A5056257730- Epigenetics and DNA Methylation
- Pancreatic and Hepatic Oncology Research
- Cancer Genomics and Diagnostics
- Cancer Research and Treatments
- Cancer Immunotherapy and Biomarkers
- Genetic factors in colorectal cancer
- Posttraumatic Stress Disorder Research
- Genomics and Phylogenetic Studies
- Bioinformatics and Genomic Networks
- Genomics and Chromatin Dynamics
- Policing Practices and Perceptions
- Evolution and Genetic Dynamics
- Cancer-related molecular mechanisms research
- Chromosomal and Genetic Variations
- Resilience and Mental Health
- Migration, Health and Trauma
- RNA modifications and cancer
- Renal cell carcinoma treatment
- DNA Repair Mechanisms
- Genomics and Rare Diseases
- Traumatic Brain Injury Research
- Memory and Neural Mechanisms
- Genetics, Bioinformatics, and Biomedical Research
- Nutrition, Genetics, and Disease
- Spatial Cognition and Navigation
University of Cambridge
2003-2024
Ontario Institute for Cancer Research
2014-2023
Weatherford College
2022
Northwestern University
2020
Dana-Farber Cancer Institute
2019
Harvard University
2019
University Health Network
2019
Toronto General Hospital
2019
Bournemouth University
2014-2017
Microsoft (United States)
2012-2014
Purpose: To perform real-time whole genome sequencing (WGS) and RNA (RNASeq) of advanced pancreatic ductal adenocarcinoma (PDAC) to identify predictive mutational transcriptional features for better treatment selection.Experimental Design: Patients with PDAC were prospectively recruited prior first-line combination chemotherapy. Fresh tumor tissue was acquired by image-guided percutaneous core biopsy WGS RNASeq. Laser capture microdissection performed all cases. Primary endpoint feasibility...
Abstract Purpose: To determine the impact of basal-like and classical subtypes in advanced pancreatic ductal adenocarcinoma (PDAC) to explore GATA6 expression as a surrogate biomarker. Experimental Design: Within COMPASS trial, patients proceeding chemotherapy for PDAC undergo tumor biopsy RNA-sequencing (RNA-seq). Overall response rate (ORR) overall survival (OS) were stratified by according received. Correlation with using gene profiling, situ hybridization (ISH) was explored. Results:...
We report on the value sensitive design, development, and appropriation of a groupware system to support software engineering knowledge sharing. Usage data (5,965 visitors) semi-structured interviews (18 individuals) suggest methods employed were successful in addressing tensions, particularly with respect privacy, awareness, reputation. Key contributions include: (1) "proof-of-concept" that established Value Sensitive Design principles can be used good effect for design an industry setting,...
Colorectal cancer (CRC) is a biologically heterogeneous disease. To characterize its mutational profile, we conduct targeted sequencing of 205 genes for 2,105 CRC cases with survival data. Our data shows several findings in addition to enhancing the existing knowledge CRC. We identify PRKCI, SPZ1, MUTYH, MAP2K4, FETUB, and TGFBR2 as additional significantly mutated find that among hypermutated tumors, an increased mutation burden associated improved CRC-specific (HR = 0.42, 95% CI:...
The design, development, and deployment of interactive systems can substantively impact individuals, society, the natural environment, now potentially well into future. Yet, a scarcity methods exists to support long-term, emergent, systemic thinking in design practice. Toward addressing this gap, we propose four envisioning criteria --- stakeholders, time, values, pervasiveness -- distilled from prior work urban planning, noir, Value Sensitive Design. We characterize how thinking, illustrate...
Abstract Background We investigated work-related exposure to stressful and traumatic events in police officers, including repeated materials, predicted that ICD-11 complex PTSD (CPTSD) would be more prevalent than posttraumatic stress disorder (PTSD). The effects of demographic variables on were examined, along with whether specific types uniquely associated or CPTSD. Methods An online survey covering issues about trauma management, wellbeing working conditions was disseminated via social...
