A5071128462- Parkinson's Disease Mechanisms and Treatments
- Alzheimer's disease research and treatments
- Advanced Glycation End Products research
- Biochemical effects in animals
- Mitochondrial Function and Pathology
- Birth, Development, and Health
- Neuroscience and Neuropharmacology Research
- Pregnancy and preeclampsia studies
- Genetic Neurodegenerative Diseases
- Veterinary medicine and infectious diseases
- Neuropeptides and Animal Physiology
- Adipose Tissue and Metabolism
- Crystallography and molecular interactions
- Essential Oils and Antimicrobial Activity
- Antibiotics Pharmacokinetics and Efficacy
- Alcohol Consumption and Health Effects
- Tryptophan and brain disorders
- Biochemical and biochemical processes
- Natural Antidiabetic Agents Studies
- Mycobacterium research and diagnosis
- Microbial infections and disease research
- Lipid Membrane Structure and Behavior
- Immune Response and Inflammation
- Metabolomics and Mass Spectrometry Studies
- Botulinum Toxin and Related Neurological Disorders
Health Research Institute of the Balearic Islands
2019-2024
Universitat de les Illes Balears
2019-2024
Research Institute of Health Sciences
2019-2023
Servei de Salut de les Illes Balears
2019-2022
Centro de Educación Médica e Investigaciones Clínicas Norberto Quirno
2017
Hospital Alemán
2001-2016
Charité - Universitätsmedizin Berlin
2016
University of Buenos Aires
2015
University of Córdoba
1991
Abstract The formation of a heterogeneous set advanced glycation end products (AGEs) is the final outcome non-enzymatic process that occurs in vivo on long-life biomolecules. This process, known as glycation, starts with reaction between reducing sugars, or their autoxidation products, amino groups proteins, DNA, lipids, thus gaining relevance under hyperglycemic conditions. Once AGEs are formed, they might affect biological function biomacromolecule and, therefore, induce development...
Abstract Parkinson’s disease (PD) is one of the most prevalent neurodegenerative disorders affecting worldwide population. One its hallmarks intraneuronal accumulation insoluble Lewy bodies (LBs), which cause death dopaminergic neurons. α-Synuclein (αS) main component these LBs and in them, it commonly contains non-enzymatic post-translational modifications, such as those resulting from reaction with reactive carbonyl species arising side products glycolysis (mainly methylglyoxal)....
Human α-synuclein is a small monomeric protein (140 residues) essential to maintain the function of dopaminergic neurons and neuronal redox balance. However, it holds dark side since able clump inside forming insoluble aggregates known as Lewy bodies, which are considered hallmark Parkinson's disease. Sporadic mutations nonenzymatic post-translational modifications well-known stimulate formation bodies. Yet, effect on has been studied less intense. Therefore, here we study how nitration...
Human alpha-synuclein (αS) is an intrinsically disordered protein highly expressed in dopaminergic neurons. Its amyloid aggregates are the major component of Lewy bodies, which considered a hallmark Parkinson's disease (PD). αS has four different Met, particularly sensitive to oxidation, as most them found Met sulfoxide (MetO) deposits. Consequently, researchers have invested mounting efforts trying elucidate molecular mechanisms underlying links between oxidative stress, aggregation and PD....
α-Synuclein (αS) is a presynaptic protein whose aggregates are considered as hallmark of Parkinson's disease (PD). Although its physiological function still under debate, it widely accepted that functions always mediated by interaction with membranes. The association αS phospholipid membranes occurs concomitant to folding from monomeric, unfolded state towards an antiparallel amphipathic α-helix. Besides this, copper ions can also bind and modify aggregation propensity. effect Cu(II) Cu(I)...
Frataxin is a mitochondrial protein which deficiency causes Friedreich’s ataxia, cardio-neurodegenerative disease. The lack of frataxin induces the dysregulation iron homeostasis and oxidative stress, finally neuronal death. mechanism through regulates stress balance rather complex poorly understood. While absence human (Hfra) yeast (Yfh1) frataxins turn out cells sensitive to this does not occur when gene knocked-out in E. coli. To better understand biological roles Hfra Yfh1 as endogenous...
Abstract The control of pre-analytical-factors in human biospecimens collected for health research is currently required. Only two previous reports using post-mortem brain samples have tried to address the impact cold-ischemia on tissue pH. Here we report pH variations according time (third-order polynomial model) mice liver, kidney and lung samples. Tissue alkalosis may be an underlying mechanism gene expression changes. Therefore, tissue-pH regulation after organ removal minimize biological stress
Abstract It is well‐known that people suffering from hyperglycemia have a higher propensity to develop Parkinson's disease (PD). One of the most plausible mechanisms linking these two pathologies glycation neuronal proteins and pathological consequences it. α‐Synuclein, key component in PD, can be glycated at its fifteen lysine. In fact, end products this process been detected on aggregated α‐synuclein isolated vivo . However, are not entirely clear, which crucial importance understand...
An enzyme-linked immunosorbent assay (ELISA) was performed for diagnosis of paratuberculosis in goats, using as antigen a protoplasmic extract (PPA-3). The test developed on the basis results obtained with two serum reference pools, positive and negative respectively. To avoid day-to-day variations, dilutions pool were included each plate to obtain an arbitrary system, transforming absorbance into immunoglobulin (Ig) G anti-Mycobacterium units. ELISA used sera groups animals. One group...
Parkinson's disease (PD) is the second most prevalent progressive neurodegenerative disorder after Alzheimer's disease. PD usually starts with a tremor in extremities (usually hands) and gradually evolves other symptoms such as bradykinesia, muscle stiffness, impaired posture, loss of automatic movements or speech changes. These worsen condition progresses eventually lead to death. results from deterioration dopamine-producing neurons substantia nigra, which are especially vulnerable owing...
Parkinson's disease (PD) is characterized by dopaminergic neuron degeneration and the accumulation of neuronal inclusions known as Lewy bodies, which are formed aggregated post-translationally modified α-synuclein (αS). Oxidative modifications such formation 3-nitrotyrosine (3-NT) or di-tyrosine found in αS deposits, they could be promoted oxidative stress typical PD brains. Many studies have tried to elucidate molecular mechanism correlating nitroxidation, aggregation, PD. However, it...
Objective: Severe forms of hypertensive disorders pregnancy, like early-onset preeclampsia (PE), are often linked with abnormal placentation. Genetic factors contributed by the father may be important for placental development, and previous studies support existence a paternal component PE fetal growth restriction. Thus, present study was conducted to evaluate influence arterial hypertension as factor on development in normal female rats. Design method: Female Wistar Kyoto rats (10–12 weeks...
Objective: Arterial hypertension (HT) affects 1–5% of pregnant women worldwide, with a rising prevalence due to increasing maternal age, obesity, and type 2 diabetes. Pregnancies complicated by HT increase the risk superimposed preeclampsia, fetal growth restriction (FGR), preterm delivery, perinatal death. So far, there is scarce information available on placental development function in severe animal models such as Stroke-Prone Spontaneously Hypertensive Rat (SHRSP) strain. Thus, present...
Obesity is a common disease associated with increased morbidity and mortality. Congestive heart failure has been documented as frequent complication of the morbid obesity regardless presence hypertension. The aim our study was to evaluate early changes in left ventricular mass (LVM) Zucker rats (fa/fa) incipient by echocardiography. Male rats: G1 fatty (ZRF) G2 (Fa/fa) lean (ZRL) at 10 weeks old were used for this experiment. Echocardiograms performed ATL HDI 3000 equipment mHz. transducer....