A5101888030- Moyamoya disease diagnosis and treatment
- Intracranial Aneurysms: Treatment and Complications
- Neurological Complications and Syndromes
- Cerebrovascular and Carotid Artery Diseases
- Cerebrovascular and genetic disorders
- Connective tissue disorders research
- Influenza Virus Research Studies
- Aortic Disease and Treatment Approaches
- Anesthesia and Neurotoxicity Research
- Neuroscience and Neuropharmacology Research
- High Altitude and Hypoxia
- Mesenchymal stem cell research
- Acute Myeloid Leukemia Research
- Otitis Media and Relapsing Polychondritis
- Cancer, Hypoxia, and Metabolism
- Cardiac Ischemia and Reperfusion
- vaccines and immunoinformatics approaches
- RNA Interference and Gene Delivery
- Autophagy in Disease and Therapy
- Asthma and respiratory diseases
- Kruppel-like factors research
- RNA modifications and cancer
- Immunotherapy and Immune Responses
- IL-33, ST2, and ILC Pathways
- Myeloproliferative Neoplasms: Diagnosis and Treatment
Chinese PLA General Hospital
2019-2024
PLA Academy of Military Science
2023-2024
307th Hospital of Chinese People’s Liberation Army
2012-2023
Pharmaceutical Biotechnology (Czechia)
2021
Nanjing University
2021
First Affiliated Hospital of Anhui Medical University
2021
Anhui Medical University
2021
Shandong Provincial QianFoShan Hospital
2019
Shandong University
2019
Southern University of Science and Technology
2019
Background and Purpose— Predicting the risk of stroke determining intervention indications are highly important for patients with Moyamoya disease (MMD). Here, we evaluated a novel MMD grading system based on collateral circulation Suzuki stage to evaluate symptoms predict prognosis. Methods— In total, 301 idiopathic were retrospectively analyzed between 2014 2016. A scores ranging from 1 12 was established: anatomic extent pial blood flow posterior cerebral artery middle anterior scored 6;...
Mesenchymal stem cells-conditioned medium (MSC-CM) provides a promising cell-free therapy for Alzheimer's disease (AD) mainly due to the paracrine of MSCs, but precise mechanisms remain unclear. Studies suggests that mitochondrial dysfunction precedes accumulation amyloid-β plaques and neurofibrillary tangles, involves in onset development AD.In present study, we evaluated protective effects explored related-mitochondrial human umbilical cord derived MSC-CM (hucMSC-CM) an AD model vitro.To...
Acute myeloid leukemia (AML) is a cancer of the line blood cells, and generally considered to be caused by environment genetic factors. In this study, we combined genome-wide haplotype association study (GWHAS) gene prioritization strategy mine AML-related affect factors understand its pathogenesis. A total 175 AML patients were downloaded from public GEO database (GSE32462) 218 matched Caucasian controls HapMap Project. We first identified linkage disequilibrium (LD) blocks performed GWHAS...
Background: Bupivacaine (BUP) acts as a local anesthetic, which is extensively used for clinical patients but could generate neurotoxicity in neurons. Tetramethylpyrazine (TET) exhibits strong neuron protective effects against neurotoxicity. Hence, we investigate the effect of TET on BUP-induced SH-SY5Y cells. Methods: CCK-8 assay was to detect cell proliferation In addition, Western blotting examine Bax, Bcl-2, active caspase 3, LC3II, Beclin 1 and p-62 protein levels Moreover, ELISA total...
When ascending to high altitude, it is a rigorous challenge people who living in the low altitude area acclimatize hypoxic environment. Hypoxia exposure can cause dramatic disturbances of metabolism. This longitudinal cohort study was conducted delineate plasma metabolomics profile following environments and explore potential metabolic changes after return area. 25 healthy volunteers (Nor; 40m) were transported (HA; 3,650m) for 7-day sojourn before back (HAP; 40m). Plasma samples collected...
