A5114594108- Hearing, Cochlea, Tinnitus, Genetics
- Neuroinflammation and Neurodegeneration Mechanisms
- Neurogenesis and neuroplasticity mechanisms
- Functional Brain Connectivity Studies
- Ion Channels and Receptors
- Neurological Disease Mechanisms and Treatments
- Neuroscience and Neuropharmacology Research
- Tryptophan and brain disorders
- Neurological Disorders and Treatments
- Memory and Neural Mechanisms
- Vestibular and auditory disorders
- Ocular Diseases and Behçet’s Syndrome
- Connexins and lens biology
- Extracellular vesicles in disease
- Neuroscience and Neural Engineering
- Vagus Nerve Stimulation Research
- Nerve injury and regeneration
- Autoimmune and Inflammatory Disorders
- Hearing Loss and Rehabilitation
- Advanced Neuroimaging Techniques and Applications
- Cardiac Arrhythmias and Treatments
- Central Venous Catheters and Hemodialysis
- Traditional Chinese Medicine Analysis
- Planarian Biology and Electrostimulation
- Inflammasome and immune disorders
Augusta University
2022-2025
Chinese PLA General Hospital
2024
Second Xiangya Hospital of Central South University
2015-2024
Central South University
2015-2024
University of Toronto
2024
Wenzhou Medical University
2022
Affiliated Eye Hospital of Wenzhou Medical College
2022
University of Alabama
2019
Fujian University of Traditional Chinese Medicine
2016-2017
Shandong University of Traditional Chinese Medicine
2017
The function and regulation of different heterogeneous reactive states astrocytes in depression remain unclear. Here, we demonstrate that neurotoxic (A1-like) are strongly induced, prior to behavioral impairments dendritic atrophy, depression-like mice. More interestingly, global or microglia-specific knockout Nod-like receptor protein 3 (Nlrp3) markedly mitigates A1-like astrocyte induction, whereas astrocyte-specific Nlrp3 depletion is ineffective. Microglial ablation also alleviates the...
Previous studies provide evidence that aging is associated with the decline of memory function and alterations in hippocampal function, including functional connectivity to medial prefrontal cortex (mPFC). In this study, we investigated if longitudinal (12-week) Tai Chi Chuan Baduanjin practice can improve modulate resting-state (rs-FC). Memory measurements resting state Magnetic Resonance Imaging (rs-fMRI) were applied at beginning end experiment. The results showed 1) quotient (MQ)...
Disturbed remodeling of the extracellular matrix (ECM) is frequently observed in several high-prevalence pathologies that include fibrotic diseases organs such as heart, lung, periodontium, liver, and stiffening ECM surrounding invasive cancers. In many these lesions, mediated by fibroblasts dysregulated, part alterations to regulatory effector systems synthesize degrade collagen, functions integrin-based adhesions normally mediate mechanical collagen fibrils. Cell-matrix containing...
Abstract Ca 2+ permeation through TRPV4 in fibroblasts is associated with pathological matrix degradation. In human gingival fibroblasts, IL‐1β binding to its signaling receptor (IL‐1R1) induces activation of extracellular regulated kinase (ERK) and MMP1 expression, processes that require flux across the plasma membrane. It not known how IL‐1R1, which does conduct , generates signals response IL‐1. We examined whether mediates fluxes required for ERK IL‐1 stimulated fibroblasts. was...
Amnestic mild cognitive impairment (aMCI) is characterized by functional decline, especially in memory. Resting-state magnetic resonance imaging (fMRI) has been widely used neuroimaging studies that explore alterations between patients and normal individuals to elucidate the pathological mechanisms of different diseases. The current study was performed investigate connectivity default mode network (DMN) aMCI compared healthy elderly controls, as well further define association neurological...
Background The autonomic nervous system (ANS) plays a key role in regulating tumor development and therapy resistance various solid tumors. Within the ANS, sympathetic (SNS) is typically associated with protumor effects. However, whether SNS influences antitumor efficacy of intratumoral injections oncolytic herpes simplex virus (oHSV) tumors remains unknown. Methods In this study, we examined innervation its interaction immune cell infiltration both human murine triple-negative breast cancer...
