A5013837021- Carcinogens and Genotoxicity Assessment
- Air Quality and Health Impacts
- Toxic Organic Pollutants Impact
- Environmental Toxicology and Ecotoxicology
- Energy and Environment Impacts
- Bone Tissue Engineering Materials
- Microbial Metabolism and Applications
- Zebrafish Biomedical Research Applications
- Enzyme Production and Characterization
- Plant tissue culture and regeneration
- Seaweed-derived Bioactive Compounds
- Mesenchymal stem cell research
- Marine Biology and Environmental Chemistry
- Tissue Engineering and Regenerative Medicine
- Aquaculture disease management and microbiota
- Essential Oils and Antimicrobial Activity
- DNA Repair Mechanisms
- Nanoparticles: synthesis and applications
- Marine and coastal plant biology
- Telomeres, Telomerase, and Senescence
- Radioactivity and Radon Measurements
- Genetics, Aging, and Longevity in Model Organisms
- Algal biology and biofuel production
- Microbial infections and disease research
- Head and Neck Cancer Studies
Universidade Federal do Rio Grande do Norte
2016-2025
Brazilian Agricultural Research Corporation
2023
Universidade Federal do Rio Grande
2021-2023
University of Lausanne
1989-2005
This work reports the results of analyses three complete mycoplasma genomes, a pathogenic (7448) and nonpathogenic (J) strain swine pathogen Mycoplasma hyopneumoniae avian synoviae; genome sizes strains were 920,079 bp, 897,405 799,476 respectively. These genomes compared with other sequenced reported in literature to examine several aspects evolution. Strain-specific regions, including integrative conjugal elements, rearrangements alterations adhesin sequences observed M. strains, all these...
Chromobacterium violaceum is one of millions species free-living microorganisms that populate the soil and water in extant areas tropical biodiversity around world. Its complete genome sequence reveals ( i ) extensive alternative pathways for energy generation, ii ≈500 ORFs transport-related proteins, iii complex systems stress adaptation motility, iv widespread utilization quorum sensing control inducible systems, all which underpin versatility adaptability organism. The also contains but...
The Brazilian Amazon represents about 40% of the world's remaining tropical rainforest. However, human activities have become important drivers disturbance in that region. majority forest fire hotspots arc due to deforestation are impacting health local population over 10 million inhabitants. In this study we characterize western Amazonia biomass burning emissions through quantification 14 Polycyclic Aromatic Hydrocarbons (PAHs), Organic Carbon, Elemental Carbon and unique tracers such as...
Most of the studies on air pollution focus emissions from fossil fuel burning in urban centers. However, approximately half world's population is exposed to caused by biomass emissions. In Brazilian Amazon population, over 10 million people are directly high levels pollutants resulting deforestation and agricultural fires. This work first study present an integrated view effects inhalable particles burning. Exposing human lung cells particulate matter smaller than µm (PM
Diflubenzuron (DFB) and pyriproxyfen (PPF) are larvicides used in crops to control insect plagues. However, these pesticides known impact non-target organisms like fish mammals. Here, we aimed at assessing the embryotoxicity of purified DFB, PPF, their mixtures a organism—zebrafish. Zebrafish embryos were exposed different concentrations for 120 h: 0.025, 0.125, 0.25, 1.25, 2.5, 10 mg/L PPF while 0.025 + DFB (Mix A), 0.125 B), 0.25 C) DFB. We observed mortality, teratogenicity,...
Abstract Background The scorpion Tityus stigmurus is widely distributed in Northeastern Brazil and known to cause severe human envenoming, inducing pain, hyposthesia, edema, erythema, paresthesia, headaches vomiting. present study uses a transcriptomic approach characterize the gene expression profile from non-stimulated venom gland of scorpion. Results A cDNA library was constructed 540 clones were sequenced grouped into 153 clusters, with one or more ESTs (expressed sequence tags)....
