A5044385376- Genetic factors in colorectal cancer
- Neuroendocrine Tumor Research Advances
- Sarcoma Diagnosis and Treatment
- Pancreatic and Hepatic Oncology Research
- Colorectal Cancer Screening and Detection
- Gastric Cancer Management and Outcomes
- Cell Adhesion Molecules Research
- Gastrointestinal disorders and treatments
- Gastrointestinal Tumor Research and Treatment
- Viral-associated cancers and disorders
- Colorectal and Anal Carcinomas
- Cancer-related Molecular Pathways
- Soft tissue tumor case studies
- Cancer Genomics and Diagnostics
- Lymphoma Diagnosis and Treatment
- Colorectal Cancer Surgical Treatments
- Tumors and Oncological Cases
- Cancer Diagnosis and Treatment
- Vascular Tumors and Angiosarcomas
- Neuroblastoma Research and Treatments
- Colorectal Cancer Treatments and Studies
- Ovarian cancer diagnosis and treatment
- Helicobacter pylori-related gastroenterology studies
- Chromatin Remodeling and Cancer
- Neurofibromatosis and Schwannoma Cases
University Health Network
2013-2025
University of Toronto
2011-2023
Fiona Stanley Hospital
2023
Diageo (Ireland)
2023
University Hospitals Sussex NHS Foundation Trust
2020-2021
Brighton Hospital
2020
Toronto General Hospital
2007-2019
Royal Perth Hospital
2016-2018
University of Oxford
1993-2015
John Radcliffe Hospital
1993-2015
Epithelial neuroendocrine tumors (NETs) have been the subject of much debate regarding their optimal classification. Although multiple systems nomenclature, grading, and staging proposed, none has achieved universal acceptance. To help define underlying common features these classification to identify minimal pathology data that should be reported ensure consistent clinical management reproducibility from therapeutic trials, a multidisciplinary team physicians interested in NETs was...
Polycystic kidney disease 1 (PKD1) is the major locus of common genetic disorder autosomal dominant polycystic disease. We have studied PKD1 mRNA, with an RNase protection assay, and found widespread expression in adult tissue, high levels brain moderate signal kidney. Expression protein, polycystin, was assessed using monoclonal antibodies to a recombinant protein containing C terminus molecule. In fetal kidney, staining restricted epithelial cells. developing nephron most prominent mature...
Immunohistochemistry (IHC) for mismatch repair (MMR) proteins is used to identify MMR status: being diffusely positive (intact/retained nuclear staining) or showing loss of tumour staining (MMR protein deficient). Four colonic adenocarcinomas and a gastric adenocarcinoma with associated dysplasia that displayed heterogenous IHC patterns in at least one the four were characterised by next-generation sequencing (NGS). In order examine potential molecular mechanism these patterns, respective...
Transcriptional analyses have identified several distinct molecular subtypes in pancreatic ductal adenocarcinoma (PDAC) that prognostic and potential therapeutic significance. However, to date, an indepth, clinicomorphological correlation of these has not been performed. We sought identify specific morphological patterns compare with known subtypes, interrogate their biological significance, furthermore reappraise the current grading system PDAC.We first assessed 86 primary,...
Aim: To describe an unusual human immunodeficiency virus (HIV)‐associated lymphoma in uncommon sites. Plasmablastic is a distinctive HIV‐associated tumour that was first described the jaws and oral cavity. Only two cases (stomach lung) have been documented extra‐oral Materials methods: Four were encountered HIV+ patients: three anorectal region one which nasal paranasal. The routinely processed immunohistochemistry performed on formalin‐fixed paraffin‐embedded tissue. Results: showed typical...
Mucoepidermoid carcinoma (MEC) is the most common salivary gland malignancy. Oncocytic MEC (OMEC) has been rarely reported with previous cases suggesting they are largely cystic low-grade neoplasms a favorable prognosis. The differential diagnosis of OMEC includes numerous oncocytic/"oncocytoid" neoplasms. Some benign while others aggressive. Recent evidence suggests that p63 reliable marker in conventional but not explored OMEC. We searched archives various institutions for examples to...
Abstract Wnt pathway deregulation is a common characteristic of many cancers. Only colorectal cancer predominantly harbours mutations in APC , whereas other types (hepatocellular carcinoma, solid pseudopapillary tumours the pancreas) have activating β‐catenin ( CTNNB 1) . We compared dynamics and potency vivo Within murine small intestine SI ), an mutation took much longer to achieve acquire crypt‐progenitor cell CPC ) phenotype than Apc or Gsk3 loss. colon, single was unable drive induce...