A5019804024- Genetic factors in colorectal cancer
- Parasites and Host Interactions
- Global Maternal and Child Health
- COVID-19 Clinical Research Studies
- Cytomegalovirus and herpesvirus research
- Antifungal resistance and susceptibility
- HIV/AIDS Research and Interventions
- Herpesvirus Infections and Treatments
- HIV Research and Treatment
- Colorectal Cancer Screening and Detection
- Coronary Artery Anomalies
- Kawasaki Disease and Coronary Complications
- Global Health Workforce Issues
- Diagnosis and Treatment of Venous Diseases
- Neurological Complications and Syndromes
- Parasite Biology and Host Interactions
- HIV/AIDS Impact and Responses
- Maternal and fetal healthcare
- Antibiotic Use and Resistance
- Central Venous Catheters and Hemodialysis
- Neuroendocrine Tumor Research Advances
- Sex work and related issues
- Blood Coagulation and Thrombosis Mechanisms
- Bacillus and Francisella bacterial research
- Respiratory Support and Mechanisms
Hospital for Tropical Diseases
2024-2025
University College London Hospitals NHS Foundation Trust
2024
University College London
2018-2024
Hospital for Tropical Diseases
2024
Imperial College London
2022
NIHR Imperial Biomedical Research Centre
2022
Kenya Medical Research Institute
2018-2021
University of London
2021
London School of Hygiene & Tropical Medicine
2021
University Hospital of Wales
2020
Fungal coinfection is a recognized complication of respiratory virus infections, increasing morbidity and mortality, but can be readily treated if diagnosed early. An number small studies describing aspergillosis in coronavirus disease 2019 (COVID-19) patients with severe distress are being reported, comprehensive data lacking. The aim this study was to determine the incidence, risk factors, impact invasive fungal adult COVID-19 distress.An evaluation national, multicenter, prospective...
Rationale: Fungal co-infection is a recognised complication of respiratory virus infections, increasing morbidity and mortality, but can be readily treated if diagnosed early. An number small studies describing aspergillosis in COVID-19 patients with severe distress are being reported, comprehensive data lacking.Objectives: To determine the incidence, risk factors impact invasive fungal disease adult distress.Methods: evaluation national, multi-centre, prospective cohort an enhanced testing...
Abstract Background Female genital schistosomiasis (FGS) is a neglected tropical gynaecological disease that affects millions of women in sub-Saharan Africa (SSA). FGS caused by Schistosoma haematobium , parasitic carcinogen involved the pathogenesis squamous cell carcinoma bladder. Cervical cancer incidence and mortality are highest SSA, where pre-cancerous cervical dysplasia often detected on screening with visual inspection acetic acid (VIA). There no studies evaluating association...
Abstract Background Female genital schistosomiasis (FGS), the manifestation of S. haematobium infection in women, results protean gynaecological symptoms and longer-term complications. FGS affects an estimated 75% women with haematobium, totalling 56 million mainly sub-Saharan Africa. With increasing migration, will be encountered more frequently non-endemic settings. Despite this, evaluation diagnosis management guidelines for these settings are lacking. Methods A retrospective case-notes...
Abstract Background Treatment of superficial venous reflux in addition to compression therapy accelerates leg ulcer healing and reduces recurrence. The aim this study was evaluate the costs cost-effectiveness early versus delayed endovenous treatment patients with ulcers. Methods This a within-trial cost-utility analysis 1-year time horizon using data from EVRA (Early Venous Reflux Ablation) trial. compared deferred ablation for truncal ulcer. outcome measure cost per quality-adjusted...
Abstract Background To report on the implementation and outcomes of a virtual ward established for management mpox during 2022 outbreak, we conducted 2-center, observational, cross-sectional study over 3-month period. Methods All patients aged ≥17 years with laboratory polymerase chain reaction–confirmed monkeypox virus managed between 14 May 15 August 2022, at Hospital Tropical Diseases University College London Hospitals National Health Service (NHS) Foundation Trust sexual health services...
