A5069526074- Gut microbiota and health
- Silymarin and Mushroom Poisoning
- Dietary Effects on Health
- Diet and metabolism studies
- Drug-Induced Hepatotoxicity and Protection
- Tryptophan and brain disorders
- Genetic and Kidney Cyst Diseases
- Berberine and alkaloids research
- Polyamine Metabolism and Applications
- Biomedical Research and Pathophysiology
- Endoplasmic Reticulum Stress and Disease
- Protein Tyrosine Phosphatases
- Chromium effects and bioremediation
- Genetic Syndromes and Imprinting
- Pediatric Urology and Nephrology Studies
- Algal biology and biofuel production
- Genomics, phytochemicals, and oxidative stress
- Enzyme Production and Characterization
- Renal and related cancers
- Nutrition, Genetics, and Disease
- Curcumin's Biomedical Applications
- Palliative and Oncologic Care
- Metabolomics and Mass Spectrometry Studies
- Galectins and Cancer Biology
- Congenital Anomalies and Fetal Surgery
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
2024-2025
Natura (Brazil)
2024-2025
Universidade de São Paulo
2021-2024
Instituto Mauá de Tecnologia
2015
It is known that obesity has a multifactorial etiology involves genetic and environmental factors. The WHO estimates the worldwide prevalence of 1.9 billion overweight adults more than 650 million people with obesity. These alarming data highlight high growing represent risk factor for development aggravation other chronic diseases, such as nonalcoholic fatty liver disease (NAFLD) frequently considered hepatic outcome type 2 diabetes. use non-pharmacological therapies food supplements,...
Abstract Overweight and obesity are closely linked to gut dysbiosis/dysmetabolism disrupted De‐Ritis ratio [aspartate aminotransferase (AST)/alanine (ALT) ratio], which may contribute chronic noncommunicable diseases onset. Concurrently, extensive research explores nutraceuticals, health‐enhancing supplements, for disease prevention or treatment. Thus, sedentary overweight volunteers were double‐blind randomized into two groups: Novel Nutraceutical_(S) (without silymarin) Nutraceutical (with...
Abstract Nutraceutical interventions supporting microbiota and eliciting clinical improvements in metabolic diseases have grown significantly. Chronic stress, gut dysbiosis, metainflammation emerged as key factors intertwined with sleep disorders, consequently exacerbating the decline quality of life. This study aimed to assess effects two nutraceutical formulations containing prebiotics (fructooligosaccharides (FOS), galactooligosaccharides (GOS), yeast β-glucans), minerals (Mg, Se, Zn),...
ABSTRACT This study explores the effects of a nutraceutical blend with prebiotics, β‐glucans, essential minerals, and silymarin on gut microbiota, inflammation, sleep quality in obesity through microbiota reshaping metabolic improvements over 90 days. A double‐blind, randomized trial was conducted 77 participants divided into two groups receiving either standard (NSupple) or silymarin‐enriched (NSupple_ Silybum ). Fecal plasma samples were collected at baseline post‐supplementation for...
Introduction Bioactive compounds and whole foods have emerged as promising interventions to address gut microbiota dysbiosis linked obesity. Compounds such berberine coenzyme Q10 are well-recognized for their roles in managing metabolic syndrome exerting antioxidant effects, while beet pulp, rich fiber antioxidants, enhances health through additional prebiotic benefits. Methods This study evaluated the effects of a nutraceutical supplement, Slim, on modulation obese mice induced by high-fat...
To evaluate the synergic effects of a novel oral supplement formulation, containing prebiotics, yeast β-glucans, minerals and silymarin (Silybum marianum), on lipid glycidic metabolism, inflammatory mitochondrial proteins liver, in control high-fat diet-induced obese mice.After an acclimation period, 32 male C57BL/6 mice were divided into following groups: nonfat diet (NFD) vehicle, NFD supplemented, (HFD) vehicle HFD supplemented. The experimental formulation administered orally by gavage...
