A5050009753- Research on Leishmaniasis Studies
- Trypanosoma species research and implications
- Mosquito-borne diseases and control
- Synthesis and Biological Evaluation
- Immune Cell Function and Interaction
- Autoimmune and Inflammatory Disorders Research
- Viral Infections and Vectors
- COVID-19 Clinical Research Studies
- Tuberculosis Research and Epidemiology
- Insect Pest Control Strategies
- SARS-CoV-2 and COVID-19 Research
- Synthesis and biological activity
- HIV Research and Treatment
- Pneumocystis jirovecii pneumonia detection and treatment
- Galectins and Cancer Biology
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Long-Term Effects of COVID-19
- Crystallization and Solubility Studies
- Traditional and Medicinal Uses of Annonaceae
- X-ray Diffraction in Crystallography
- Immune cells in cancer
- Paraoxonase enzyme and polymorphisms
- Malaria Research and Control
- Bioactive Compounds and Antitumor Agents
- Leprosy Research and Treatment
Universidade Federal da Paraíba
2016-2025
Universidade Federal do Rio Grande do Norte
2011-2024
Discovery Air (Canada)
2020
Universidade Estadual da Paraíba
2019
Universidade Federal de Minas Gerais
2008-2013
Santa Casa Hospital
2011
Violacein is a purple pigment from Chromobacterium violaceum that possesses diverse biological and pharmacological properties. Among these, pro-oxidant antioxidant activities have been suggested. However, the cytotoxic mechanisms induced by violacein are poorly understood improvement in knowledge regarding these cell death will be useful to develop new therapeutic approaches. Considering this, our work, we investigated effects of non-tumor (CHO-K1 MRC-5) tumor (HeLa) lines, searching for...
Background. Leprosy morbidity is increased by 2 pathologic immune reactions, reversal reaction (RR) and erythema nodosum leprosum (ENL).
Leishmaniasis is a neglected tropical infectious disease with thousands of cases annually; it great concern to global health, particularly the most severe form, visceral leishmaniasis. Visceral leishmaniasis treatments are minimal and have adverse effects. As guanidine-bearing compounds shown antimicrobial activity, we analyzed cytotoxic effects several on Leishmania infantum in their promastigote amastigote forms vitro, cytotoxicity human cells, impact reactive nitrogen species production....
Visceral leishmaniasis (VL) is a neglected parasitic disease, and the first‐line treatments for VL include drugs that exhibit serious toxicological issues. In this sense, new molecules are sought treatment, such as Carvacrol (Car), phenolic monoterpene has shown strong activity against Leishmania spp. However, its low solubility prevents free administration, requiring therapeutic strategy encapsulation in chitosan biopolymeric nanoparticles. This study aimed to develop nanoparticles (NPChi)...
The aim of the present study was to investigate TLR2 expression in peripheral blood monocytes from dogs naturally infected with Leishmania (Leishmania) infantum determine whether it correlates CD11b/CD18 (CR3) expression, and evaluate potential as sources infection using phlebotomine xenodiagnosis. Forty eight were serologically diagnosed L. by indirect immunofluorescence antibody test (IFAT) enzyme linked immunosorbent assay (ELISA). Parasitological exams bone-marrow aspirates positive PCR...
Leishmaniasis is an important tropical disease composed of several clinical forms that adversely affect millions people globally. Critical cells involved in the host-Leishmania interaction are monocytes and macrophages, which act to protect against infections due their ability both control intracellular regulate subsequent adaptive immune response. Both soluble factors cell surface receptors keys directing response following with pathogens such as Leishmania. Toll-like (TLRs) have essential...
Carcinoma of the uterine cervix is second most common female tumor worldwide, surpassed only by breast cancer. Natural products from seaweeds evidencing apoptotic activity have attracted a great deal attention as new leads for alternative and complementary preventive or therapeutic anticancer agents. Here, methanol extracts 13 species tropical (Rhodophytas, Phaeophyta Chlorophyta) collected Northeast Brazil were assessed apoptosis-inducing agents on human cervical adenocarcinoma (HeLa). All...
Leishmaniasis is a complex infectious parasitic disease caused by protozoa of the genus Leishmania, belonging to group neglected tropical diseases. It poses significant global health challenges, particularly in socio-economically disadvantaged regions. Macrophages, as innate immune cells, play crucial role initiating inflammatory response against pathogens responsible for this disease. Macrophage polarization, process differentiating macrophages into pro-inflammatory (M1) or...
Vitamin A supplementation has shown to prevent mortality by diarrheal and respiratory diseases in several countries. Nevertheless, there are few studies investigating the effect of vitamin visceral leishmaniasis (VL), although reports its deficiency children with symptomatic VL Brazil Bangladesh. This study analyzed on a subset Treg cells monocytes isolated from healthy residing an endemic area for Northeast Brazil. Serum retinol concentrations correlated inversely IL-10 TGF-β productions...
Leishmaniasis represents a series of severe neglected tropical diseases caused by protozoa the genus Leishmania and is widely distributed around world. Here, we present syntheses Morita-Baylis-Hillman adducts (MBHAs) prepared from eugenol, thymol carvacrol, their bioevaluation against promastigotes amazonensis. The new MBHAs are in two steps essential oils moderate to good yields IC50 values range 22.30-4.71 μM. Moreover, selectivity index most potent compound very high (SIrb > 84.92), far...
There is a need for more detailed elucidation of T-cell immunity in chikungunya infection. CD8 T cells are one main actors against viruses. Here, we analysed CD8+ lymphocytes from patients the acute and chronic phases disease (CHIKD). Our results demonstrate that expressed higher ex vivo granzyme B, perforin CD107A expression phase CHIKD compared with healthy individuals CD69, interleukin-17A, interleukin-10 CD95 ligand, co-expression CD95/CD95 ligand. These elucidate importance these...
Leishmania infantum is the etiological agent of visceral leishmaniasis (VL) in South America, Mediterranean basin, and West Central Asia. The most affected country, Brazil, reported 4297 VL cases 2017. L. transmitted by female phlebotomine sand flies during successive blood meals. There are no validated vaccines to prevent infection treatment relies on drugs that often present severe side effects, which justify efforts find new antileishmanial drugs. Cinnamic acid derivatives have shown...