A5014503580- Global Maternal and Child Health
- Parasites and Host Interactions
- HIV/AIDS Research and Interventions
- HIV-related health complications and treatments
- Global Health Workforce Issues
- Parasite Biology and Host Interactions
- HIV Research and Treatment
- Cervical Cancer and HPV Research
- Syphilis Diagnosis and Treatment
- Global Health and Surgery
- Reproductive tract infections research
- HIV/AIDS Impact and Responses
- HIV/AIDS drug development and treatment
- HIV/AIDS oral health manifestations
- Streptococcal Infections and Treatments
- Reproductive Health and Contraception
- Microbial infections and disease research
- Vaccine Coverage and Hesitancy
- Adolescent Sexual and Reproductive Health
- Hepatitis Viruses Studies and Epidemiology
- Immunodeficiency and Autoimmune Disorders
- Pneumocystis jirovecii pneumonia detection and treatment
- Infective Endocarditis Diagnosis and Management
- Reproductive System and Pregnancy
Stanford University
2010-2025
Veterans Health Administration
2023-2024
London School of Hygiene & Tropical Medicine
2020-2022
University of London
2021-2022
VA Palo Alto Health Care System
2022
Santa Clara Valley Medical Center
2011-2014
Stanford Medicine
2014
New York University
2010
Given the potentially causal association of female genital schistosomiasis (FGS) with HIV-1 infection, improved diagnostics are urgently needed to scale-up FGS surveillance. The BILHIV (bilharzia and HIV) study assessed performance home-based self-collection methods (cervical vaginal swabs) compared cervicovaginal lavage (CVL) for detection Schistosoma DNA by real-time polymerase chain reaction (PCR).
Abstract Background Female genital schistosomiasis (FGS) is a neglected tropical gynaecological disease that affects millions of women in sub-Saharan Africa (SSA). FGS caused by Schistosoma haematobium , parasitic carcinogen involved the pathogenesis squamous cell carcinoma bladder. Cervical cancer incidence and mortality are highest SSA, where pre-cancerous cervical dysplasia often detected on screening with visual inspection acetic acid (VIA). There no studies evaluating association...
Female genital schistosomiasis (FGS) is a neglected and disabling gynecological disease that can result from infection with the parasitic trematode Schistosoma haematobium. Accurate diagnosis of FGS crucial for effective case management, surveillance control. However, current methods morbidity assessment be inaccessible to those at need, labour intensive, costly unreliable. Molecular techniques such as PCR used reliably diagnose via detection DNA using cervicovaginal lavage (CVL) samples...
<ns4:p>Female genital schistosomiasis (FGS) can occur in <ns4:italic>S. haematobium</ns4:italic> infection and is caused by parasite egg deposition the tract. Confirming a diagnosis of FGS challenging due to lack diagnostic reference standard. A 2010 expert-led consensus meeting proposed visual inspection cervicovaginal mucosa as an adequate standard for diagnosis. The agreement expert human reviewers visual-FGS has not been previously described.</ns4:p><ns4:p> </ns4:p><ns4:p>...
<ns3:p>Female genital schistosomiasis (FGS) and male (MGS) are gender-specific manifestations of urogenital schistosomiasis. Morbidity is a consequence prolonged inflammation in the human tract caused by entrapped eggs waterborne parasite, <ns3:italic>Schistosoma (S.) haematobium.</ns3:italic> Both diseases affect sexual reproductive health (SRH) millions people globally, especially sub-Sahara Africa (SSA). Awareness knowledge these largely absent among affected communities healthcare...
Introduction Multiplathogen home-based self-sampling offers an opportunity to increase access screening and treatment in endemic settings with high coinfection prevalence of sexually transmitted (HIV, Trichomonas vaginalis (Tv), human papillomavirus (HPV)) non-sexually pathogens ( Schistosoma haematobium (Sh )). Chronic coinfections may lead disability (female genital schistosomiasis) death (cervical cancer). The Zipime-Weka-Schista (Do self-testing sister!) study aims evaluate the validity,...
Female genital schistosomiasis (FGS) and male (MGS) are gender-specific manifestations of urogenital schistosomiasis. Morbidity is a consequence prolonged inflammation in the human tract caused by entrapped eggs waterborne parasite,
We report the first case of adult meningitis confirmed to be due Streptococcus gallolyticus subsp. pasteurianus. Phenotypically reported as bovis biotype II/2, 16S rRNA sequencing revealed S. Because taxonomic uncertainties, pasteurianus may an underrecognized agent systemic infections.
HIV-1 infection disproportionately affects women in sub-Saharan Africa, where areas of high prevalence and Schistosoma haematobium endemicity largely overlap. Female genital schistosomiasis (FGS), an inflammatory disease caused by S. egg deposition the tract, has been associated with prevalent infection. Elevated levels chemokines MIP-1α (CCL-3), MIP-1β (CCL-4), IP-10 (CXCL-10), IL-8 (CXCL-8) cervicovaginal lavage (CVL) have acquisition. We hypothesize that cytokines may be raised FGS could...