The use of natural products and derivatives for the prevention control non-communicable chronic diseases, such as type-2 diabetes (T2D), obesity, hepatic steatosis is a way to achieve homeostasis through different metabolic pathways. Thus, male C57BL/6 mice were divided into following groups: high-fat diet (HFD) vehicle, HFD + Supplemented, Supplemented_S, isolated compounds. vehicle experimental formulations administered orally by gavage once day over four weeks (28 consecutive days). We...
Gut dysbiosis contributes to chronic inflammation and oxidative stress associated with metabolic syndrome, non-pharmacological, health-promoting supplements like nutraceuticals have been studied used as a way prevent or treat several illnesses. Thus, male C57BL/6 mice were divided into the following groups: control (CTL)_Vehicle CTL_Nutraceutical; high-fat diet (HFD)_Vehicle, HFD_Nutraceutical, HFD_Nutraceutical_S, isolated compounds. The vehicle experimental formulations administered by...
The search for integrative and natural therapies that favor homeostasis to boost sleep diet quality took place young adult populations as a non-pharmacological strategy long-term good of life. Thus, the present pilot study aims investigate effects 90-day consumption nutraceutical composition on neuro-immune-endocrine axis, providing better health improvement.
Silybum marianum (L.) Gaertn, commonly known as milk thistle, is an herbal medicine rich in silymarin, a bioflavonoid complex. Historically, silymarin was used for treating liver diseases, but recent studies highlight silymarin’s potential obesity management. This narrative review aims to provide in-depth examination of the existing knowledge and its secondary compounds concerning associated comorbidities, summarizing data from vitro, preclinical, clinical studies. Obesity significant public...
Abstract Smoking has been associated with renal disease progression in ADPKD but the underlying deleterious mechanisms and whether it specifically worsens cardiac phenotype remain unknown. To investigate these matters, Pkd1 -deficient cystic mice noncystic littermates were exposed to smoking from conception 18 weeks of age and, along nonexposed controls, analyzed at 13–18 weeks. Renal index cyst-lining cell proliferation higher than animals. increased serum urea nitrogen independently...
Stress, unhealthy lifestyle, and sleep disturbance worsen cognitive function in mood disorders, prompting a rise the development of integrative health approaches. The recent investigations gut–brain axis field highlight strong interplay among microbiota, inflammation, mental health. Thus, this study aimed to investigate new nutraceutical formulation comprising prebiotics, minerals, silymarin’s impact on mood, quality. evaluated LL1 + silymarin capsule supplementation over 180 days overweight...
O ambiente doméstico é um local que corriqueiramente acontecem acidentes durante a infância, colocando em risco vida de milhares crianças. Isso justifica-se, pois o espaço intradomiciliar pode proporcionar riscos para traumas, asfixias, queimaduras, entre outros agravos saúde. As evidências científicas revelam o desconhecimento e despreparo dos familiares na condução das situações emergenciais. Assim, práticas educativas saúde...
Abstract Silymarin, derived from Silybum marianum, has recently demonstrated its potential to improve health in conditions such as obesity and metabolic disturbances. Understanding the impact of nutraceuticals on intestinal morphology is crucial for developing supplements that promote a higher quality life. Therefore, this study aimed investigate effects nutraceutical supplementation with silymarin small intestine. Sixty-day-old adult male C57BL/6 mice were divided into two groups: one...
A procura por fontes alternativas de energia vem sendo continuamente estudada, haja vista a preocupação com o esgotamento recursos não renováveis e à pegada carbono envolvida. As microalgas, além competirem setor alimentos, apresentam altos teores carboidratos lipídios na composição, que as tornam uma das potenciais biomassa para produtos origem renovável. Nesse trabalho, foi estudada hidrólise ácida da Chlorella vulgaris, partir do prétratamento térmico produção açúcares fermentescíveis....