A5061343114- DNA Repair Mechanisms
- Extracellular vesicles in disease
- Air Quality and Health Impacts
- MicroRNA in disease regulation
- Carcinogens and Genotoxicity Assessment
- Child Abuse and Trauma
- Skin Protection and Aging
- Genetics and Neurodevelopmental Disorders
- Epigenetics and DNA Methylation
- CRISPR and Genetic Engineering
- Adipose Tissue and Metabolism
- Maternal Mental Health During Pregnancy and Postpartum
- bioluminescence and chemiluminescence research
- Preterm Birth and Chorioamnionitis
- Genomics, phytochemicals, and oxidative stress
- Plant Pathogens and Fungal Diseases
- Photodynamic Therapy Research Studies
- Energy and Environment Impacts
- Immune cells in cancer
- COVID-19 impact on air quality
- Redox biology and oxidative stress
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Climate Change Communication and Perception
- Science and Education Research
- Plant pathogens and resistance mechanisms
Universidade Federal de São Paulo
2023-2024
Universidade de São Paulo
2016-2024
Universidade Federal de Ouro Preto
2020-2022
Harvard University
2018-2021
Cancer is a leading cause of death worldwide, and while great advances have been made particularly in chemotherapy, many types cancer still present dismal prognosis. In the case glioma, temozolomide (TMZ) main option for treatment, but it has limited success due to drug resistance. While this resistance usually associated DNA repair mechanisms, work we demonstrate that oxidative stress plays an important role. We showed upon TMZ treatment there induction nuclear factor erythroid 2-related 2...
Most of the studies on air pollution focus emissions from fossil fuel burning in urban centers. However, approximately half world's population is exposed to caused by biomass emissions. In Brazilian Amazon population, over 10 million people are directly high levels pollutants resulting deforestation and agricultural fires. This work first study present an integrated view effects inhalable particles burning. Exposing human lung cells particulate matter smaller than µm (PM
Air pollution represents a considerable threat to health worldwide. The São Paulo Metropolitan area, in Brazil, has unique composition of atmospheric pollutants with population nearly 20 million people and 9 passenger cars. It is long known that exposure particulate matter less than 2.5 µm (PM2.5) can cause various effects such as DNA damage. One the most versatile defense mechanisms against accumulation damage nucleotide excision repair (NER), which includes XPC protein. However, by NER...
Hypertriglyceridemia is an independent risk factor for cardiovascular disease. Dietary interventions based on protein restriction (PR) reduce circulating triglycerides (TGs), but underlying mechanisms and clinical relevance remain unclear. Here, we show that 1 week of a protein-free diet without enforced calorie significantly lowered TGs in both lean diet-induced obese mice. Mechanistically, the TG-lowering effect PR was due, part, to changes very low-density lipoprotein (VLDL) metabolism...
The striking and complex phenotype of Cockayne syndrome (CS) patients combines progeria-like features with developmental deficits. Since the establishment in vitro culture skin fibroblasts derived from CS 1970s, significant progress has been made understanding genetic alterations associated disease their impact on molecular, cellular, organismal functions. In this review, we provide a historic perspective research into by revisiting seminal papers field. We highlighted great contributions...
Ultraviolet (UV) radiation is one of the most genotoxic, universal agents present in environment. UVB (280-315 nm) directly damages DNA, producing cyclobutane pyrimidine dimers (CPDs) and 6-4 pyrimidone photoproducts (6-4PPs). These photolesions interfere with essential cellular processes by blocking transcription replication polymerases, may induce skin inflammation, hyperplasia cell death eventually contributing to aging, effects mediated mainly keratinocytes. Additionally, these lesions...
Sunlight ultraviolet (UV) radiation constitutes an important environmental genotoxic agent that organisms are exposed to, as it can damage DNA directly, generating pyrimidine dimers, and indirectly, oxidized bases single-strand breaks (SSBs). These lesions lead to mutations, triggering skin eye disorders, including carcinogenesis photoaging. Stratospheric ozone layer depletion, particularly in the Antarctic continent, predicts uncertain scenario of UV incidence on Earth next decades. This...
DUOX1 is an H 2 O ‐generating enzyme related to a wide range of biological features, such as hormone synthesis, host defense, cellular proliferation, and fertilization. frequently downregulated in lung liver cancers, suggesting tumor suppressor role for this enzyme. Here, we show that expression decreased breast cancer cell lines also cancers when compared the nontumor counterpart. In order address cells, stably knocked down mammary cells (MCF12A) with shRNA. This led higher proliferation...
Aging | doi:10.18632/aging.203617. Gustavo Satoru Kajitani, Lear Brace, Jose Humberto Trevino-Villarreal, Kaspar Trocha, Michael Robert MacArthur, Sarah Vose, Dorathy Vargas, Roderick Bronson, Jayne Mitchell, Carlos Frederico Martins Menck, James Mitchell
Childhood maltreatment (CM) may affect not only directly exposed individuals but also their offspring. However, the underlying biological mechanisms remain unclear. microRNAs (miRNAs) play a regulatory role in this process. This study investigates relationship between maternal exposure to CM and miRNA expression perinatal tissues.
<title>Abstract</title> Traumatic brain injury (TBI) is a prevalent and debilitating condition, which often leads to the development of post-traumatic epilepsy (PTE), condition that yet lacks preventive strategies. Biperiden, an anticholinergic drug, promising candidate has shown efficacy in murine models PTE. MicroRNAs (miRNAs), small regulatory RNAs, can help understanding biological basis PTE, act as TBI- PTE-relevant biomarkers be detected peripherally, they are present extracellular...
“Se você é jovem ainda, amanhã velho será. A menos que o coração sustente a juventude, nunca morrerá”. É assim Roberto Gómez Bolaños, mais conhecido no Brasil pelo seu personagem “Chaves”, começa sua canção sobre como encarar envelhecimento humano. um conceito foi interpretado e reinterpretado durante história diversos pontos de vista, artístico, filosófico, psicológico, biológico. Apesar da grande idade do envelhecimento, os fatores contribuem para biológico ainda estão sob discussão...
A elucidação da estrutura molécula de DNA foi uma das maiores conquistas Biologia no século XX. integridade dupla-hélice pode ser afetada por agentes internos ou externos que promovem lesões DNA, as quais podem bloquear a transcrição e replicação do DNA. Devido à sua importância, esses processos envolvendo o estão sujeitos fina regulação etapas correção erros, visam garantir qualidade fidelidade informação copiada transcrita cada passo pois, células possuem mecanismos reparo tolerância...