A5049162326- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Medical Imaging Techniques and Applications
- Lung Cancer Treatments and Mutations
- AI in cancer detection
- Cell Adhesion Molecules Research
- HER2/EGFR in Cancer Research
University of Toronto
2022-2024
Princess Margaret Cancer Centre
2024
University Health Network
2024
Ki-67 is a nuclear protein associated with proliferation, and strong potential biomarker in breast cancer, but not routinely measured current clinical management owing to lack of standardization. Digital image analysis (DIA) promising technology that could allow high-throughput There dearth data on the reliability as well intra- interalgorithmic variability different DIA methods. In this study, we scored compared set cancer cases which manually counted has already been demonstrated have...
Epidermal growth factor receptors (EGFR) are overexpressed in triple-negative breast cancer (TNBC) and an attractive target for the development of theranostic radiopharmaceuticals. We studied anti-EGFR panitumumab labeled with 111In (panitumumab-DOTA-111In) SPECT/CT imaging Meitner–Auger electron (MAE) radioimmunotherapy (RIT) TNBC. Panitumumab-DOTA-111In was bound, internalized, routed to nucleus MCF7, MDA-MB-231/Luc, MDA-MB-468 human (BC) cells dependent on EGFR expression level (1.5 ×...
Abstract Background: Glioblastoma (GBM), a notably aggressive brain cancer, presents significant treatment challenges due to its propensity for deep, diffuse infiltration into healthy tissue. This trait enables GBM resist and survive following surgery conventional adjuvant therapies. Emerging evidence suggests that signaling between stem cells (GSCs) may be instrumental in this invasive behavior. Our study aimed unravel the intricacies of these intercellular communication networks within...