A recurring historic finding in cancer drug development is encouraging antitumor effects observed tumor-bearing mice that fail to translate into the clinic. An intriguing exception this pattern immune checkpoint therapy, as sustained tumor regressions subsets of patients are rare mice. Reasoning may be due part relatively low mutational loads mouse tumors, we mutagenized transplantable cell lines EMT-6/P, B16F1, RENCA, CT26, and MC38 vitro with methylnitro-nitrosoguanidine (MNNG) or...
One in five UK police officers suffers from Post-Traumatic Stress Disorder or Complex Disorder, yet there is no gold standard measure of trauma exposure available. This study coded 4,987 exposures reported by 1,531 officers, using their own language. The resulting checklist describes over 70% typical ‘worst’ traumatic incidents (plus situational factors, including Covid19). Police Traumatic Experiences Checklist a practical tool value for self-assessment and peer support, can facilitate...
Web programming is increasing rapidly in importance at the university level, yet there no consensus about when and how it should be incorporated into computer science curriculum. This paper describes our results teaching an experimental introductory web course University of Washington that has had great success attracting large numbers students from inside outside major. The requires CS1 as a prerequisite, striking good balance between making open to non-majors but also more rigorous for...
Short tandem repeat (STR) analysis, such as the AmpFlSTR® Identifiler® Plus kit, is a standard, PCR-based human genotyping method used in field of forensics. Misidentification cell line and tissue DNA can be costly if not detected early; therefore it necessary to have quality control measures STR profiling place. A major issue large-scale research studies involving archival formalin-fixed paraffin embedded (FFPE) tissues that varying levels degradation result failure correctly identify...
The influence of genes and the environment on development Post-Traumatic Stress Disorder (PTSD) continues to motivate neuropsychological research, with one consistent focus being Brain-Derived Neurotrophic Factor (BDNF) gene, given its impact integrity hippocampal memory system. Research into human navigation also considers BDNF gene in relation dependent spatial processing. This speculative paper brings together trauma processing for first time presents exploratory research their...
Fatigue is one of the most common and debilitating symptoms multiple sclerosis (MS) main reason why people with MS stop working early. The Society in United Kingdom funded a randomized controlled trial FACETS-a face-to-face group-based fatigue management program for (pwMS)-developed by members research team. Given favorable results to help implementation, supported design printing FACETS manual materials national delivery training courses (designed team) health care professionals (HCPs). By...
Neuropsychological trauma processing techniques based on hippocampal-dependent spatial and episodic memory were trialled with 71 newly recruited officers within one UK police force between March 2018 February 2019. Results indicate that the skills are teachable an operational training environment, have a positive impact feelings of ease about difficult or traumatic work-related incidents, can improve recall events may mitigate against age exposure memory. Participants report to be useable,...
OPINION article Front. Hum. Neurosci., 26 February 2014Sec. Cognitive Neuroscience Volume 8 - 2014 | https://doi.org/10.3389/fnhum.2014.00100
Abstract It has been widely reported that surveys have found high levels of ICD-11 complex post-traumatic stress disorder (CPTSD) (12.6%) among police personnel, and a further 8.0% with PTSD. Until now, there little research linking PTSD to working conditions. This report examines how the prevalence CPTSD varies measures job quality. Positive indicators quality (for instance, feeling doing meaningful work, support from colleagues managers, work–life balance, security, promotion prospects)...
Enterprise software developers must regularly communicate with one another to obtain information and coordinate changes legacy code, but find it cumbersome complicated determine the most relevant expedient person contact. This becomes especially difficult when has transferred teams or changed their personal contact since contributing project. We conducted a year-long series of surveys interviews help us learn how, why, how often discover another. In response what we saw, designed, deployed,...
Abstract Programmers are increasingly interested in developing applications that can be used internationally. Part of the internationalization effort is ability to engineer use dates and times conform local calendars yet inter‐operate with other calendars, for instance between Gregorian Islamic calendars. $\tau$ Z AMAN a system provides natural language‐ calendar‐independent framework integrating multiple performs ‘runtime‐binding’ language support. A running dynamically loads support tables...