A5078599670- Asthma and respiratory diseases
- Cardiac Ischemia and Reperfusion
- Immune Response and Inflammation
- Indoor Air Quality and Microbial Exposure
- Neonatal Respiratory Health Research
- Allergic Rhinitis and Sensitization
- Respiratory Support and Mechanisms
- Air Quality and Health Impacts
- Mast cells and histamine
- Adenosine and Purinergic Signaling
- Pediatric health and respiratory diseases
- Gut microbiota and health
- Neuroscience of respiration and sleep
- Inhalation and Respiratory Drug Delivery
- Tryptophan and brain disorders
- Neuropeptides and Animal Physiology
- Vagus Nerve Stimulation Research
- Cancer, Stress, Anesthesia, and Immune Response
- Neurotransmitter Receptor Influence on Behavior
- Nitric Oxide and Endothelin Effects
- Receptor Mechanisms and Signaling
- Anesthesia and Neurotoxicity Research
- Neurological Complications and Syndromes
- Nicotinic Acetylcholine Receptors Study
- Probiotics and Fermented Foods
Universidade de São Paulo
2013-2022
Hospital Universitário da Universidade de São Paulo
2020
Universidade Nove de Julho
2013
Universidade de Cuiabá
2013
Associação Brasileira de Oncologia Veterinária
2011
Conselho Nacional de Pesquisa e Pós-graduação em Direito
2007
We have previously shown that the prophylactic treatment with cannabidiol (CBD) reduces inflammation in a model of acute lung injury (ALI). In this work we analyzed effects therapeutic CBD mice subjected to lipopolysaccharide (LPS)-induced ALI on pulmonary mechanics and inflammation. (20 80 mg/kg) was administered (i.p.) 6 h after LPS-induced One day (24 h) induction assessment were analyzed. The results show decreased total resistance elastance, leukocyte migration into lungs,...
Summary Background A number of clinical studies have documented both a pro‐ and anti‐inflammatory role for sex hormones in the context lung inflammation worsening asthma. Objective To determine murine model allergic airway hyper‐responsiveness (AHR) induced by ovalbumin (OVA). Methods Female BALB/c were sensitized to OVA on days 0 7 subsequently challenged day 14 over 3‐day period. Mice had their ovaries removed either before or 8 after first injection 0. Pulmonary eosinophilia AHR measured...
Inhaled bacterial lipopolysaccharides (LPSs) induce an acute tumour necrosis factor-alpha (TNF- α -) dependent inflammatory response in the murine airways mediated by Toll-like receptor 4 (TLR4) via myeloid differentiation MyD88 adaptor protein pathway. However, contractile of bronchial smooth muscle and role endogenous TNF this process have been elusive. We determined vivo respiratory pattern C57BL/6 mice after intranasal LPS administration with or without presence increasing doses...
Introduction: It has been shown that the innate immune system mediates acute lung inflammation triggered by intestinal trauma. Sexual dimorphism modulates profile of TH1 and TH2 lymphocytes, accordingly sex hormones may modulate ischemia/reperfusion (I/R). Studies indicate female rats are relatively resistant to organ injury caused hemorrhagic shock gut is more than male deleterious effects ischemic injury. At present study, we investigated effect estradiol (E2) on after I/R its interaction...
Asthma is a chronic inflammatory disease that affects more females than males after puberty, and its symptoms severity in women change during menstruation menopause. Recently, evidence has demonstrated interactions among the microbiota, female sex hormones, immunity are associated with development of autoimmune diseases. However, no studies have investigated if therapeutic gut microbiota modulation strategies could affect asthma exacerbation Here we aimed to examine preventive effects...
Intestinal ischemia/reperfusion (IR) injury is a serious and triggering event in the development of remote organ dysfunction, from which lung main target. This condition characterized by intense neutrophil recruitment, increased microvascular permeability. IR also responsible for induction adult respiratory distress syndrome, most life-threatening form acute injury. The purpose this study was to investigate effect annexin-A1 protein as an endogenous regulator induced intestinal...
Fluctuations of estradiol and progesterone levels caused by the menstrual cycle worsen asthma symptoms. Conflicting data are reported in literature regarding pro anti-inflammatory properties progesterone. Female Wistar rats were ovalbumin (OVA) sensitized 1 day after resection ovaries (OVx). Control group consisted sensitized-rats with intact (Sham-OVx). Allergic challenge was performed aerosol (OVA 1%, 15 min) two weeks later. Twenty four hours challenge, BAL, bone marrow total blood cells...
Abstract The phenotypes of allergic airway diseases are influenced by the interplay between host genetics and gut microbiota, which may be modulated probiotics. We investigated probiotic effects on inflammation in A/J C57BL/6 mice. mice had increased microbiota diversity compared to at baseline . Acetate producer probiotics differentially altered genus abundance specific bacteria, such as Akkermansia Allistipes , mouse strains. induced followed treatment found that only exhibited decreased...
Intestinal ischemia followed by reperfusion (I/R) may occur following intestinal obstruction. In rats, I/R in the small intestine leads to structural changes accompanied neuronal death.The objective was analyze impact of injury on different populations myenteric plexus rat ileum after periods reperfusion.The superior mesentery artery occluded for 45 minutes, and animals were euthanized 24 hours 1 week reperfusion. Immunohistochemical analyses performed with antibodies against P2X2 receptor...
Abstract Recent studies have highlighted the influence of fetal/maternal interactions on development asthma. Because IFN-γ reduces Th2-mediated allergic responses, we assessed its capacity to modulate asthma in offspring when injected into mothers during pregnancy. was CD1 female mice day 6.5 gestation. Immediately after birth, male newborns were housed cages with interchanged mothers: from IFN-γ-treated breastfed by normal (IFN/nor), and those (Nor/IFN) or (Nor/nor). weaning, spleen cells...
Summary Background Airway remodelling encompasses the structural changes observed in asthmatic airways. Mast cells, through release of histamine and 5‐hydroxytryptamine (serotonin), are implicated early reactions, bronchoconstriction mucosal oedema, development bronchial hyperresponsiveness. However, association between serotonin processes murine model airways inflammation remains to be elucidated. Objective As is released by mast cells upon antigen challenge, we tested hypothesis its...