A5038686248- Cancer, Lipids, and Metabolism
- Synthesis and Reactions of Organic Compounds
- Synthesis of heterocyclic compounds
- Oxidative Organic Chemistry Reactions
- Synthesis and Characterization of Heterocyclic Compounds
- Cancer Treatment and Pharmacology
- Organoselenium and organotellurium chemistry
- Nanoparticle-Based Drug Delivery
- Curcumin's Biomedical Applications
- Drug Transport and Resistance Mechanisms
- Catalytic Alkyne Reactions
- Prostate Cancer Treatment and Research
- Sulfur-Based Synthesis Techniques
- Synthesis and biological activity
- Asymmetric Synthesis and Catalysis
- Gut microbiota and health
- Chemotherapy-induced cardiotoxicity and mitigation
- Organic Chemistry Cycloaddition Reactions
- Vanadium and Halogenation Chemistry
- Multiple Myeloma Research and Treatments
- Chemical synthesis and pharmacological studies
- Fluorine in Organic Chemistry
- Dental materials and restorations
- Cyclopropane Reaction Mechanisms
- Organic and Inorganic Chemical Reactions
Anhanguera-Uniderp University
2015-2017
Universidade de São Paulo
1997-2016
Anhanguera (Brazil)
2013
Hospital Bandeirantes
2008
Instituto Butantan
2008
Hospital São Paulo
2003-2006
Instituto de Ciências Farmacêuticas
2002
Universidade Federal de Santa Maria
1997-1999
Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal microbiota and have anti-inflammatory histone deacetylase–inhibiting properties. Recently, a dual relationship between intestine kidneys has been unraveled. Therefore, we evaluated role of SCFA in an AKI model which inflammatory process detrimental role. We observed that therapy with three main SCFAs (acetate, propionate, butyrate) improved renal dysfunction caused injury. This protection was associated...
A cholesterol-rich microemulsion (LDE) that binds to low-density lipoprotein (LDL) receptors is selectively taken up by malignant cells overexpress those and may be used as vehicle for antineoplastic agents. This study aimed develop the association of etoposide with LDE. It was firstly observed poorly associates microemulsion, therefore experiments were performed a lipophilic fatty acid derivative drug. The oleate LDE almost 100% tested physical chemical stability, well cellular uptake,...
Asthma is a chronic inflammatory disease that affects more females than males after puberty, and its symptoms severity in women change during menstruation menopause. Recently, evidence has demonstrated interactions among the microbiota, female sex hormones, immunity are associated with development of autoimmune diseases. However, no studies have investigated if therapeutic gut microbiota modulation strategies could affect asthma exacerbation Here we aimed to examine preventive effects...
Abstract A cholesterol-rich nanoemulsion (LDE) may be used as a vehicle to target antineoplastic drugs against cancer cells. The association of an etoposide derivative LDE is stable and retains the cytotoxic activity etoposide. We have evaluated toxicity antitumoral action this new preparation in-vivo. Melanoma-bearing mice control were administered LDE-etoposide oleate or commercial etoposide, either with without radioactive labelling. maximum tolerated dose (MTD), tissue distribution,...
Abstract A lipidic nanoemulsion termed LDE concentrates in neoplastic cells after injection into the bloodstream and thus can be used as a drug carrier to tumour sites. The chemotherapeutic agent daunorubicin associates poorly with LDE; aim of this study was clarify whether derivatization by attachment an oleyl group increases association LDE, test cytotoxicity animal toxicity new preparation. oleyldaunorubicin (oDNR) showed high yield (93 ± 2% 84 4% at 1:10 1:5 drug:lipid mass,...
A lipidic nanoemulsion termed LDE concentrates in neoplastic cells after injection into the bloodstream and thus can be used as a drug carrier to tumour sites. The chemotherapeutic agent daunorubicin associates poorly with LDE; aim of this study was clarify whether derivatization by attachment an oleyl group increases association LDE, test cytotoxicity animal toxicity new preparation. oleyldaunorubicin (oDNR) showed high yield (93 ± 2% 84 4% at 1:10 1:5 drug:lipid mass, respectively) stable...
Abstract The reactivity of the β‐enamino ketones, 3‐amino‐1‐( p ‐phenyl‐substituted)‐2‐buten‐1‐ones 1a‐d and esters. Ethyl‐3‐amino‐3‐( ‐phenyl‐substituted)‐2‐propenoates 5a‐d were evaluated by systematic studies reactions with hydrazine methylhydrazine solid support K‐10/ultrasound homogeneous media (reflux in ethanol or dichloromethane) yielding pyrazole rings 2a‐d , N ‐methylpyrazoles 3a‐d, 4a‐d ‐methylpyrazolinones 6a‐c 7a‐c . regiochemistry cyclization showed dependence reaction...
Abstract The reactivity of the β‐enamino ketones, 3‐amino‐1‐( p ‐phenyl‐substituted)‐2‐buten‐1‐ones 1a‐d and esters, ethyl 3‐amino‐3‐( ‐phenyl‐substituted)‐2‐propenoates 5a‐d was systematically studied when allowed to react with hydrazine methylhydrazine under solid support K ‐10/ultrasound conditions in homogeneous media (reflux ethanol or dichloromethane). products were pyrazoles 2a‐d , N ‐methylpyrazoles 3a‐d, 4a‐d N‐methylpyrazolinones 6a‐c 7a‐c . regiochemistry cyclization reactions...
Abstract The condensation of 4‐phenyl substituted β‐enamino ketones 1a‐d and esters 5a‐d with hydroxylamine hydrochloride using K‐10 as the solid support under sonication was studied to evaluate formation isoxazole 5‐isoxazolone rings from compounds a aromatic ring. Isoxazoles 2a‐c, 3c‐d 5‐isoxazolones 6a‐c 7a‐d were obtained. use K‐10/ultrasound in this reaction furnished novel results some cases.
Abstract Vinylic tellurides were synthesized by the addition of organotellurols to acetylenic alcohols and regioselectivity reaction was evaluated.
Abstract A facile method for the synthesis of substituted 3‐(2‐furylidene)‐2‐furanones has been developed using cyclofunctionalization reactions 2,4‐dialkenyl‐1,3‐dicarbonyl compounds and iodine as electrophile in presence Na 2 CO 3 , refluxing chloroform. Compounds 4 are obtained modest to good yields their structural identification was established by 1 H NMR, COSY, 13 C NMR H‐ COSY. mechanism proposed rationalize formation ylidene furanone.