desaturation index (ODI), saturation (MSpO2), cumulative time at...
To evaluate the performance of a portable monitor (Nox-T3, Nox Medical Inc. Reykjavik, Iceland) used to diagnose obstructive sleep apnea in Chinese adults.Eighty adults (mean ± standard deviation age 47.6 14.0 years, 77.5% males, body mass index 27.5 5.4 kg/m2) underwent overnight, unattended home testing (HSAT) with Nox-T3 followed by an overnight in-laboratory polysomnogram (PSG) simultaneous recording. The recordings were scored using automated analysis and then manually edited different...
Mesenchymal stem cells-conditioned medium (MSC-CM) provides a promising cell-free therapy for Alzheimer's disease (AD) mainly due to the paracrine of MSCs, but precise mechanisms remain unclear. Studies suggests that mitochondrial dysfunction precedes accumulation amyloid-β plaques and neurofibrillary tangles, involves in onset development AD.In present study, we evaluated protective effects explored related-mitochondrial human umbilical cord derived MSC-CM (hucMSC-CM) an AD model vitro.To...
Abstract Increasing evidence has clarified that the tumor microenvironment (TME) is closely related to prognosis and therapeutic efficacy of cancer. However, there no reliable TME evaluation system used accurately predict in gastric We evaluated immune score (IMS) 1422 cancer samples based on 51 cell signatures. explored relationship between IMS prognosis, infiltration, subtype, potential escape mechanisms. The results show activation stroma decreased levels infiltration were associated with...
Emerging studies have focused on ways to treat cancers by modulating T cell activation. However, whether B receptor signaling in the tumor microenvironment (TME) can be harnessed for immunotherapy is unclear. Here, we report that an Asia-specific variant of human IgG1 containing a Gly396 Arg396 substitution (hIgG1-G396R) conferred improved survival patients with colorectal cancer (CRC). Mice knockin murine functional homolog mIgG2c-G400R recapitulated alleviated tumorigenesis and progression...
Accumulating evidence indicated that circular RNAs (circRNAs) directly sponge to microRNAs (miRNAs),(miRNAs), which in turn regulate the gene expression and affect malignancy behavior at posttranscriptional level. However, levels, function, mechanism of circ_0000231 colorectal cancer (CRC) are largely unknown. The levels circ_0000231, miR-140-3p, Bcl-2 110 CRC tissues matched normal were detected by qRT-PCR method. suppressed siRNA, miR-140-3p was overexpressed RNA mimics cell lines....
Aims: Radiation-induced pneumonia (RP) is a common complication after radiotherapy for clinical thoracic tumors, and increasing evidence suggests that miRNAs have potential value in regulating radiation-induced lung injury. However, the mechanism still obscure. Here, we evaluated miRNAs-dependent involved progression of RP. Results: Our data showed mmu-miR-208a-3p was consistently highly expressed tissue irradiated mice. In vitro studies demonstrated expression miR-208a-3p cells...
ABSTRACT Objective Spouses of young and middle‐aged patients diagnosed with breast cancer encounter various challenges, among which fear recurrence (FCR) is particularly prominent. This study aimed to identify distinct FCR trajectories investigate related factors. Methods A longitudinal was conducted 230 spouses at a medical college affiliated hospital in China. assessed five time points: 1–3 days before the surgery 7 months after surgery. growth mixture model used latent categories...