Background Human cytomegalovirus (HCMV) can be managed by monitoring HCMV DNA in the blood and giving valganciclovir when viral load exceeds a defined value. We hypothesised that such pre-emptive therapy should occur earlier than standard 3000 genomes/ml (2520 IU/ml) seropositive donor transmitted virus to seronegative recipient (D+R-) following solid organ transplantation (SOT). Methods Our local protocol was changed so D+R- SOT patients commenced once exceeded 200 genomes/ml; 168 IU/ml...
Persistent fetal vasculature (PFV) is most often a condition of unknown cause. It represents persisting elements ocular vessels including the hyaloid arterial network. Protein C vitamin K-dependent serine protease, which regulates coagulation. Deficiency protein leads to prothrombotic state. We report case male infant born at 34 weeks gestation non-consanguineous parents. Ophthalmic examination found bilateral PFV, microphthalmia and vitreoretinal dysplasia. He also suffered renal vein...
Abstract Background Acute HIV infection (AHI) is the phase of immediately after acquisition, during which many patients develop symptoms and often seek healthcare. However, clinicians in sub-Saharan Africa are not currently taught about AHI. Methods This study pilot-tested a self-directed AHI training module among clinical officers (COs) coastal Kenya assessed knowledge gained challenges to instituting screening. The included four domains: definition importance recognition; screening...
<h3>Introduction</h3> Patient experience is a key aspect of endoscopy service quality. It Global Rating Scale (GRS) requirement to capture data on patient comfort. In our unit comfort scores are recorded by the endoscopist and nurse using Modified Gloucester (1=no discomfort 5=severe discomfort). Patients do not usually record score. We suspected there may be differences in assessment between these different groups, which affect value this quality indicator. <h3>Methods</h3> Comfort was...
Characteristics of confirmed urogenital Schistosoma haematobium infections and outcomes in non-endemic regions are scarce the literature there is a minimal evidence base for appropriate management this setting. Specific schistosomal urinary urological complications include risk hydronephrosis, renal impairment, malignant transformation. Therefore, approach to follow-up should be robust systematic. This retrospective case-note review all patients with S infection (defined as visible ova...
Cytomegalovirus (CMV) is an important opportunistic pathogen after transplantation. Some virological variation in transplant recipients explained by donor and recipient CMV serostatus, but not all. Circadian variability of herpesviruses has been described, so we investigated the effect time day transplantation on posttransplant viremia.We performed a retrospective analysis 1517 patients receiving liver or kidney allografts at single center from 2002 to 2018. All were given preemptive therapy...
<h3>Introduction</h3> The serrated pathway of colorectal carcinogenesis is a distinct and important leading to CpG island methylated phenotype (CIMP) carcinomas. These lesions are over-represented in interval cancers may explain the failure prevent right-sided cancer with colonoscopy. Hyperplastic polyps (HPs) left colon rarely transform whereas proximal adenomas (SSAs) have definite malignant potential notoriously difficult detect endoscopically. There still uncertainty surrounding...
Abstract Background: Female genital schistosomiasis (FGS) is a neglected tropical gynaecological disease that affects millions of women in sub-Saharan Africa (SSA). FGS caused by Schistosoma (S.) haematobium , parasitic carcinogen involved the pathogenesis squamous cell carcinoma bladder. Cervical cancer incidence and mortality are highest SSA, where pre-cancerous cervical dysplasia often detected on screening with visual inspection acetic acid (VIA). No studies have evaluated association...
<h3>Introduction</h3> The serrated colorectal carcinogenesis pathway is increasingly recognised as a distinct and important route to CpG island methylated phenotype (CIMP) carcinomas, yet comparatively little known about the molecular pathogenesis of these lesions. precursor lesions - hyperplastic polyps, are initiated by <i>BRAF</i> or <i>KRAS</i> mutations which initially induce proliferation but followed activation oncogene-induced senescence (OIS) pathways resulting in telomere...
Cytomegalovirus (CMV) infection causes significant morbidity after transplant. Patients can be stratified by donor and recipient CMV serostatus, but the phenotype remains variable. We hypothesized that some of this variability might explained circadian rhythms influenced time Virological, demographic transplant data were reviewed for liver kidney patients (n = 1,111) managed between 2002 2015 using pre-emptive therapy. Donor circulatory arrest reperfusion in split into four categories,...