Recent studies found that microembolic signals (MESs) could be detected by transcranial Doppler in patients with moyamoya disease. However, the clinical significance of MESs disease remains unclear. Our aim was to investigate whether predict cerebral ischaemic events disease.Fifty-four consecutive were recruited. monitored for 30 min bilateral middle arteries each patient on admission. Patients followed up 1 year. The primary end-point including stroke and transient attack (TIA).MESs 11...
Previous studies have found significant differences in clinical characteristics between pediatric and adult moyamoya disease (MMD) patients, but few focused on the factors underlying these differences. We aimed to investigate leptomeningeal collateral (LMC) status MMD patients analyze effects of LMCs therapeutic prognosis.We retrospectively analyzed 214 from January 2014 2016. Clinical LMC were compared patients. was graded as good or poor depending retrograde flow posterior cerebral artery...
OBJECTIVE The aim of this study was to develop and validate a predictive nomogram model for long-term rebleeding events in patients with hemorrhagic moyamoya disease (HMMD). METHODS In total, 554 HMMD from the Fifth Medical Center Chinese PLA General Hospital (5-PLAGH cohort) were included randomly divided into training (390 patients) internal validation (164 sets. An independent cohort First Eighth (the 1-PLAGH 8-PLAGH used external (133 patients). Univariate Cox regression analysis least...
This study aimed to explore the long-term course of posterior circulation changes and predictors in patients with moyamoya disease (MMD).The authors retrospectively enrolled who were diagnosed MMD underwent encephaloduroarteriosynangiosis (EDAS) surgery at authors' department from December 2002 September 2011. A comparative between short-term (6-12 months) (≥ 9 years) follow-up angiography was conducted. The progression lesions defined lower higher stages cerebral artery (PCA).Eighty-eight...
Abstract Background and purpose The penetrance of the RNF213 p.R4810K, a founder mutation moyamoya disease (MMD), is estimated to be only 1/150–1/300. However, factors affecting its remain unclear. Therefore, our study aims identify modifier genes associated with incomplete this mutation. Methods Whole‐exome sequencing (WES) was performed on 36 participants, including 22 MMD patients 14 non‐MMD controls p.R4810K Fisher's exact test used assess presence genetic variants that differed...
An HLA imputation was conducted to explore the relationship between and patients with moyamoya disease (MMD) in Chinese Han population.In this study, we performed an association analysis of major histocompatibility complex region 2,786 individuals ancestry (2,031 controls 755 MMD), through a widely used method.We identified that variant rs3129731 (odds ratio [OR] = 1.79, p 3.69 × 10-16) located MTCO3P1 HLA-DQA2 is genetic risk factor for MMD. In addition variant, found conditional analysis,...
Objective To detect the serum levels of angiogenic factors and inflammatory cytokines in patients with moyamoya disease explore their roles pathogenesis disease. Methods The vascular endothelial growth factor (VEGF), angiopoietin-1 (Ang-1), interleukin-8 (IL-8), granulocyte colony stimulating (G-CSF), granulocyte-macrophage (GM-CSF) monocyte chemotactic protein 1 (MCP-1) 56 26 healthy controls were measured by cytometric bead array. Results The VEGF (2.81±1.77 pg/ml vs.1.98±0.66...
Background and purpose Moyamoya disease is a cerebrovascular disorder characterized by bilateral progressive stenosis occlusion of terminal portions internal carotid artery (ICA) accompanying typical net-like collateral vessels. Patients with both the characteristic moyamoya vasculopathy associated conditions are categorized as syndrome. These include sickle cell disease, neurofibromatosis type 1, Down’s cranial therapeutic irradiation other rare diseases. syndrome Graves’ has been rarely...
Objective To preliminarily explore the clinical features, treatment, and outcomes of moyamoya disease in elderly. Methods The data elderly patients with (aged >60 years) admitted to Department Neurosurgery, 307th Hospital PLA from May 2007 July 2016 were collected retrospectively. Their imaging surgical analyzed. Results A total 68 enrolled, including 35 females (51.47%) 33 males (48.53%). The ratio male female was 1∶1.06. age at time diagnosis 62.82±3.08 years. Fifty-two...