Abstract Stroke has become the leading cause of mortality worldwide. Hypoxic or ischemic insults are crucial factors mediating neural damage in brain tissue stroke patients. Neural stem cells (NSCs) have been recognized as a promising tool for treatment and other neurodegenerative diseases due to their inducible pluripotency. In this study, we aim mimick cerebral hypoxic‐ischemic injury vitro using oxygen–glucose deprivation (OGD) strategy, evaluate effects OGD on NSC's differentiation, well...
Post-stroke memory dysfunction (PMD) is one of the most common forms cognitive impairment among stroke survivors. However, only a limited number studies have directly investigated neural mechanisms associated with decline. The aim present study was to identify dynamic changes in functional organization default mode network (DMN) and dorsal attention patients PMD. A total 27 PMD who experienced right hemisphere were enrolled current study, along healthy control subjects matched by age, sex,...
Behcet's disease is a multi‑system inflammatory disorder, and ocular (OBD) one of the most common causes uveitis in China. A number studies have indicated that Th17 cells, subset interleukin-17 (IL-17)-producing CD4+ T‑helper serve important roles pathogenesis OBD. Berberine (BBR) an isoquinoline derivative alkaloid isolated from Chinese herbs, has been used traditionally for treatment gastrointestinal disorders. The aim present study was to investigate effect BBR on cell proliferation...
NOD-like receptor family pyrin domain containing 3 (NLRP3) inflammasome contributes to the development of cisplatin-induced ototoxicity. Whether heat shock pretreatment could be utilized up-regulate 70 kilodalton proteins (HSP70) expression in bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (HS-BMSC-Exo) alleviate ototoxicity is deciphered this study. Heat was performed on BMSCs induce HS-BMSC-Exo, which were further trans-tympanically administrated into cisplatin...
Chronic cerebral hypoperfusion (CCH) is a common risk factor for vascular dementia and Alzheimer’s disease (AD). The previous studies have shown that CCH-induced multiple AD-like pathological changes in the hippocampus cortex through downregulating microRNA-195 (miR-195) expression. However, whether how miR-195 participates dysfunction of medial septum (MS)-dorsal hippocampal CA1 (dCA1) neural circuit following CCH still obscure. In present study, we found was downregulated MS...
Both hypoxia preconditioning and exosomes derived from bone marrow mesenchymal stem cells (BMSC-Exo) have been adopted to alleviate hair-loss-related ototoxicity. Whether hypoxic BMSCs-derived (hypBMSC-Exo) could cisplatin-induced ototoxicity is investigated in this study. Cisplatin intraperitoneally injected C57BL/6 mice were trans-tympanically administered BMSC-Exo or hypBMSC-Exo the left ear. Myosin 7a staining was utilized detect mature hair cells. Auditory brainstem response (ABR)...
Abstract Hereditary deafness is a common neurosensory disorder, and 148 non‐syndromic genes have been identified to date. Gene therapy has used treat variety of genetic diseases, but no gene drug for hereditary approved clinical use. At present, several trials are underway. However, few normative documents issued guide the standardization hearing loss, this document first global guideline loss. The guidelines were jointly developed drafted by experienced audiologists, virologists biologists...
Damage to the cochlear sensory epithelium is a key contributor noise-induced sensorineural hearing loss (SNHL). KCNQ4 plays an important role in potassium circulation and outer hair cells survival. As miR-153 can target regulate KCNQ4, we sought study of SNHL. 12-week-old male CBA/J mice were exposed 2-20 kHz broadband noise at 96 dB SPL induce temporary threshold shifts 101 permanent shifts. Hearing was determined by auditory brainstem responses (ABR). Relative expression cochlea Real-Time...
Abstract Task‐dependent volitional control of the selected neural activity in cortex is critical to neuroprosthetic learning achieve reliable and robust external device. The driven by a motivational factor (volitional motivation), which directly reinforces target neurons via real‐time biofeedback. However, absence motor behaviour, how do we evaluate motivation? Here, defined criterion (Δ F / ) calcium fluorescence signal volitionally controlled task, then escalated efforts progressively...
Neuronal hearing loss has become a prevalent health problem. This study focused on the function of arctigenin (ARC) in promoting survival and neuronal differentiation mouse cochlear neural stem cells (NSCs), its protection against gentamicin (GMC) induced loss. Mouse cochlea was used to isolate NSCs, which were subsequently cultured vitro. The effects ARC NSC survival, neurosphere formation, neurite outgrowth, excitability network vitro examined. Mechanotransduction ability demonstrated by...