A5006008799- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Nicotinic Acetylcholine Receptors Study
- Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Cannabis and Cannabinoid Research
- Epilepsy research and treatment
- Neuroscience of respiration and sleep
- Adipose Tissue and Metabolism
- Nitric Oxide and Endothelin Effects
- Stress Responses and Cortisol
- Neuroinflammation and Neurodegeneration Mechanisms
- Youth, Drugs, and Violence
- Sleep and Wakefulness Research
- Pharmacological Effects and Toxicity Studies
- Climate Change and Health Impacts
- Ion Transport and Channel Regulation
- Memory and Neural Mechanisms
- Ginkgo biloba and Cashew Applications
- Alzheimer's disease research and treatments
- Ion channel regulation and function
- Forensic Toxicology and Drug Analysis
- Air Quality and Health Impacts
- Energy and Environment Impacts
- Psychedelics and Drug Studies
- Treatment of Major Depression
Universidade de São Paulo
2015-2024
Casper Líbero Foundation
2017
Instituto de Ciências Farmacêuticas
2010
Hospital das Clínicas da Faculdade de Medicina da Universidade de São Paulo
1999-2006
Pontifícia Universidade Católica do Rio Grande do Sul
1993
Epilepsy Foundation
1992
Hospital Nossa Senhora das Graças
1991
Oxidative stress has been associated with normal aging and Alzheimer's disease (AD). However, little is known about oxidative in mild cognitive impairment (MCI) patients who present a high risk for developing AD. The aim of this study was to i
The regular practice of physical exercise has been associated with beneficial effects on various pulmonary conditions. We investigated the mechanisms involved in protective effect a model lipopolysaccharide (LPS)-induced acute lung injury (ALI).Mice were divided into four groups: Control (CTR), Exercise (Exe), LPS, and + LPS (Exe LPS). Exercised mice trained using low intensity daily for five weeks. Exe received 200 µg intratracheally 48 hours after last test. measured exhaled nitric oxide...
The Metropolitan Area of São Paulo has a unique composition atmospheric pollutants, and positive correlations between exposure the risk diseases mortality have been observed. Here we assessed effects ambient fine particulate matter (PM2.5) on genotoxic global DNA methylation hydroxymethylation changes, as well activities antioxidant enzymes, in tissues AJ mice exposed whole body to air enriched PM2.5, which was concentrated chamber near an avenue intense traffic City, Brazil. Mice PM2.5 (1 h...
Background Brazil is the world's largest producer of sugarcane. Harvest predominantly manual, exposing workers to health risks: intense physical exertion, heat, pollutants from sugarcane burning. Design Panel study evaluate effects burnt harvesting on blood markers and cardiovascular system. Methods Twenty-eight healthy male workers, living in countryside were submitted markers, pressure, heart rate variability, cardiopulmonary exercise testing, sympathetic nerve activity evaluation forearm...
Exposure to environmental tobacco smoke (ETS) in the early postnatal period has been associated with several diseases; however, little is known about brain effects of ETS exposure during this critical developmental or long-term consequences exposure. This study investigated on both reference and working memory, synaptic proteins BDNF from late infancy adulthood (P3-P73). BALB/c mice were exposed generated 3R4F research cigarettes (0.73 mg nicotine/cigarette) P3 P14. Spatial memory evaluated...
Smoking crack cocaine involves the inhalation of and its pyrolysis product, anhydroecgonine methyl ester (AEME). Although there is evidence that neurotoxic, neurotoxicity AEME has never been evaluated. seems to have cholinergic agonist properties in cardiovascular system; however, are no reports on effects central nervous system. The aim this study was investigate possible rat primary hippocampal cell cultures were exposed different concentrations AEME, cocaine, a cocaine–AEME combination....
Abstract Environmental tobacco smoke (ETS) leads to the death of 600,000 nonsmokers annually and is associated with disturbances in antioxidant enzyme capacity adult rodent brain. However, little known regarding influence ETS on brain development. The aim this study was determine levels malonaldehyde (MDA) 3-nitrotyrosine (3-NT), as well enzymatic activities glutathione peroxidase (GPx), reductase (GR), S-transferase (GST), superoxide dismutase (SOD), distinct structures. BALB/c mice were...
Adolescence has been linked to greater risk-taking and novelty-seeking behavior a higher prevalence of drug abuse risk relapse. Decreases in cyclic adenosine monophosphate response element binding protein (CREB) phosphorylated CREB (pCREB) have reported after repeated cocaine administration animal models. We compared the behavioral effects abstinence adolescent adult mice investigated possible age-related differences pCREB levels. Adolescent male Swiss received one daily injection saline or...
Anacardic acids from cashew nut shell liquid, a Brazilian natural substance, have antimicrobial and antioxidant activities modulate immune responses angiogenesis. As inflammatory lung diseases been correlated to environmental pollutants exposure no reports addressing the effects of dietary supplementation with anacardic on inflammation in vivo evidenced, we investigated model diesel exhaust particle- (DEP-) induced inflammation. BALB/c mice received an intranasal instillation 50 μ g DEP for...
Formaldehyde is ubiquitous pollutant that induces oxidative stress in the lung. Several lung diseases have been associated with and their control necessary. Photobiomodulation therapy (PBMT) has highlighted as a promissory treatment, but its mechanisms need to be better investigated. Our objective was evaluate effects of PBMT on generated by FA exposure. Male Wistar rats were submitted exposure 1% or vehicle (3 days) treated not (1 5 h after each exposure). Rats only laser used control....
Behavioral sensitization, defined as a progressive increase in the locomotor stimulant effects elicited by repeated exposure to drugs of abuse, has been used an animal model for drug craving humans. The mesoaccumbens dopaminergic system proposed be critically involved this phenomenon; however, few studies have designed systematically investigate antagonists on development and expression behavioral sensitization ethanol Swiss mice. We first tested D(1) antagonist SCH-23390 (0-0.03 mg/kg) or...
Drug dependence is a major health problem in adults and has been recognized as significant adolescents. We previously demonstrated that repeated treatment with behaviorally sensitizing dose of ethanol adult mice induced tolerance or no sensitization adolescents ethanol-treated expressed lower Fos Egr-1 expression than the prefrontal cortex. In present work, we investigated effects acute administration on cyclic adenosine monophosphate response element-binding protein (CREB) DNA-binding...