In this study, the onion (Allium cepa) root test was used to evaluate genotoxicity of Pitimbu River (Natal city, Brazil) surface water. The water collected at five sampling sites along river and one sample obtained after treatment (flocculation, chlorination pH correction) for human consumption. All raw samples increased frequency chromosomal abnormalities and/or micronuclei two produced alterations in mitotic index cells. Two also altered growth morphological modifications A. cepa roots....
The Amazon represents an area of 61% Brazilian territory and is undergoing major changes resulting from disorderly economic development, especially the advance agribusiness. Composition atmosphere controlled by several natural anthropogenic processes, emission biomass burning one with impact on human health. aim this study was to evaluate genotoxic potential air pollutants generated through micronucleus assay in exfoliated buccal cells schoolchildren region. conducted during dry seasons two...
Abstract: This article reports the genotoxicity assessment of an extract M. oleifera seed powder and water‐soluble Moringa lectin (WSMoL) isolated from seeds. The by chitin chromatography showed hemagglutinating activity with different erythrocytes, in a broad pH range (4.5 to 9.5), retention after being heated 100 °C. Genotoxicity WSMoL were assessed using cell‐free plasmid DNA as well Salmonella typhimurium (Ames Kado) assays TA97, TA98, TA100, TA102 presence or absence hepatic...
Violacein is a purple pigment from Chromobacterium violaceum that possesses diverse biological and pharmacological properties. Among these, pro-oxidant antioxidant activities have been suggested. However, the cytotoxic mechanisms induced by violacein are poorly understood improvement in knowledge regarding these cell death will be useful to develop new therapeutic approaches. Considering this, our work, we investigated effects of non-tumor (CHO-K1 MRC-5) tumor (HeLa) lines, searching for...
Two distinct, TATA box-containing promoters regulate the transcriptional activity of Xenopusvitellogenin A1 gene. These two are different strength and separated by 1.8 kilobase pairs untranslated sequence. Estrogen receptor (ER) its ligand, 17β-estradiol, induce both promoters. The estrogen response elements (EREs) located proximal to downstream i promoter while no ERE-like sequences have been identified in vicinity upstreamio promoter. We show here, that upstream io is Sp1-dependent....
Abstract An extract (decoction) from pepper tree stem bark ( Schinus terebinthifolius Raddi) is widely used in Brazil as a topical antiinflammatory agent and to cicatrize wounds. The contains catechin, tannins, terpenes, flavonoids, saponins; of these components, both mutagenic potential antioxidant properties have been ascribed flavonoids. mutagenicity some flavonoids believed be associated with the formation reactive oxygen species seems depend on number position hydroxyl groups. In...
Retene (RET) is the most abundant polycyclic aromatic hydrocarbon (PAH) released upon burning of cellulose, although it not considered as one priority PAHs and included for risk assessments by US Environmental Protection Agency (US-EPA). There are only a few studies concerning toxic effects RET. To best our knowledge, this study first to examine whether RET, in an environmental concentration, plays crucial role induction oxidative stress A549 lung cell line, its consequence such mutagenicity...
Titanium (Ti) is currently the most widely used material for manufacture of orthopedic and dental implants. Changes in surface commercial pure Ti (cp Ti) can determine functional response cells, therefore a critical factor success implant. However, genotoxicity titanium surfaces has been poorly studied. Thus, purpose this study was to evaluate genotoxic potential new developed by plasma treatment using argon-ion bombardment compare it with an untreated surface. Accordingly, comet assay,...
Fucan is a term used to denominate family of sulfated polysaccharides rich in L-fucose. They are extracted mainly from brown seaweeds and echinoderms. The seaweed Spatoglossum schröederi (Dictyotaceae) synthesizes three heterofucans named A, B C. Our research group purified non-anticoagulant heterofucan (fucan A) which displays antithrombotic activity vivo. However, its vitro toxicity has yet be determined. This work presents the evaluation potential cytotoxicity, mutagenicity genotoxicity...