<ns4:p><ns4:bold>Background: </ns4:bold>Female genital schistosomiasis (FGS) can occur in <ns4:italic>S. haematobium</ns4:italic> infection and is caused by egg deposition the tract. Confirming a diagnosis of FGS challenging due to lack diagnostic reference standard. A 2010 expert-led consensus meeting proposed visual inspection cervicovaginal mucosa as an adequate standard for diagnosis. The agreement expert human reviewers visual-FGS has not been previously described.</ns4:p><ns4:p>...
Treatment with highly active antiretroviral therapy (HAART) reduces overall perinatal human immunodeficiency virus (HIV) type 1-related mortality. The effect of timing HAART initiation on reduction morbidity is not well defined. We evaluated the association progression to moderate or severe disease.Retrospective, population-based study 196 perinatally HIV-infected children followed from birth in northern California 1988 2009.Of children, 58% received and were for a median 6.2 years after...
The cervicovaginal microbiota, including sexually transmitted infections (STIs), have not been well described in female genital schistosomiasis (FGS).Women (aged 18-31, active, nonpregnant) were invited to participate at the final follow-up of HPTN 071 (PopART) Population Cohort January-August 2018. We measured key species microbiota (Lactobacillus crispatus, L. iners, Gardnerella vaginalis, Atopobium vaginae, and Candida) STIs (Chlamydia trachomatis, Neisseria gonorrhoeae, Trichomonas...
ABSTRACT Introduction Multiplathogen home-based self-sampling offers an opportunity to increase access screening and treatment. Infections include sexually transmitted (HIV, Trichomonas vaginalis (Tv), human papillomavirus [HPV] for cervical precancer detection) non-sexually pathogens ( Schistosoma haematobium (Sh)) pathogens, in endemic settings with high co-infection prevalence. Chronic infection may lead disability (female genital schistosomiasis (FGS) death (cervical cancer). The...
<ns4:p><ns4:bold>Background</ns4:bold>: Female genital schistosomiasis (FGS) is a neglected and disabling gynaecological disorder that difficult to diagnose part of the wider spectrum urogenital disease caused by waterborne parasite <ns4:italic>Schistosoma haematobium</ns4:italic>. Over 90% human cases are found in sub-Saharan Africa with 3.8 million people infected schistosomes Zambia. Reported FGS prevalence ranges from 33-75% those urinary endemic areas, suggesting potentially high burden...
Female genital schistosomiasis (FGS) has been associated with prevalent HIV-1. We estimated the incidence of HIV-1 infection in Zambian women and without FGS.Women (aged 18-31, nonpregnant, sexually active) were invited to participate this study January-August 2018 at final follow-up HPTN 071 (PopART) Population Cohort. HIV-1-negative participants enrollment (n = 492) included analysis, testing confirm incident performed (PopART). The association FGS (Schistosoma DNA detected by polymerase...
The objective of the study was to determine prevalence pediatric human immunodeficiency virus 1 (HIV-1) mucocutaneous manifestations in era highly active antiretroviral therapy (HAART). We conducted population-based, prospective, multicenter HIV-1 surveillance 276 children with perinatally acquired from 1988 2009. Centers for Disease Control and Prevention (CDC)-defined related conditions among were: category A (n = 152), B 60), C 1). Nearly half diagnoses (43.4% [66/152] 35.0% [21/60],...
Background: Female genital schistosomiasis (FGS) is a neglected and disabling gynaecological disorder that difficult to diagnose part of the wider spectrum urogenital disease caused by waterborne parasite Schistosoma haematobium. Over 90% human cases are found in sub-Saharan Africa with 3.8 million people infected schistosomes Zambia. Reported FGS prevalence ranges from 33-75% those urinary endemic areas, suggesting potentially high burden Zambia alone. The Bilharzia HIV (BILHIV) study...
Background: Otolaryngologic conditions are common among HIV-1-infected children. In this study, we provide data regarding prevalence of pediatric HIV-1 otolaryngologic manifestations in the era antiretroviral therapy (ART). Methods: We conducted population-based, prospective, multicenter surveillance 276 children with perinatally acquired from 1988 to 2009. All Center for Disease Control (CDC) mild, moderate and severe were evaluated. Results: CDC-defined, HIV-1-related were: 103, mild; 50,...
Instrumental variable (IV) analyses are a common causal inference technique used in the absence of randomized data. Combination Antiretroviral Therapy (cART) was first introduced 1996 and calendar periods have been as proxy for cART use. However, use misclassification can bias IV analyses.We aim to highlight differences effects antiretroviral therapy on clinical outcomes between applications traditional adapted analysis techniques.This study includes children with perinatal human...